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公开(公告)号：US11364212B2
公开(公告)日：2022-06-21
申请号：US17132825
申请日：2020-12-23
发明人： Swati Kulkarni , Bijay Kumar Padhi , Shanvas Alikunju , Rajeev Singh Raghuvanshi , Srinivas Ramchandra Sidgiddi , Anirudh Gautam
IPC分类号： A61K31/165 , A61P17/02 , A61P17/06 , A61P17/10 , A61K31/65 , A61P17/04 , A61P17/00 , A61P29/00 , A61K9/00
摘要： The present application relates to a method of treating an inflammatory skin condition by administering a pharmaceutical composition comprising a reduced dose of minocycline to a subject in need thereof, wherein said administration provides an effective plasma or interstitial fluid concentration of minocycline for treating the inflammatory skin condition.
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公开(公告)号：US20160136187A1
公开(公告)日：2016-05-19
申请号：US14946715
申请日：2015-11-19
CPC分类号： A61K31/65 , A61K9/0053 , A61K9/4816 , A61K9/4866 , A61K9/5078
摘要： Doxycycline formulations with a reduced food effect are disclosed. Particularly disclosed are modified release formulations which can be administered once a day and exhibit a reduced food effect. Methods of treating inflammatory conductions such as rosacea or inflammatory symptoms such as the papules and pustules of rosacea or acne vulgaris are also disclosed.
摘要翻译： 公开了具有降低的食物效应的强力霉素制剂。 特别公开的是可以每天施用一次并显示降低的食物效果的调制释放制剂。 还公开了治疗诸如红斑痤疮或炎性症状的炎症传导的方法，例如红斑痤疮或寻常型痤疮的丘疹和脓疱。
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公开(公告)号：US10905664B2
公开(公告)日：2021-02-02
申请号：US16827622
申请日：2020-03-23
发明人： Swati Kulkarni , Bijay Kumar Padhi , Shanvas Alikunju , Rajeev Singh Raghuvanshi , Srinivas Ramchandra Sidgiddi , Anirudh Gautam
IPC分类号： A61K31/165 , A61P17/02 , A61P17/06 , A61P17/10 , A61K31/65 , A61P17/04 , A61P17/00 , A61P29/00 , A61K9/00
摘要： The present application relates to a method of treating an inflammatory skin condition by administering a pharmaceutical composition comprising a reduced dose of minocycline to a subject in need thereof, wherein said administration provides an effective plasma or interstitial fluid concentration of minocycline for treating the inflammatory skin condition.
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公开(公告)号：US09949990B2
公开(公告)日：2018-04-24
申请号：US15712415
申请日：2017-09-22
IPC分类号： A61K31/40 , A61K31/635 , A61K47/10 , A61K47/44 , A61K47/14 , A61K47/26 , A61K9/08 , A61K9/00
CPC分类号： A61K31/635 , A61K9/0053 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K31/415 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
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公开(公告)号：US20170071930A1
公开(公告)日：2017-03-16
申请号：US14443525
申请日：2013-11-19
IPC分类号： A61K31/4709 , A61K9/20 , A61K9/48
CPC分类号： A61K31/4709 , A61K9/16 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/435 , A61K31/437 , A61K31/444 , A61K31/47 , A61K31/497 , A61K31/506 , A61K31/53 , A61K31/5377
摘要： The present application discloses a pharmaceutical composition comprising a class of CETP inhibitors with improved oral bioavailability. The application further discloses compositions comprising a class of CETP inhibitor and at least one solubility improving material and optionally one or more wetting agents.
摘要翻译： 本申请公开了包含一类具有改善的口服生物利用度的CETP抑制剂的药物组合物。 本申请进一步公开了包含一类CETP抑制剂和至少一种溶解度改善材料以及任选的一种或多种润湿剂的组合物。
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公开(公告)号：US10376527B2
公开(公告)日：2019-08-13
申请号：US15922170
申请日：2018-03-15
IPC分类号： A61K31/635 , A61K47/14 , A61K47/44 , A61K9/00 , A61K9/08 , A61K47/10 , A61K9/10 , A61K31/415 , A61K47/26 , C07D231/12
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
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公开(公告)号：US09572819B2
公开(公告)日：2017-02-21
申请号：US15167922
申请日：2016-05-27
CPC分类号： A61K31/635 , A61K9/0053 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K31/415 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
摘要翻译： 本发明涉及塞来昔布或其药学上可接受的盐的稳定的口服液体药物组合物。 存在于如本文所述的组合物中的塞来考昔在pH 2.0，温度为37℃±0.5℃，并以50rpm的速度搅拌下在禁食状态模拟胃液（FaSSGF）中经受时不显示任何沉淀 至少60分钟。 它还涉及使用塞来昔布组合物的制备方法和方法。
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公开(公告)号：US09532996B2
公开(公告)日：2017-01-03
申请号：US14946715
申请日：2015-11-19
CPC分类号： A61K31/65 , A61K9/0053 , A61K9/4816 , A61K9/4866 , A61K9/5078
摘要： Doxycycline formulations with a reduced food effect are disclosed. Particularly disclosed are modified release formulations which can be administered once a day and exhibit a reduced food effect. Methods of treating inflammatory conductions such as rosacea or inflammatory symptoms such as the papules and pustules of rosacea or acne vulgaris are also disclosed.
摘要翻译： 公开了具有降低的食物效应的强力霉素制剂。 特别公开的是可以每天施用一次并显示降低的食物效果的调制释放制剂。 还公开了治疗诸如红斑痤疮或炎性症状的炎症传导的方法，例如红斑痤疮或寻常型痤疮的丘疹和脓疱。
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公开(公告)号：US11103517B2
公开(公告)日：2021-08-31
申请号：US15093673
申请日：2016-04-07
摘要： The present application relates to a method of orally administering once daily tablet of minocycline to a subject in need thereof, wherein said tablet is substantially free of lactose. The present application also relates to processes for preparing said once daily tablet of minocycline that provides reduced stock keeping units with improved inventory by supplying multiple doses of minocycline in single tablet.
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公开(公告)号：US10799517B2
公开(公告)日：2020-10-13
申请号：US15922353
申请日：2018-03-15
IPC分类号： A61K31/415 , A61K31/635 , A61K47/14 , A61K47/44 , A61K9/00 , A61K9/08 , A61K47/10 , A61K9/10 , A61K47/26 , C07D231/12
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
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