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    Systems and methods for photoactivation of a biological fluid
    1.
    发明授权
    Systems and methods for photoactivation of a biological fluid 有权

    公开(公告)号：US11883543B2

    公开(公告)日：2024-01-30

    申请号：US16834012

    申请日：2020-03-30

    申请人： Fenwal, Inc.

    发明人： Lan T. Nguyen ,  Angela N. Carlson ,  Katherine N. Radwanski ,  Greg Coultas ,  Yamen Alshawaf ,  Kevin Schalte

    IPC分类号： A61L2/00 ,  A61M1/36 ,  A61L2/24

    CPC分类号： A61L2/0052 ,  A61L2/0047 ,  A61L2/24 ,  A61M1/3622 ,  A61L2202/14 ,  A61L2202/22

    摘要： Methods and systems for treating a biological fluid with light are disclosed. The methods and systems provide for determining a target light dose for the biological fluid; loading a treatment container holding the biological fluid into an irradiation chamber of an irradiation device comprising: with the treatment container being supported in the irradiation device in between a first array of light sources and first light energy sensors and a second light energy sensor. The first array of light sources is activated, and a first light intensity is measured with the first light energy sensors. A second light intensity is measured with the second light energy sensor, and the first light intensity is compared to the second light intensity to determine an attenuation factor. The attenuation factor is applied to the first light intensity to determine a time to achieve the target light dose, with the first array of multiple light sources being deactivated after the time to achieve the target light dose has elapsed.

    SYSTEMS AND METHODS FOR PERFORMING EXTRACORPOREAL PHOTOPHERESIS
    3.
    发明申请
    SYSTEMS AND METHODS FOR PERFORMING EXTRACORPOREAL PHOTOPHERESIS 有权

    公开(公告)号：US20220347368A1

    公开(公告)日：2022-11-03

    申请号：US17716579

    申请日：2022-04-08

    申请人： Fenwal, Inc.

    发明人： Lan T. Nguyen ,  Katherine N. Radwanski ,  Greg Coultas

    IPC分类号： A61M1/36 ,  A61M1/34

    摘要： Systems and methods are disclosed for performing online extracorporeal photopheresis in which the needs of a particular patient as to the fluid balance to be achieved and the time allotted to perform the procedure can be prioritized. Whole blood is removed from a patient and introduced through a processing set into a separation chamber to separate the desired cell population from the blood. The separated cell population is processed through the set which is associated with a treatment chamber where the cells are treated. Once treated, the cells are returned to the patient.

    SYSTEMS AND METHODS FOR PHOTOACTIVATION OF A BIOLOGICAL FLUID
    4.
    发明申请
    SYSTEMS AND METHODS FOR PHOTOACTIVATION OF A BIOLOGICAL FLUID 审中-公开

    公开(公告)号：US20200330628A1

    公开(公告)日：2020-10-22

    申请号：US16834012

    申请日：2020-03-30

    申请人： Fenwal, Inc.

    发明人： Lan T. Nguyen ,  Angela N. Carlson ,  Katherine N. Radwanski ,  Greg Coultas ,  Yamen Alshawaf ,  Kevin Schalte

    IPC分类号： A61L2/00 ,  A61L2/24

    摘要： Methods and systems for treating a biological fluid with light are disclosed. The methods and systems provide for determining a target light dose for the biological fluid; loading a treatment container holding the biological fluid into an irradiation chamber of an irradiation device comprising: with the treatment container being supported in the irradiation device in between a first array of light sources and first light energy sensors and a second light energy sensor. The first array of light sources is activated, and a first light intensity is measured with the first light energy sensors. A second light intensity is measured with the second light energy sensor, and the first light intensity is compared to the second light intensity to determine an attenuation factor. The attenuation factor is applied to the first light intensity to determine a time to achieve the target light dose, with the first array of multiple light sources being deactivated after the time to achieve the target light dose has elapsed.

    Systems And Methods For Therapeutic Platelet Depletion
    5.
    发明申请
    Systems And Methods For Therapeutic Platelet Depletion 审中-公开

    公开(公告)号：US20190336659A1

    公开(公告)日：2019-11-07

    申请号：US16515114

    申请日：2019-07-18

    申请人： Fenwal, Inc.

    发明人： Katherine N. Radwanski ,  Kyungyoon Min ,  Zahra R. Ali

    IPC分类号： A61M1/02 ,  A61M1/36 ,  A61M1/30 ,  B04B11/06 ,  B04B5/04 ,  B04B7/00 ,  A61M1/38

    摘要： Systems and methods are provided for depleting platelets from blood. The system includes a multi-stage blood separation chamber in which blood is separated into red blood cells and platelet-rich plasma. The platelet-rich plasma is conveyed from a first stage of the chamber to a second stage, where it is separated into platelets and platelet-poor plasma. The platelet-poor plasma is conveyed out of the chamber while the platelets are allowed to accumulate in the second stage of the chamber. When a controller of the system has determined that the maximum chamber capacity of platelets has been accumulated in the second stage of the chamber, the platelets are conveyed out of the chamber to a waste container. The cycle of separating blood into its components, accumulating platelets in the chamber, and then flushing the platelets from the chamber is repeated until a target platelet concentration of the blood is achieved.

    SYSTEMS AND METHODS FOR PLASMA COLLECTION
    8.
    发明公开
    SYSTEMS AND METHODS FOR PLASMA COLLECTION 审中-公开

    公开(公告)号：US20240023855A1

    公开(公告)日：2024-01-25

    申请号：US18371795

    申请日：2023-09-22

    申请人： FENWAL, INC.

    发明人： Amit J. Patel ,  Samantha M. Planas ,  Walter T. Watts ,  Kyungyoon Min ,  Daniel R. Boggs ,  Katherine N. Radwanski

    IPC分类号： A61B5/15

    CPC分类号： A61B5/150992 ,  A61B5/150229 ,  A61B5/150343 ,  A61B5/150251 ,  A61B2560/0487

    摘要： A plasmapheresis system and a method for operating a plasmapheresis system are provided by which a volume of plasma product (i.e., anticoagulated plasma) so that that the targeted volume of pure plasma in the plasma product is determined based on donor-specific characteristics. In particular, the targeted amount of pure plasma to be collected is based on the weight, or the weight and the height, of the donor. The targeted volume of pure plasma to be collected, TVP, may be a multiple of the donors weight. Alternatively, TVP may be a multiple of the donor's total blood volume, TBV, with the TBV of the donor being determined based on the donor's weight and height. A target volume for the plasma product to be collected, TVPP, is established, and separation of whole blood into a plasma component and a second component continues until the volume of plasma product in a collection container equals TVPP.

    Systems and methods for plasma collection
    9.
    发明授权
    Systems and methods for plasma collection 有权

    公开(公告)号：US11801001B2

    公开(公告)日：2023-10-31

    申请号：US17861437

    申请日：2022-07-11

    申请人： FENWAL, INC.

    发明人： Amit J. Patel ,  Samantha M. Planas ,  Walter T. Watts ,  Kyungyoon Min ,  Daniel R. Boggs ,  Katherine N. Radwanski

    IPC分类号： A61B5/15

    CPC分类号： A61B5/150992 ,  A61B5/150229 ,  A61B5/150251 ,  A61B5/150343 ,  A61B2560/0487

    摘要： A plasmapheresis system and a method for operating a plasmapheresis system are provided by which a volume of plasma product (i.e., anticoagulated plasma) so that that the targeted volume of pure plasma in the plasma product is determined based on donor-specific characteristics. In particular, the targeted amount of pure plasma to be collected is based on the weight, or the weight and the height, of the donor. The targeted volume of pure plasma to be collected, TVP, may be a multiple of the donor's weight. Alternatively, TVP may be a multiple of the donor's total blood volume, TBV, with the TBV of the donor being determined based on the donor's weight and height. A target volume for the plasma product to be collected, TVPP, is established, and separation of whole blood into a plasma component and a second component continues until the volume of plasma product in a collection container equals TVPP.

    Systems and methods for performing online extracorporeal photopheresis
    10.
    发明授权
    Systems and methods for performing online extracorporeal photopheresis 有权

    公开(公告)号：US11318239B2

    公开(公告)日：2022-05-03

    申请号：US16286726

    申请日：2019-02-27

    申请人： Fenwal, Inc.

    发明人： Zahra R. Ali ,  Lan T. Nguyen ,  Katherine N. Radwanski ,  Angela N. Carlson ,  Tanima J. Abedin

    IPC分类号： A61M1/36 ,  A61M1/30 ,  A61M1/34

    摘要： Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. During a mononuclear cell collection cycle, blood is removed from a source and separated into a plasma constituent, a mononuclear cell-containing layer, and red blood cells, followed by the collection of a pre-product including at least a portion of the mononuclear cell-containing layer and at least a portion of the separated red blood cells. The mononuclear cell collection cycle may be repeated, followed by the production of a single mononuclear cell product using the collected pre-product(s). The mononuclear cell product is irradiated using a fixed dose of light, such that the mononuclear cell product is produced so as to have a predetermined volume and a predetermined hematocrit, regardless of the number of pre-products used to produce the mononuclear cell product. Following irradiation, at least a portion of the irradiated mononuclear cell product is returned to the source.