公开(公告)号：US07723496B2

公开(公告)日：2010-05-25

申请号：US10525105

申请日：2003-08-20

Applicant: Takafumi Ishii ,  Koji Yamamoto ,  Eiji Sunahara ,  Shuji Sato

Inventor： Takafumi Ishii ,  Koji Yamamoto ,  Eiji Sunahara ,  Shuji Sato

IPC: C07H21/04 ,  C12N15/00 ,  C12P15/00

CPC classification number: A61K45/06 ,  A61K38/1709 ,  A61K48/00 ,  C07K14/47 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/574 ,  A61K2300/00

Abstract: A compound inhibiting the activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 10, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 25 or SEQ ID NO: 27, or a salt thereof; a compound inhibiting the expression of a gene of the protein; an antisense polynucleotide containing the entire or part of a base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding the protein or its partial peptide; an antibody to the protein or its partial peptide, etc. are useful as prophylactic/therapeutic agents for cancer, etc., apoptosis promoters for cancer cells, and the like.

Abstract translation: 抑制蛋白质活性的化合物，其包含与SEQ ID NO：1，SEQ ID NO：4，SEQ ID NO：7，SEQ ID NO：10，SEQ ID NO：10所示的氨基酸序列相同或基本相同的氨基酸序列 SEQ ID NO：17，SEQ ID NO：20，SEQ ID NO：22，SEQ ID NO：25或SEQ ID NO：27，或其盐; 抑制蛋白质基因表达的化合物; 含有与编码该蛋白质或其部分肽的多核苷酸的碱基序列互补或基本上互补的全部或部分碱基序列的反义多核苷酸; 对蛋白质或其部分肽的抗体等可用作癌症等的预防/治疗剂，癌细胞的凋亡启动子等。

公开(公告)号：US20060134117A1

公开(公告)日：2006-06-22

申请号：US10525105

申请日：2003-08-20

Applicant: Takafumi Ishii ,  Koji Yamamoto ,  Eiji Sunahara ,  Shuji Sato

Inventor： Takafumi Ishii ,  Koji Yamamoto ,  Eiji Sunahara ,  Shuji Sato

IPC: C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30

CPC classification number: A61K45/06 ,  A61K38/1709 ,  A61K48/00 ,  C07K14/47 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/574 ,  A61K2300/00

Abstract: A compound inhibiting the activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 10, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 25 or SEQ ID NO: 27, or a salt thereof; a compound inhibiting the expression of a gene of the protein; an antisense polynucleotide containing the entire or part of a base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding the protein or its partial peptide; an antibody to the protein or its partial peptide, etc. are useful as prophylactic/therapeutic agents for cancer, etc., apoptosis promoters for cancer cells, and the like.

Abstract translation: 抑制蛋白质活性的化合物，其包含与SEQ ID NO：1，SEQ ID NO：4，SEQ ID NO：7，SEQ ID NO：10，SEQ ID NO：10所示的氨基酸序列相同或基本相同的氨基酸序列 SEQ ID NO：17，SEQ ID NO：20，SEQ ID NO：22，SEQ ID NO：25或SEQ ID NO：27，或其盐; 抑制蛋白质基因表达的化合物; 含有与编码该蛋白质或其部分肽的多核苷酸的碱基序列互补或基本上互补的全部或部分碱基序列的反义多核苷酸; 对蛋白质或其部分肽的抗体等可用作癌症等的预防/治疗剂，癌细胞的凋亡启动子等。

公开(公告)号：US20100008926A1

公开(公告)日：2010-01-14

申请号：US12559938

申请日：2009-09-15

Applicant: Eiji Sunahara ,  Takafumi Ishii ,  Koji Yamamoto ,  Shuji Sato

Inventor： Eiji Sunahara ,  Takafumi Ishii ,  Koji Yamamoto ,  Shuji Sato

IPC: A61K39/395 ,  C07K16/18 ,  C12N15/12 ,  A61K31/713 ,  G01N33/566 ,  A61P35/00 ,  C12Q1/68

CPC classification number: C07K14/47

Abstract: Compounds that inhibit the expression of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 7 or SEQ ID NO: 10 or the expression of a gene for the protein, the antisense polynucleotide comprising the entire or part of a base sequence complementary or substantially complementary to DNA encoding the protein or its partial peptide, the antibody to the protein or its partial peptide, etc. are useful as prophylactic/therapeutic agents for cancer, etc., apoptosis promoters, etc.

Abstract translation: 抑制包含与SEQ ID NO：1，SEQ ID NO：4，SEQ ID NO：7或SEQ ID NO：10所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的表达的化合物或 表达蛋白质的基因，包含与编码蛋白质或其部分肽的DNA互补或基本上互补的碱基序列的全部或部分的反义多核苷酸，对蛋白质或其部分肽的抗体等可用作预防性 癌症治疗剂等，细胞凋亡启动子等

公开(公告)号：US20060110393A1

公开(公告)日：2006-05-25

申请号：US10540394

申请日：2003-12-25

Applicant: Eiji Sunahara ,  Takafumi Ishi ,  Koji Yamamoto ,  Shuji Sato

Inventor： Eiji Sunahara ,  Takafumi Ishi ,  Koji Yamamoto ,  Shuji Sato

IPC: A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30

CPC classification number: C07K14/47

Abstract: Compounds that inhibit the expression of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 7 or SEQ ID NO: 10 or the expression of a gene for the protein, the antisense polynucleotide comprising the entire or part of a base sequence complementary or substantially complementary to DNA encoding the protein or its partial peptide, the antibody to the protein or its partial peptide, etc. are useful as prophylactic/therapeutic agents for cancer, etc., apoptosis promoters, etc.

Abstract translation: 抑制包含与SEQ ID NO：1，SEQ ID NO：4，SEQ ID NO：7或SEQ ID NO：10所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的表达的化合物或 表达蛋白质的基因，包含与编码蛋白质或其部分肽的DNA互补或基本上互补的碱基序列的全部或部分的反义多核苷酸，对蛋白质或其部分肽的抗体等可用作预防性 癌症治疗剂等，细胞凋亡启动子等

公开(公告)号：US09110458B2

公开(公告)日：2015-08-18

申请号：US13349783

申请日：2012-01-13

Applicant: Akira Kimura ,  Koji Yamamoto ,  Katsuhiko Ono ,  Kimiyuki Nishimura ,  Kenichiro Ueno ,  Keiichi Nakamachi

Inventor： Akira Kimura ,  Koji Yamamoto ,  Katsuhiko Ono ,  Kimiyuki Nishimura ,  Kenichiro Ueno ,  Keiichi Nakamachi

IPC: G05B19/19 ,  G05D3/10 ,  G05B19/404

CPC classification number: G05B19/404 ,  G05B2219/41056

Abstract: A positioning control apparatus has a moving body, a feed device having a guide mechanism for guiding the moving body in the direction of its feed axis and a drive mechanism for moving the moving body, a structural body supporting the feed device and a controller for controlling a moving position of the moving body with respect to a reference position on a machine tool by controlling the operation of the drive mechanism, and further has a calculating section calculating displacement of the feed device in the feed-axis direction with respect to the reference position caused by displacement of the structural body and a compensating section receiving the displacement data measured by the calculating section and adding modification data for eliminating the displacement to a control signal in the controller.

Abstract translation: 定位控制装置具有移动体，具有引导机构的进给装置，该引导机构用于沿着其进给轴线的方向引导移动体，以及用于使移动体移动的驱动机构，支撑进给装置的结构体和控制器 通过控制所述驱动机构的动作，使所述移动体相对于机床上的基准位置的移动位置，还具有计算部，计算所述进给装置相对于所述基准位置的进给轴方向的位移 由结构体的位移引起的补偿部分和接收由计算部分测量的位移数据的补偿部分，并将用于消除位移的修改数据添加到控制器中的控制信号。

公开(公告)号：US09094848B2

公开(公告)日：2015-07-28

申请号：US13816786

申请日：2010-08-23

Applicant: Seigo Nakao ,  Koji Yamamoto

Inventor： Seigo Nakao ,  Koji Yamamoto

IPC: H04M3/00 ,  H04W24/02 ,  H04W72/04 ,  H04W72/08 ,  H04W52/24 ,  H04W16/32 ,  H04W52/14

CPC classification number: H04W24/02 ,  H04W16/32 ,  H04W52/143 ,  H04W52/244 ,  H04W72/0426 ,  H04W72/082

Abstract: A base station apparatus, when performing the transmission controls of pico base stations, can perform an appropriate transmission control for each pico base station, while suppressing the increase of the amount of feedback information from a macro terminal to a macro base station and also suppressing the increase of the amount of transmission control information from the macro base station to the pico base station. In this apparatus, a transmission control unit (102) updates, on the basis of the control information, the priority level of each of a plurality of different correspondences in which the respective ones of transmission control guidelines are associated with the respective ones of a plurality of control information history patterns, and controls the transmissions on the basis of the control guidelines determined from the control information histories and the correspondences each having a respective higher priority level.

Abstract translation: 基站装置在执行微微基站的发送控制时，可以在抑制从宏终端到宏基站的反馈信息量的增加的同时，抑制各个微基站的发送控制， 传输控制信息量从宏基站增加到微微基站。 在该装置中，发送控制部（102）基于控制信息，更新各个发送控制指示与多个不同对应关系中的各个对应关系的优先级， 并且基于从控制信息历史确定的控制指南和每个具有相应较高优先级的对应来控制传输。

公开(公告)号：US08822229B2

公开(公告)日：2014-09-02

申请号：US13142262

申请日：2009-12-24

Applicant: Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

Inventor： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

IPC: G01N33/564

CPC classification number: G01N33/53 ,  G01N2400/40 ,  G01N2800/102

Abstract: The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50KS-I/KS-II of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.

Abstract translation: 本发明提供了一种免疫测定硫酸角质素水平的方法，该方法包括使硫酸角质素硫酸单克隆抗体与生物样品接触，硫酸角质素-I与硫酸角质素之间呈现相对反应特异性的硫酸角质素单体抗体 -II由IC50KS-I / KS-II表示，为0.4〜5，从而提供信号; 并从信号中检测生物样品中所含的硫酸角质素。 在该方法的基础上，本发明还提供了关于联合疾病的检测方法和评估对于关节疾病及其候选物质的补救效果的方法。 通过这些方法，可以测定样品中所含的极少量硫酸角质素。 特别地，这些方法可以高灵敏度和高特异性地确定通过常规技术难以确定的总硫酸角质素，包括硫酸角质素-I。 该方法还能够检测关节疾病并评估对于关节疾病或候选物质的补救的效果。

公开(公告)号：US08634752B2

公开(公告)日：2014-01-21

申请号：US12910410

申请日：2010-10-22

Applicant: Koji Yamamoto ,  Hiroshi Funabiki ,  Masanori Murakami ,  Jinju Okuno

Inventor： Koji Yamamoto ,  Hiroshi Funabiki ,  Masanori Murakami ,  Jinju Okuno

IPC: G03G15/20

CPC classification number: G03G15/2028

Abstract: A fixing device fixing a toner image on a recording material includes a first blowing section that blows air against a leading edge of the recording material that has passed through a nip portion formed by a heated fixing member and a pressing member kept in pressure contact with the fixing member, and a second blowing section that blows air against the recording material that has passed through the nip portion, wherein an air speed of air blown out from a first blowing outlet is higher than that of air blown out from a second blowing outlet, wherein an air flow amount from the first blowing outlet is less than that from the second blowing outlet, and wherein the first and second blowing outlets are arranged at a same positional height next to one another along a rotational axis of the fixing roller.

Abstract translation: 将调色剂图像固定在记录材料上的定影装置包括：第一吹风部，其将空气吹向已经通过由加热的固定部件形成的辊隙部的记录材料的前端，以及与该保持压力接触的压紧部件 以及第二吹送部，其将空气吹过已经通过所述夹持部的记录材料，其中从第一吹出口吹出的空气的空气速度高于从第二吹出口吹出的空气的空气速度， 其中来自所述第一吹出口的空气流量小于来自所述第二吹出口的空气流量，并且其中所述第一吹出口和所述第二吹出口沿着所述定影辊的旋转轴线彼此相邻布置在相同的位置高度处。

公开(公告)号：US08630532B2

公开(公告)日：2014-01-14

申请号：US12382827

申请日：2009-03-24

Applicant: Shunsuke Takayama ,  Koji Yamamoto ,  Hisashi Aoki

Inventor： Shunsuke Takayama ,  Koji Yamamoto ,  Hisashi Aoki

IPC: H04N5/93

CPC classification number: G11B27/28 ,  G06K9/00765 ,  H04N21/23418 ,  H04N21/8456

Abstract: A video processing apparatus calculates displayed time of two input segments having a telop area in a video on the basis of a time displayed area, determines whether or not the two input segments are a series of scene segments on the basis of the two displayed times, and outputs the two input segments determined as the series of scene segments as an output segment.

Abstract translation: 视频处理装置基于时间显示区域计算视频中具有字幕区域的两个输入段的显示时间，基于两个显示时间确定两个输入段是否是一系列场景段， 并输出确定为一系列场景段的两个输入段作为输出段。

公开(公告)号：US08625360B2

公开(公告)日：2014-01-07

申请号：US13165457

申请日：2011-06-21

Applicant: Hisashi Iwamoto ,  Yuji Yano ,  Koji Yamamoto

Inventor： Hisashi Iwamoto ,  Yuji Yano ,  Koji Yamamoto

IPC: G11C7/10

CPC classification number: G11C15/04

Abstract: To provide a semiconductor storage device capable of performing a search of the next data while performing a search of certain data. A first comparator compares data output to a bit line from a memory cell with first search data by activating a word line. A second comparator compares data output to a bit line from the memory cell with second search data by activating a word line. Data output to a bit line by the activation of one word line is input to both the first comparator and second comparator.

Abstract translation: 提供能够在执行某些数据的搜索的同时对下一个数据进行搜索的半导体存储装置。 第一比较器通过激活字线将来自存储器单元的数据输出与第一搜索数据进行比较。 第二比较器通过激活字线将来自存储器单元的数据输出与第二搜索数据进行比较。 通过一个字线的激活将数据输出到位线被输入到第一比较器和第二比较器。