公开(公告)号：US12006504B2

公开(公告)日：2024-06-11

申请号：US17669945

申请日：2022-02-11

申请人： DSM IP Assets B.V. ,  DOW AgroSciences LLC

发明人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Paul G. Roessler ,  James George Metz ,  Scott Bevan ,  Jerry M. Kuner

IPC分类号： C12N15/82 ,  C12P7/6427 ,  C12N9/10 ,  C12N9/12

CPC分类号： C12N15/8247 ,  C12P7/6427 ,  C12N9/1029 ,  C12N9/1288

摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).

公开(公告)号：US10669554B2

公开(公告)日：2020-06-02

申请号：US15825107

申请日：2017-11-29

申请人： Dow AgroSciences LLC ,  DSM IP ASSETS B.V.

发明人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Paul Gordon Roessler ,  James Metz ,  Scott Bevan ,  Jerry Kuner

IPC分类号： C12N15/82 ,  C12P7/64 ,  C12N9/10 ,  C12N9/12

摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).

公开(公告)号：US20190010510A1

公开(公告)日：2019-01-10

申请号：US16139534

申请日：2018-09-24

申请人： DSM IP Assets B.V. ,  Dow AgroSciences LLC

发明人： Terence A WALSH ,  Daniel Gachotte ,  Ann Owens Merlo ,  Paul G. Roessler ,  James Metz ,  Scott Bevan ,  Jerry Kuner

IPC分类号： C12N15/82 ,  C12P7/64 ,  C12N9/10 ,  C12N9/12

摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).

公开(公告)号：US11168332B2

公开(公告)日：2021-11-09

申请号：US16890740

申请日：2020-06-02

申请人： Dow AgroSciences LLC ,  DSM IP ASSETS B.V.

发明人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Paul Gordon Roessler ,  James Metz ,  Scott Bevan ,  Jerry Kuner

IPC分类号： C12N15/82 ,  C12P7/64 ,  C12N9/10 ,  C12N9/12

摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).

公开(公告)号：US20180310512A9

公开(公告)日：2018-11-01

申请号：US14726285

申请日：2015-05-29

申请人： Dow AgroSciences LLC ,  DSM IP ASSETS B.V.

发明人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Dayakar Reddy Pareddy ,  James Metz ,  Scott Bevan ,  Jerry Kuner

IPC分类号： A01H5/10 ,  A61K31/202 ,  C12N15/82 ,  C12N9/12 ,  C12N9/10 ,  A23L1/20

CPC分类号： C12N15/8247 ,  A01H5/10 ,  A23L11/07 ,  A23V2002/00 ,  A61K31/202 ,  C12N9/1029 ,  C12N9/1288 ,  C12P7/6427 ,  C12P7/6472 ,  C12Y203/01085

摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：US20180073036A1

公开(公告)日：2018-03-15

申请号：US15825107

申请日：2017-11-29

申请人： Dow AgroSciences LLC ,  DSM IP ASSETS B.V.

发明人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Dayakar Reddy Pareddy ,  James Metz ,  Scott Bevan ,  Jerry Kuner

IPC分类号： C12N15/82 ,  C12P7/64 ,  C12N9/10 ,  C12N9/12

摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed),

公开(公告)号：US11046968B2

公开(公告)日：2021-06-29

申请号：US16006485

申请日：2018-06-12

申请人： Dow AgroSciences LLC ,  DSM IP Assets B.V.

发明人： Terence A. Walsh ,  Daniel J. Gachotte ,  Cory M. Larsen ,  Scott Bevan ,  P. Ann Owens-Merlo ,  James G. Metz ,  Ross Zirkle

IPC分类号： C12N15/82 ,  A23D9/00 ,  C12N9/12 ,  A23K20/158 ,  C11B1/00 ,  C11B1/04 ,  C11B1/10 ,  C12N9/10

摘要： This disclosure concerns recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：US20180282711A1

公开(公告)日：2018-10-04

申请号：US16006485

申请日：2018-06-12

申请人： Dow AgroSciences LLC ,  DSM IP Assets B.V.

发明人： Terence A. Walsh ,  Daniel J. Gachotte ,  Cory M. Larsen ,  Scott Bevan ,  P. Ann Owens-Merlo ,  James G. Metz ,  Ross Zirkle

IPC分类号： C12N9/10 ,  C12N15/82 ,  C12N9/12 ,  C11B1/04 ,  C11B1/00 ,  A23K20/158 ,  A23D9/00 ,  C11B1/10

摘要： This disclosure concerns recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：US09994828B2

公开(公告)日：2018-06-12

申请号：US14555326

申请日：2014-11-26

申请人： Dow AgroSciences LLC ,  DSM IP Assets B.V.

发明人： Terence A. Walsh ,  Daniel J. Gachotte ,  Cory M. Larsen ,  Scott Bevan ,  P. Ann Owens-Merlo ,  James G. Metz ,  Ross Zirkle

IPC分类号： C12N9/10 ,  C12N15/82 ,  A23D9/00 ,  C11B1/00 ,  C11B1/04 ,  C11B1/10 ,  A23K20/158 ,  C12N9/12

CPC分类号： C12N9/1029 ,  A23D9/00 ,  A23K20/158 ,  C11B1/00 ,  C11B1/04 ,  C11B1/10 ,  C12N9/1288 ,  C12N15/82 ,  C12N15/8247 ,  C12Y203/01085

摘要： This disclosure concerns recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：US20150320003A1

公开(公告)日：2015-11-12

申请号：US14726285

申请日：2015-05-29

申请人： Dow AgroSciences LLC ,  DSM IP ASSETS B.V.

发明人： Terence A. Walsh ,  Daniel Gachotte ,  Ann Owens Merlo ,  Dayakar Reddy Pareddy ,  James Metz ,  Scott Bevan ,  Jerry Kuner

IPC分类号： A01H5/10 ,  A23L1/20 ,  C12N9/12 ,  C12N9/10 ,  A61K31/202 ,  C12N15/82

CPC分类号： C12N15/8247 ,  A01H5/10 ,  A23L11/07 ,  A23V2002/00 ,  A61K31/202 ,  C12N9/1029 ,  C12N9/1288 ,  C12P7/6427 ,  C12P7/6472 ,  C12Y203/01085

摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.

摘要翻译： 本发明提供了用多不饱和脂肪酸（PUFA）合成酶遗传修饰的重组宿主生物体，以及允许和/或改善宿主生物体中PUFA生产的一种或多种辅助蛋白质。 本发明还涉及制造和使用这些生物体以及从这些生物获得的产品的方法。