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公开(公告)号：US12006504B2
公开(公告)日：2024-06-11
申请号：US17669945
申请日：2022-02-11
发明人： Terence A. Walsh , Daniel Gachotte , Ann Owens Merlo , Paul G. Roessler , James George Metz , Scott Bevan , Jerry M. Kuner
IPC分类号： C12N15/82 , C12P7/6427 , C12N9/10 , C12N9/12
CPC分类号： C12N15/8247 , C12P7/6427 , C12N9/1029 , C12N9/1288
摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).
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公开(公告)号：US10968437B2
公开(公告)日：2021-04-06
申请号：US16107108
申请日：2018-08-21
申请人： DSM IP Assets B.V.
IPC分类号： C07H21/04 , C12N9/20 , C12N15/82 , C12N15/79 , C12N9/10 , C12N9/16 , A61K31/202 , C07K14/405 , A23L33/115 , C12P7/64 , C07K14/00 , C07K14/195
摘要： Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.
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公开(公告)号：US10087430B2
公开(公告)日：2018-10-02
申请号：US15112885
申请日：2015-01-28
申请人： DSM IP Assets B.V.
IPC分类号： C12N9/20 , C12N9/16 , A61K31/202 , C07K14/405 , C12P7/64 , A23L33/115 , C07K14/00 , C12N15/79
摘要： Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.
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