-
公开(公告)号：US11214789B2
公开(公告)日：2022-01-04
申请号：US16124184
申请日：2018-09-06
发明人： Bart Lipkens , Walter M. Presz, Jr. , Brian Dutra , Jason Dionne , Goutam Ghoshal , Kedar C. Chitale
摘要： Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.
-
公开(公告)号：US10322949B2
公开(公告)日：2019-06-18
申请号：US15490878
申请日：2017-04-18
发明人： Bart Lipkens , Walter M. Presz, Jr. , Kedar Chitale , Brian McCarthy , Benjamin Ross-Johnsrud , Thomas J. Kennedy, III , Dane Mealey , Brian Dutra , David Sokolowski
IPC分类号： C02F1/36 , B06B1/06 , B01D17/04 , C02F1/40 , B01D19/00 , B01D21/28 , C12M1/42 , G10K11/28 , C12N1/02 , C12N13/00 , C12M1/00 , H01L41/09
摘要： Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
-
公开(公告)号：US20190144843A1
公开(公告)日：2019-05-16
申请号：US16124184
申请日：2018-09-06
发明人： Bart Lipkens , Walter M. Presz, JR. , Brian Dutra , Jason Dionne , Goutam Ghoshal , Kedar C. Chitale
摘要： Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.
-
公开(公告)号：US20180362918A1
公开(公告)日：2018-12-20
申请号：US16010296
申请日：2018-06-15
发明人： Bart Lipkens , Rui Tostoes , Brian Dutra , Rudolf Gilmanshin , Jason Dionne , Walter M. Presz, JR. , Benjamin Ross-Johnsrud , Goutam Ghoshal , Kedar Chitale
摘要： A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
-
公开(公告)号：US20170204360A1
公开(公告)日：2017-07-20
申请号：US15475469
申请日：2017-03-31
发明人： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
CPC分类号： C12M47/10 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M23/14 , C12M23/22 , C12M27/00 , C12M27/02 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/02 , C12M47/04 , C12P21/02
摘要： A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
-
公开(公告)号：US20170191022A1
公开(公告)日：2017-07-06
申请号：US15466289
申请日：2017-03-22
发明人： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin , John Rozembersky
CPC分类号： C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B01J19/10 , B01J19/18 , B01J2219/00094 , B06B1/0644 , C02F1/004 , C02F1/36 , C02F1/40 , C02F3/1268 , C02F11/12 , C12M23/14 , C12M23/22 , C12M27/02 , C12M29/02 , C12M29/04 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/10 , Y02W10/15
摘要： A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
-
公开(公告)号：US20170049949A1
公开(公告)日：2017-02-23
申请号：US15257515
申请日：2016-09-06
发明人： Rudolf Gilmanshin , Bart Lipkens , Brian Dutra , Daniel Kennedy
CPC分类号： A61M1/3678 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2202/0456 , B01D21/286 , B01D21/30 , B01D21/34 , B01D2221/10 , B06B1/0644
摘要： Acoustophoretic devices are disclosed. The devices include a flow chamber, an ultrasonic transducer, a reflector, an inlet, a filtrate outlet, a concentrate outlet, and optionally a lipid collection trap. The ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the flow chamber that traps and separates red blood cells and/or lipids from blood. Concentrated red blood cells can be recovered via the concentrate outlet, the lipids can be recovered via the lipid collection trap, and the remaining blood can be recovered via the filtrate outlet. Methods for separating blood components (e.g., red blood cells, lipids, platelets, white blood cells) from blood are also disclosed. The red blood cells can undergo washing with a solvent to remove undesired admixtures. Cryoprotectants can be added or removed from the blood.
摘要翻译： 公开了声学设备。 这些装置包括流动室，超声换能器，反射器，入口，滤液出口，浓缩物出口和任选的脂质收集阱。 超声波换能器和反射器在流动室中产生多维声驻波，其捕获并分离红细胞和/或血液与血液。 可以通过浓缩物出口回收浓缩的红细胞，通过脂质收集阱可以回收脂质，剩余的血液可以通过滤液出口回收。 还公开了从血液中分离血液成分（例如红细胞，脂质，血小板，白细胞）的方法。 红细胞可以用溶剂洗涤以除去不需要的混合物。 可以从血液中加入或除去冷冻保护剂。
-
公开(公告)号：US11324873B2
公开(公告)日：2022-05-10
申请号：US15257515
申请日：2016-09-06
发明人： Rudolf Gilmanshin , Bart Lipkens , Brian Dutra , Daniel Kennedy
摘要： Acoustophoretic devices are disclosed. The devices include a flow chamber, an ultrasonic transducer, a reflector, an inlet, a filtrate outlet, a concentrate outlet, and optionally a lipid collection trap. The ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the flow chamber that traps and separates red blood cells and/or lipids from blood. Concentrated red blood cells can be recovered via the concentrate outlet, the lipids can be recovered via the lipid collection trap, and the remaining blood can be recovered via the filtrate outlet. Methods for separating blood components (e.g., red blood cells, lipids, platelets, white blood cells) from blood are also disclosed. The red blood cells can undergo washing with a solvent to remove undesired admixtures. Cryoprotectants can be added or removed from the blood.
-
公开(公告)号：US11179747B2
公开(公告)日：2021-11-23
申请号：US15206244
申请日：2016-07-09
发明人： Bart Lipkens , Walter M Presz, Jr. , Kedar Chitale , Thomas J Kennedy, III , Rudolf Gilmanshin , Dane Mealey , Brian Dutra , David Sokolowski
摘要： An acoustophoretic device is disclosed. The acoustophoretic device includes an acoustic chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber emanating from a non-planar face of the piezoelectric material. A method for separating a second fluid or a particulate from a host fluid is also disclosed. The method includes flowing the mixture through an acoustophoretic device. A voltage signal is sent to drive the ultrasonic transducer to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.
-
公开(公告)号：US10201652B2
公开(公告)日：2019-02-12
申请号：US13866584
申请日：2013-04-19
发明人： Brian Dutra , Bart Lipkens , Daniel Kennedy , Michael J. Rust
摘要： A system for removing lipids from blood during cardiopulmonary bypass surgery is disclosed. The system uses an acoustophoretic separator having improved trapping force. The transducer of the acoustophoretic seperator includes a ceramic crystal. Blood flows through the separator, and lipids are trapped and removed.
-
-
-
-
-
-
-
-
-
搜索结果
43 条记录 (耗时 0.03 秒)
