公开(公告)号：US11793642B2

公开(公告)日：2023-10-24

申请号：US16522600

申请日：2019-07-25

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  David M. Taylor ,  Alexander J. Siegel ,  Christopher J. Olson ,  Sergio Delgado ,  Alexander H. Cooper ,  Lauren R. Freschauf ,  Asher L. Metchik ,  Matthew T. Winston ,  Cristobal R. Hernandez ,  Emil Karapetian ,  Bao Khuu ,  Eric Robert Dixon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2454 ,  A61F2/2463 ,  A61F2/2466 ,  A61F2220/0016 ,  A61F2310/00023

Abstract: In one representative embodiment, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. The spacer body can be made from braided, self-expandable metallic thread. A delivery apparatus can have a first shaft and a second shaft, wherein movement of the first shaft relative to the second shaft moves the anchor portion relative to the spacer body.

公开(公告)号：US11730596B2

公开(公告)日：2023-08-22

申请号：US17247676

申请日：2020-12-18

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  Matthew A. Peterson

IPC: A61F2/24 ,  A61F2/966

CPC classification number: A61F2/2436 ,  A61F2/24 ,  A61F2/2418 ,  A61F2/2412 ,  A61F2002/9665 ,  A61F2220/0008 ,  A61F2230/005 ,  A61F2230/0052 ,  A61F2230/0067 ,  A61F2230/0069

Abstract: A method of replacing the function of a native heart valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic valve is disposed along the distal end portion of the delivery apparatus. The prosthetic valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. The annular body includes three commissure support posts of fixed length that extend substantially the entire length of the annular body. A valve member is secured to the commissure support posts. The annular body is radially expanded within the native heart valve and the atrial and ventricular flanges are deployed on opposite sides of the native heart valve.

公开(公告)号：US11504229B2

公开(公告)日：2022-11-22

申请号：US16843122

申请日：2020-04-08

Applicant: Edwards Lifesciences Corporation

Inventor： Travis Zenyo Oba ,  Matthew A. Peterson ,  Glen T. Rabito ,  Alexander H. Cooper ,  David Robert Landon ,  J. Brent Ratz ,  Seung-Beom Yi

IPC: A61F2/24 ,  A61L27/04 ,  A61L27/36

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

公开(公告)号：US20220079749A1

公开(公告)日：2022-03-17

申请号：US17456532

申请日：2021-11-24

Applicant: Edwards Lifesciences Corporation

Inventor： Darshin S. Patel ,  Hannah Reed Bettencourt ,  Evan T. Schwartz ,  Sean Chow ,  Jocelyn Chau ,  Tri D. Tran ,  Alyssa Joy Gross ,  Yuanlong Du ,  Jason Seng-Che Lam ,  Alexander H. Cooper ,  Tram Ngoc Nguyen ,  Ngoc Huong Thi Nguyen ,  Kurt Kelly Reed ,  Corey Maurice Marshall

IPC: A61F2/24

Abstract: Systems, assemblies, and methods for treating valve regurgitation and other valve problems are described. Prosthetic valves can have integrated coverings or flanges. Prosthetic valves can have a flange attached to the inflow end of the annular frame and designed to extend outwardly therefrom. Docking devices can be used to repair or reshape native heart valves and to secure prosthetic heart valves at a specific location and position relative to a native heart valve. Delivery systems can be used to deploy a docking device into the heart, including a lubricous sleeve in the delivery system. Packaging and storage systems suitable for the delivery systems are described.

公开(公告)号：US20210128300A1

公开(公告)日：2021-05-06

申请号：US17247676

申请日：2020-12-18

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  Matthew A. Peterson

IPC: A61F2/24

Abstract: A method of replacing the function of a native heart valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic valve is disposed along the distal end portion of the delivery apparatus. The prosthetic valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. The annular body includes three commissure support posts of fixed length that extend substantially the entire length of the annular body. A valve member is secured to the commissure support posts. The annular body is radially expanded within the native heart valve and the atrial and ventricular flanges are deployed on opposite sides of the native heart valve.

公开(公告)号：US20210022863A1

公开(公告)日：2021-01-28

申请号：US17071745

申请日：2020-10-15

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  David Robert Landon ,  Kevin M. Stewart ,  Garrett Dallas Johnson ,  Glen T. Rabito ,  Tarannum Ishaq Gutierrez ,  Hiroshi Okabe ,  Ramon Aguilar, JR. ,  Jesse Robert Edwards ,  Taylor Jacob Scheinblum ,  Patrick Chow ,  Julio Cesar Sanchez ,  Hieu Minh Luong

IPC: A61F2/24 ,  A61M25/00 ,  A61M25/01

Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The steerable delivery system can contain a steerable rail configured for multi-plane bending to direct a distal end of the delivery system.

公开(公告)号：US20200297481A1

公开(公告)日：2020-09-24

申请号：US16843122

申请日：2020-04-08

Applicant: Edwards Lifesciences Corporation

Inventor： Travis Zenyo Oba ,  Matthew A. Peterson ,  Glen T. Rabito ,  Alexander H. Cooper ,  David Robert Landon ,  J. Brent Ratz ,  Seung-Beom Yi

IPC: A61F2/24 ,  A61L27/04 ,  A61L27/36

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

公开(公告)号：US10687939B2

公开(公告)日：2020-06-23

申请号：US16015003

申请日：2018-06-21

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  Matthew A. Peterson ,  William C. Brunnett

IPC: A61F2/24 ,  A61F2/95

Abstract: Embodiments of a prosthetic heart valve comprise an annular main body, an atrial cap extending radially outwardly from the atrial end of the main body, and a plurality of ventricular anchors extending outwardly from the ventricular end of the main body. Each ventricular anchor can have a proximal end portion connected to the ventricular end, an intermediate portion extending away from the atrial end and then back toward the atrial so as to define a first bend, and a free distal end portion that extends from the intermediate portion. The distal end portion can comprise a first section, a second section, and a second bend between the first and second sections, the first section extending from the intermediate portion in a direction toward the atrial end and radially away from the main body.

公开(公告)号：US10350062B2

公开(公告)日：2019-07-16

申请号：US15653390

申请日：2017-07-18

Applicant: Edwards Lifesciences Corporation

Inventor： Matthew A. Peterson ,  Seung-Beom Yi ,  Siddharth Vad ,  Travis Zenyo Oba ,  Lauren R. Freschauf ,  Amanda French ,  Yaron Keidar ,  Yuanlong Du ,  Gregory Bak-Boychuk ,  Kevin M. Golemo ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.

公开(公告)号：US10278819B2

公开(公告)日：2019-05-07

申请号：US15167760

申请日：2016-05-27

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.