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公开(公告)号：US09949990B2
公开(公告)日：2018-04-24
申请号：US15712415
申请日：2017-09-22
IPC分类号： A61K31/40 , A61K31/635 , A61K47/10 , A61K47/44 , A61K47/14 , A61K47/26 , A61K9/08 , A61K9/00
CPC分类号： A61K31/635 , A61K9/0053 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K31/415 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
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公开(公告)号：US10376527B2
公开(公告)日：2019-08-13
申请号：US15922170
申请日：2018-03-15
IPC分类号： A61K31/635 , A61K47/14 , A61K47/44 , A61K9/00 , A61K9/08 , A61K47/10 , A61K9/10 , A61K31/415 , A61K47/26 , C07D231/12
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
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公开(公告)号：US09572819B2
公开(公告)日：2017-02-21
申请号：US15167922
申请日：2016-05-27
CPC分类号： A61K31/635 , A61K9/0053 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K31/415 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
摘要翻译： 本发明涉及塞来昔布或其药学上可接受的盐的稳定的口服液体药物组合物。 存在于如本文所述的组合物中的塞来考昔在pH 2.0，温度为37℃±0.5℃，并以50rpm的速度搅拌下在禁食状态模拟胃液（FaSSGF）中经受时不显示任何沉淀 至少60分钟。 它还涉及使用塞来昔布组合物的制备方法和方法。
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公开(公告)号：US10799517B2
公开(公告)日：2020-10-13
申请号：US15922353
申请日：2018-03-15
IPC分类号： A61K31/415 , A61K31/635 , A61K47/14 , A61K47/44 , A61K9/00 , A61K9/08 , A61K47/10 , A61K9/10 , A61K47/26 , C07D231/12
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
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公开(公告)号：US20160346301A1
公开(公告)日：2016-12-01
申请号：US15167922
申请日：2016-05-27
IPC分类号： A61K31/635 , A61K9/08 , A61K9/00 , A61K47/14 , A61K47/44
CPC分类号： A61K31/635 , A61K9/0053 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K31/415 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
摘要翻译： 本发明涉及塞来昔布或其药学上可接受的盐的稳定的口服液体药物组合物。 存在于如本文所述的组合物中的塞来考昔在pH 2.0，温度为37℃±0.5℃，并以50rpm的速度搅拌下在禁食状态模拟胃液（FaSSGF）中经受时不显示任何沉淀 至少60分钟。 它还涉及使用塞来昔布组合物的制备方法和方法。
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公开(公告)号：US10722456B2
公开(公告)日：2020-07-28
申请号：US15607216
申请日：2017-05-26
IPC分类号： A61K9/00 , A61K9/16 , A61K31/415 , A61K31/635 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/44 , A61K9/10 , C07D231/12
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
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公开(公告)号：US09795620B2
公开(公告)日：2017-10-24
申请号：US15374951
申请日：2016-12-09
IPC分类号： A61K31/40 , A61K31/635 , A61K9/00 , A61K9/08 , A61K47/26 , A61K47/14 , A61K47/44 , A61K47/10
CPC分类号： A61K31/635 , A61K9/0053 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K31/415 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
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公开(公告)号：US20170119798A1
公开(公告)日：2017-05-04
申请号：US15374951
申请日：2016-12-09
CPC分类号： A61K31/635 , A61K9/0053 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K31/415 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.
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