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    ADVANCED PULMONARY MODELS
    2.
    发明公开
    ADVANCED PULMONARY MODELS 审中-公开

    公开(公告)号：US20230287355A1

    公开(公告)日：2023-09-14

    申请号：US18083916

    申请日：2022-12-19

    申请人： EMULATE, INC.

    发明人： Remi Villenave ,  Carolina Lucchesi ,  Justin Nguyen ,  Catherine Karalis ,  Geraldine Hamilton ,  Buket Baddal ,  Michael Salmon

    IPC分类号： C12N5/071 ,  B01L3/00 ,  C12N1/20

    CPC分类号： C12N5/0688 ,  B01L3/502769 ,  C12N1/20 ,  C12N2502/00

    摘要： The present invention relates to microfluidic fluidic systems and methods for the in vitro modeling diseases of the lung and small airway. In one embodiment, the invention relates to a system for testing responses of a microfluidic Small Airway-on-Chip infected with one or more infectious agents (e.g. respiratory viruses) as a model of respiratory disease exacerbation (e.g. asthma exacerbation). In one embodiment, this disease model on a microfluidic chip allows for a) the testing of anti-inflammatory and/or anti-viral compounds introduced into the system, as well as b) the monitoring of the participation, recruitment and/or movement of immune cells, including the transmigration of cells. In particular, this system provides, in one embodiment, an in-vitro platform for modeling severe asthma as “Severe Asthma-on-Chip.” In some embodiments, this invention provides a model of viral-induced asthma in humans for use in identifying potentially effective treatments.

    In vitro gastrointestinal model comprising lamina propria-derived cells
    4.
    发明授权
    In vitro gastrointestinal model comprising lamina propria-derived cells 有权

    公开(公告)号：US11001795B2

    公开(公告)日：2021-05-11

    申请号：US15819966

    申请日：2017-11-21

    申请人： EMULATE, Inc.

    发明人： S. Jordan Kerns ,  Jenifer Obrigewitch ,  Michael Salmon ,  Magdalena Kasendra ,  Benjamin Richards Umiker

    IPC分类号： C12M3/06 ,  G01N33/50 ,  B01L3/00 ,  C12N5/077 ,  C12N5/071 ,  C07K16/28 ,  C12M1/12 ,  C12N5/0783

    摘要： An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic gut-on-chips allow identification of cells and cellular derived factors driving disease states and drug testing for reducing inflammation.

    In vitro gastrointestinal model comprising lamina propria-derived cells
    5.
    发明授权
    In vitro gastrointestinal model comprising lamina propria-derived cells 有权

    公开(公告)号：US11230688B2

    公开(公告)日：2022-01-25

    申请号：US15820011

    申请日：2017-11-21

    申请人： EMULATE, Inc.

    发明人： S. Jordan Kerns ,  Jenifer Obrigewitch ,  Michael Salmon ,  Benjamin Richards Umiker

    IPC分类号： C12M3/06 ,  G01N33/50 ,  B01L3/00 ,  C12N5/077 ,  C12N5/071 ,  C07K16/28 ,  C12M1/12 ,  C12N5/0783

    摘要： An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic gut-on-chips allow identification of cells and cellular derived factors driving disease states and drug testing for reducing inflammation.

    Advanced pulmonary models
    8.
    发明授权
    Advanced pulmonary models 有权

    公开(公告)号：US11542476B2

    公开(公告)日：2023-01-03

    申请号：US16692383

    申请日：2019-11-22

    申请人： EMULATE, INC.

    发明人： Remi Villenave ,  Carolina Lucchesi ,  Justin Nguyen ,  Catherine Karalis ,  Geraldine Hamilton ,  Buket Baddal ,  Michael Salmon

    IPC分类号： C12N5/071 ,  B01L3/00 ,  C12N1/20

    摘要： The present invention relates to microfluidic fluidic systems and methods for the in vitro modeling diseases of the lung and small airway. In one embodiment, the invention relates to a system for testing responses of a microfluidic Small Airway-on-Chip infected with one or more infectious agents (e.g. respiratory viruses) as a model of respiratory disease exacerbation (e.g. asthma exacerbation). In one embodiment, this disease model on a microfluidic chip allows for a) the testing of anti-inflammatory and/or anti-viral compounds introduced into the system, as well as b) the monitoring of the participation, recruitment and/or movement of immune cells, including the transmigration of cells. In particular, this system provides, in one embodiment, an in-vitro platform for modeling severe asthma as “Severe Asthma-on-Chip.” In some embodiments, this invention provides a model of viral-induced asthma in humans for use in identifying potentially effective treatments.