公开(公告)号：US09629963B2

公开(公告)日：2017-04-25

申请号：US13664273

申请日：2012-10-30

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Hon Wah Chin ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene

IPC分类号： A61M31/00 ,  A61M5/42 ,  A61B90/13 ,  A61B90/11 ,  A61F7/00 ,  A61B90/00

CPC分类号： A61M5/427 ,  A61B90/11 ,  A61B90/13 ,  A61B2090/364 ,  A61F7/00 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2205/587 ,  G16H10/60 ,  Y02A90/26

摘要： System and methods are described herein for generating an injection guide, which include receiving one or more digital images of a body region of an individual, the body region including one or more physical registration landmarks, generating at least one digital representation of the body region using the one or more digital images, the at least one digital representation including one or more digital registration landmarks corresponding to the one or more physical registration landmarks on the body region, adding one or more digitally registered injection sites to the at least one digital representation of the body region in an injection-treatment pattern, the one or more digitally registered injection sites registered relative to the one or more digital registration landmarks, and generating one or more output signals having information for controlling one or more controllable light-emitting elements to illuminate a location on a surface of the body region of the individual corresponding in location to at least one of the one or more digitally registered injection sites.

公开(公告)号：US20160245990A1

公开(公告)日：2016-08-25

申请号：US14627835

申请日：2015-02-20

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Paul Santiago ,  Todd J. Stewart ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： G02B6/02 ,  A61N5/06 ,  G02B6/036

CPC分类号： G02B6/02033 ,  A61B90/30 ,  A61B2017/00004 ,  A61B2017/00061 ,  A61B2017/00526 ,  A61B2017/00893 ,  A61B2018/2222 ,  A61B2018/2244 ,  A61B2090/306 ,  A61B2562/223 ,  A61F13/00051 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0662

摘要： A device and methods of use thereof are disclosed herein for a biodegradable optical fiber and a method of producing a device including a biodegradable optical fiber. A device is disclosed that includes: a biodegradable optical fiber including; a biodegradable optically functional inner fiber including an optically-transmitting cladding in contact with and surrounding an optically-transmitting core, wherein the inner fiber is biodegradable on a first time scale; and an outer layer in contact with and surrounding the optically-transmitting cladding, wherein the outer layer is biodegradable on a controllably-defined delayed time scale, and the controllably-defined delayed time scale is of greater duration than the first time scale.

摘要翻译： 本文公开了一种可生物降解的光纤的装置及其使用方法，以及包括生物降解性光纤的装置的制造方法。 公开了一种装置，包括：生物可降解光纤，包括： 可生物降解的光学功能内部纤维，其包括与光学透射芯接触并围绕光学透射芯的光学透射包层，其中所述内纤维以第一时间刻度可生物降解; 以及与所述光学透射包层接触并围绕所述光学透射包层的外层，其中所述外层在可控定义的延迟时间尺度上是可生物降解的，并且所述可控定义的延迟时间尺度具有比所述第一时间尺度更长的持续时间。

公开(公告)号：US09333071B2

公开(公告)日：2016-05-10

申请号：US14301607

申请日：2014-06-11

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene

IPC分类号： A61F2/12 ,  G01N33/574 ,  G01N33/52 ,  A61B5/00 ,  A61B5/145 ,  A61B5/07 ,  A61B5/1473

CPC分类号： A61F2/12 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/14735 ,  A61B5/4312 ,  A61B5/686 ,  A61B5/6867 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0443 ,  A61B2562/028 ,  A61B2562/06 ,  A61B2562/162 ,  A61B2562/168 ,  G01N33/528 ,  G01N33/57415

摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; a plurality of projections extending from an external surface of the shell, the projections forming a plurality of compartments adjacent to the external surface of the shell; at least one fluid-permeable cover attached to the projections, the cover completely enveloping the shell and the plurality of projections; a plurality of sensor modules attached to the shell, each of the sensor modules oriented to detect one or more analytes in a fluid within one of the plurality of compartments, wherein each of the plurality of sensor modules includes a unique identifier; and at least one power source operably attached to the plurality of sensor modules.

摘要翻译： 本文描述了包括传感器模块和相关方法的乳房植入物。 乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 从所述壳体的外表面延伸的多个突起，所述突起形成与所述壳体的外表面相邻的多个隔室; 至少一个液体可渗透的盖附接到突起，所述盖完全包围壳体和多个突起; 多个传感器模块，其附接到所述壳体，所述传感器模块中的每一个被定向以检测所述多个隔室中的一个内的流体中的一种或多种分析物，其中所述多个传感器模块中的每一个包括唯一标识符; 以及可操作地附接到所述多个传感器模块的至少一个电源。

公开(公告)号：US20140296663A1

公开(公告)日：2014-10-02

申请号：US14301077

申请日：2014-06-10

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene

IPC分类号： A61B5/00 ,  A61F2/12

CPC分类号： A61B5/686 ,  A61B5/076 ,  A61B5/4312 ,  A61B5/4848 ,  A61B5/4851 ,  A61F2/12

摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; at least one fluid-permeable cover, the cover completely enveloping the shell; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the sensor modules oriented to detect one or more analytes in a fluid between the shell and the cover, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.

摘要翻译： 本文描述了包括传感器模块和相关方法的乳房植入物。 乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 至少一个流体可透过的盖，所述盖完全包围所述壳; 以及多个传感器模块，其附接到壳体并且彼此间隔一定距离，每个传感器模块被定向成检测壳体和盖子之间的流体中的一种或多种分析物，其中多个传感器模块中的每一个包括 唯一的标识符并被配置为利用从外部源发送的能量。

公开(公告)号：US08828081B2

公开(公告)日：2014-09-09

申请号：US13628442

申请日：2012-09-27

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Clarence T. Tegreene

IPC分类号： A61F2/28

CPC分类号： A61F2/30 ,  A61F2/30742 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2002/30079 ,  A61F2002/30087 ,  A61F2002/30558 ,  A61F2002/30673 ,  A61F2002/30682 ,  A61F2002/30683 ,  A61F2002/3082 ,  A61F2002/3092 ,  A61F2002/3429 ,  A61F2002/3631 ,  A61F2002/482

摘要： Artificial joint prosthetic components including synovial fluid deflection structures are described. Embodiments of artificial joint prosthesis include those with: a bone-facing surface of a artificial joint prosthesis, the bone-facing surface configured to face a bone-prosthesis interface in vivo; a non-contact surface of the artificial joint prosthesis; and at least one fluid deflection structure positioned on the non-contact surface, the fluid deflection structure positioned to deflect synovial fluid away from the bone-prosthesis interface in vivo.

摘要翻译： 描述了包括滑液偏转结构在内的人造关节假体部件。 人造关节假体的实施例包括具有：人造关节假体的面向骨的表面的面向骨体的表面，所述骨对面表面构造成在体内面向骨假体界面; 人造关节假体的非接触表面; 以及定位在所述非接触表面上的至少一个流体偏转结构，所述流体偏转结构被定位成使滑液在体内远离骨假体界面偏转。

公开(公告)号：US10143809B2

公开(公告)日：2018-12-04

申请号：US15376885

申请日：2016-12-13

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Hon Wah Chin ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene

IPC分类号： A61M31/00 ,  A61M5/42 ,  A61B90/13 ,  A61B90/11 ,  A61F7/00 ,  A61B90/00 ,  G16H10/60

摘要： Systems and methods are described herein for guided injection, which include: one or more controllable light-emitting elements configured to emit non-destructive light and a computing device operably connected to the one or more controllable light-emitting elements configured to emit non-destructive light, the computing device including a processor operable to receive at least one digital representation of a body region of an individual, the body region of the individual including one or more physical registration landmarks, the at least one digital representation including one or more digitally registered injection sites and one or more digital registration landmarks corresponding to the one or more physical registration landmarks on the body region; and control the one or more controllable light-emitting elements to illuminate a location of a surface of the body region of the individual corresponding in location to at least one of the one or more digitally registered injection sites.

公开(公告)号：US20170259013A1

公开(公告)日：2017-09-14

申请号：US15474016

申请日：2017-03-30

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Hon Wah Chin ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene

IPC分类号： A61M5/42 ,  A61B90/13 ,  A61B90/11

CPC分类号： A61M5/427 ,  A61B90/11 ,  A61B90/13 ,  A61B90/92 ,  A61B90/94 ,  A61B2090/364 ,  A61F7/00 ,  A61F7/02 ,  A61F7/10 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17

摘要： System and methods are described herein for generating an injection guide, which include receiving one or more digital images of a body region of an individual, the body region including one or more physical registration landmarks, generating at least one digital representation of the body region using the one or more digital images, the at least one digital representation including one or more digital registration landmarks corresponding to the one or more physical registration landmarks on the body region, adding one or more digitally registered injection sites to the at least one digital representation of the body region in an injection-treatment pattern, the one or more digitally registered injection sites registered relative to the one or more digital registration landmarks, and generating one or more output signals having information for controlling one or more controllable light-emitting elements to illuminate a location on a surface of the body region of the individual corresponding in location to at least one of the one or more digitally registered injection sites.

公开(公告)号：US20150327989A1

公开(公告)日：2015-11-19

申请号：US14809389

申请日：2015-07-27

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene

IPC分类号： A61F2/12

CPC分类号： A61F2/12 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14546 ,  A61B5/4312 ,  A61B5/686 ,  A61B5/6867 ,  A61B2560/0219 ,  A61F2250/0085 ,  A61F2250/0096

摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the plurality of sensor modules oriented to detect one or more analytes in a fluid adjacent to the shell, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.

摘要翻译： 本文描述了包括传感器模块和相关方法的乳房植入物。 乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 以及多个传感器模块，其附接到壳体并且彼此间隔一定距离，多个传感器模块中的每一个被定向成检测与壳体相邻的流体中的一种或多种分析物，其中多个传感器模块中的每一个包括 唯一的标识符并被配置为利用从外部源发送的能量。

公开(公告)号：US20140303660A1

公开(公告)日：2014-10-09

申请号：US13857038

申请日：2013-04-04

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Gregory J. Della Rocca ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Clarence T. Tegreene

IPC分类号： A61B17/32

CPC分类号： A61B17/32 ,  A61B17/32002 ,  A61B17/3211 ,  A61B34/75 ,  A61B90/90

摘要： Described embodiments include a handheld or hand operated surgical instrument. The instrument includes an elongated member having a longitudinal axis and a handle portion. The instrument includes a working tip coupled to the elongated member. The instrument includes a sensor configured to detect a user-imparted hand tremble motion. The instrument includes a flexible beam element of the elongated member located in-between the handle portion and the working tip, and configured to reversibly bend, extend, or rotate with respect to the longitudinal axis. The instrument includes an actuator physically coupled to the flexible beam element and configured to reversibly bend, extend, or rotate the flexible beam element with respect to the longitudinal axis. The instrument includes a controller configured to stabilize the working tip by activating the actuator in a manner responsive to the detected user-imparted hand tremble motion in at least one degree of freedom.

摘要翻译： 所描述的实施例包括手持或手动手术器械。 仪器包括具有纵向轴线和手柄部分的细长构件。 仪器包括联接到细长构件的工作尖端。 该仪器包括被配置为检测用户传递的手颤动的传感器。 仪器包括位于手柄部分和工作尖端之间的细长构件的柔性梁元件，并且构造成相对于纵向轴线可逆地弯曲，延伸或旋转。 仪器包括物理地耦合到柔性梁元件并被配置为相对于纵向轴线可挠地弯曲，延伸或旋转柔性梁元件的致动器。 该仪器包括控制器，该控制器被配置为通过以至少一个自由度的方式响应于检测到的由用户传递的手颤动来激活致动器来稳定工作尖端。

公开(公告)号：US20140296978A1

公开(公告)日：2014-10-02

申请号：US14301607

申请日：2014-06-11

申请人： Elwha LLC

发明人： Edward S. Boyden ,  Gregory J. Della Rocca ,  Daniel Hawkins ,  Roderick A. Hyde ,  Robert Langer ,  Eric C. Leuthardt ,  Terence Myckatyn ,  Parag Jitendra Parikh ,  Dennis J. Rivet ,  Joshua S. Shimony ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene

IPC分类号： A61F2/12 ,  A61B5/00

CPC分类号： A61F2/12 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/14735 ,  A61B5/4312 ,  A61B5/686 ,  A61B5/6867 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0443 ,  A61B2562/028 ,  A61B2562/06 ,  A61B2562/162 ,  A61B2562/168 ,  G01N33/528 ,  G01N33/57415

摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; a plurality of projections extending from an external surface of the shell, the projections forming a plurality of compartments adjacent to the external surface of the shell; at least one fluid-permeable cover attached to the projections, the cover completely enveloping the shell and the plurality of projections; a plurality of sensor modules attached to the shell, each of the sensor modules oriented to detect one or more analytes in a fluid within one of the plurality of compartments, wherein each of the plurality of sensor modules includes a unique identifier; and at least one power source operably attached to the plurality of sensor modules.

摘要翻译： 本文描述了包括传感器模块和相关方法的乳房植入物。 乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 从所述壳体的外表面延伸的多个突起，所述突起形成与所述壳体的外表面相邻的多个隔室; 至少一个液体可渗透的盖附接到突起，所述盖完全包围壳体和多个突起; 多个传感器模块，其附接到所述壳体，所述传感器模块中的每一个被定向以检测所述多个隔室中的一个内的流体中的一种或多种分析物，其中所述多个传感器模块中的每一个包括唯一标识符; 以及可操作地附接到所述多个传感器模块的至少一个电源。