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公开(公告)号：US20220404602A1
公开(公告)日：2022-12-22
申请号：US17619902
申请日：2020-12-18
申请人： FEI DEUTSCHLAND GMBH
摘要： An imaging system configured for automatic application and/or removal of immersion media can include (i) a sample stage, (ii) an imaging assembly disposed on a first side of the sample stage and having an immersion objective configured to selectively align with an optical axis of the imaging system, and (iii) an applicator positioned to selectively interact with a lens surface of the immersion objective to deposit or remove immersion media.
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公开(公告)号：US20220399197A1
公开(公告)日：2022-12-15
申请号：US17755179
申请日：2020-11-10
发明人： Alexander Makarov , Michael WARD , Rainer DAUM
摘要： Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device (110) includes an optical assembly (112), a sample stage (114), and a receiver (116). The optical assembly (112) is disposed in an inverted position below the sample stage (114) and the receiver (116) is positioned above the sample stage (112). The optical assembly enables imaging of a sample disposed on the sample stage (114). The optical assembly (112) also enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume (20) toward the receiver (116).
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公开(公告)号：US20230003964A1
公开(公告)日：2023-01-05
申请号：US17843797
申请日：2022-06-17
申请人： FEI DEUTSCHLAND GMBH
发明人： Rainer DAUM , Xaver VOEGELE , Gerrit PAHL
摘要： A system for selectively adjusting an objective lens correction collar includes a gear ring sized and shaped to fit about a correction collar of an objective lens. The system also includes an adjustment mechanism that has a motor operably connected to a complementary gear configured to selectively engage and cause movement of the gear ring, thereby adjusting the correction collar.
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公开(公告)号：US20240035978A1
公开(公告)日：2024-02-01
申请号：US18356979
申请日：2023-07-21
申请人： FEI DEUTSCHLAND GMBH
发明人： Rainer DAUM , Xaver VOEGELE
CPC分类号： G01N21/6458 , G02B21/16 , G02B21/0032 , G02B21/0036 , G02B21/0076 , G02B21/24 , G01N2201/08 , G01N2201/06113 , G01N2201/105
摘要： Disclosed are confocal microscope systems capable of spectral multiplexing. The systems beneficially provide multiple excitation spots on a sample plane simultaneously, and each spot can provide a different wavelength of excitation light. Scanning the excitation spots across a sample can therefore provide multispectral fluorescence imaging at a faster rate than through the sequential process of conventional laser scanning confocal microscopes. A method of generating a distribution from multiplexed spectral fluorescence data is also disclosed.
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公开(公告)号：US20230408838A1
公开(公告)日：2023-12-21
申请号：US18032540
申请日：2021-10-19
申请人： FEI DEUTSCHLAND GMBH
发明人： Rainer DAUM , Meike PEDERSEN
摘要： A perfusion system for reducing or eliminating sample drift during microscopy imaging includes a sample chamber that has an inlet opening associated therewith. The perfusion system also includes a reservoir, which is in fluid communication with the inlet opening and positioned above the inlet opening in a direction opposite the force of gravity. The perfusion system includes an outlet opening associated with the sample chamber. Furthermore, the perfusion system includes a wick. A first portion of the wick forms a fluid-tight connection with the outlet opening. A second portion of the wick is disposed within a waste tank. A capillary tension of the wick contributes to a laminar flow of fluid across an optical detection area of the sample chamber.
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6.发明公开公开(公告)号：US20230384225A1
公开(公告)日：2023-11-30
申请号：US18032331
申请日：2021-10-20
申请人： FEI DEUTSCHLAND GMBH
发明人： Rainer DAUM , Bruce PIRGER
CPC分类号： G01N21/6458 , G01N21/6408 , G01N21/65
摘要： An imaging system having one or more single-photon detectors is configured to enable rapid switching between different operational modes. The imaging system includes a reprogrammable controller communicatively coupled to one or more single-photon detectors and to a host computer device via a high-speed data link. In operation, the one or more single-photon detectors are operated according to a first operational mode. A reprogrammable logic device of the controller is then reconfigured to operate the one or more single-photon detectors in a second operational mode without requiring changes to the overall hardware configuration/setup of the imaging system.
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公开(公告)号：US20230011590A1
公开(公告)日：2023-01-12
申请号：US17751506
申请日：2022-05-23
发明人： Alexander MAKAROV , Michael WARD , Rainer DAUM
摘要： Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device includes an optical assembly, a sample stage, and a receiver. The optical assembly enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume toward the receiver. A laser focus detection unit including at least one reference laser and photodetector generates at least one real-time detection signal indicative of one or more characteristics of the sample during ablation and/or of a distance from the objective to the sample stage or a surface of the sample. A controller coupled with the laser focus detection unit dynamically controls in real-time one or more parameters of the ablation laser and/or a position of the objective and/or a position of the receiver relative to the sample to improve MS imaging quality.
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