公开(公告)号：US20240309331A1

公开(公告)日：2024-09-19

申请号：US18591819

申请日：2024-02-29

申请人： Emulate, Inc.

发明人： S. Jordan Kerns ,  Catherine Karalis ,  Janna Nawroth ,  Remi Villenave ,  Jenifer Obrigewitch ,  Doris Roth ,  Michael Salmon ,  Athanasia Apostolou ,  David Conegliano

IPC分类号： C12N5/071 ,  C12M1/42 ,  C12M3/06 ,  C12N1/20 ,  C12Q1/04

CPC分类号： C12N5/0679 ,  C12M23/16 ,  C12M35/04 ,  C12M35/08 ,  C12N1/20 ,  C12N5/0688 ,  C12Q1/04 ,  C12N2500/02 ,  C12N2502/70 ,  C12N2506/23 ,  C12N2537/00

摘要： The present invention relates to a combination of microbes, cell culture systems and microfluidic fluidic systems for use in providing a human Intestine On-Chip with optimal intestinal motility. More specifically, in some embodiments, a microfluidic chip containing intestinal epithelial cells co-cultured with intestinal endothelial cells in the presence of bacteria, such as probiotic bacteria, may find use in providing an Intestine-On-Chip for testing intestinal motility function. In some embodiments, an Intestine On-Chip may be used for identifying (testing) therapeutic compounds continuing probiotic microbes or compounds for inducing intestinal motility for use in treating gastrointestinal disorders or diseases related to intestinal function.

公开(公告)号：US20210115406A1

公开(公告)日：2021-04-22

申请号：US17088828

申请日：2020-11-04

申请人： EMULATE, INC.

发明人： S. Jordan Kerns ,  Catherine Karalis ,  Janna Nawroth ,  Remi Villenave ,  Jenifer Obrigewitch ,  Doris Roth ,  Michael Salmon ,  Athanasia Apostolou ,  David Conegliano

IPC分类号： C12N5/071 ,  C12M3/06 ,  C12M1/42 ,  C12N1/20 ,  C12Q1/04

摘要： The present invention relates to a combination of microbes, cell culture systems and microfluidic fluidic systems for use in providing a human Intestine On-Chip with optimal intestinal motility. More specifically, in some embodiments, a microfluidic chip containing intestinal epithelial cells co-cultured with intestinal endothelial cells in the presence of bacteria, such as probiotic bacteria, may find use in providing an Intestine-On-Chip for testing intestinal motility function. In some embodiments, an Intestine On-Chip may be used for identifying (testing) therapeutic compounds continuing probiotic microbes or compounds for inducing intestinal motility for use in treating gastrointestinal disorders or diseases related to intestinal function.