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26 条记录 (耗时 0.027 秒)

    Patterned binding of functionalized microspheres for optical diffraction-based biosensors
    1.
    发明授权
    Patterned binding of functionalized microspheres for optical diffraction-based biosensors 有权
    用于光学衍射的生物传感器的官能化微球的图案化结合

    公开(公告)号：US06573040B2

    公开(公告)日：2003-06-03

    申请号：US09733204

    申请日：2000-12-08

    申请人： Dennis S. Everhart ,  Rosann M. Kaylor ,  Kevin McGrath

    发明人： Dennis S. Everhart ,  Rosann M. Kaylor ,  Kevin McGrath

    IPC分类号： G01N33567

    CPC分类号： G01N33/54346 ,  B01J2219/00382 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  C40B60/14 ,  G01N21/4788 ,  G01N33/54373 ,  G01N33/553

    摘要： The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capable of binding with a target analyte. Additionally, the system comprises a polymer film, which may include a metal coating, upon which is printed a specific, predetermined pattern of a analyte-specific receptors. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.

    摘要翻译： 本发明提供了用于检测介质中存在的分析物的廉价且敏感的系统和方法。 该系统包括衍射增强元件，例如功能化微球，其被修饰使得它们能够与靶分析物结合。 此外，该系统包括聚合物膜，其可以包括金属涂层，在其上印刷特定的预定图案的分析物特异性受体。 当将目标分析物直接或与衍射增强元件连接到聚合物膜的选择区域时，透射和/或反射光的衍射通过物理尺寸和限定的精确放置分析物而发生。 产生可以用眼睛或可选地用感测装置容易地看到的衍射图像。

    Caffeine adsorbent liquid filter with integrated adsorbent
    4.
    发明授权
    Caffeine adsorbent liquid filter with integrated adsorbent 失效
    咖啡因吸附剂液体过滤器与集成吸附剂

    公开(公告)号：US5603830A

    公开(公告)日：1997-02-18

    申请号：US448801

    申请日：1995-05-24

    申请人： Dennis S. Everhart ,  Rosann M. Kaylor ,  Kenneth R. Smith

    发明人： Dennis S. Everhart ,  Rosann M. Kaylor ,  Kenneth R. Smith

    IPC分类号： A23F3/38 ,  A23F5/22 ,  B01J20/28 ,  B01D39/00

    CPC分类号： B01J20/28028 ,  A23F3/385 ,  A23F5/223 ,  B01J20/28033

    摘要： An adsorbent filter for removing caffeine from liquids. The filter is composed of a matrix of fibrous material; and adsorbent particulate material integrated within the matrix of fibrous material, so that passage of a liquid having a caffeine concentration ranging from about 20 to about 100 mg per 100 mL of liquid through the matrix for a contact time of less than about 2 minutes results in at least a 40 percent reduction in the caffeine concentration of the liquid. The matrix of fibrous material may be selected from woven fabrics, knit fabrics and nonwoven fabrics. The adsorbent material may be clay minerals such as, for example, smectite clay minerals. Examples of smectite clay minerals include, bentonite clays and montmorillonite clays. Generally speaking, the filter can be adapted to provide at least a 40 percent reduction in the caffeine concentration for about 1 cup to about 40 cups of a liquid.

    摘要翻译： 用于从液体中去除咖啡因的吸附剂过滤器。 过滤器由纤维材料基体组成; 以及整合在纤维材料基质内的吸附剂颗粒材料，使得咖啡因浓度范围为每100mL液体约20至约100mg的液体通过基质，接触时间小于约2分钟，导致 咖啡因浓度至少降低40％。 纤维材料的基质可以选自机织织物，针织织物和非织造织物。 吸附剂材料可以是粘土矿物，例如蒙脱石粘土矿物。 蒙皂石粘土矿物的实例包括膨润土和蒙脱石粘土。 一般来说，过滤器可以适合于提供约1杯至约40杯液体的咖啡因浓度的至少40％的降低。

    Gel sensors and method of use thereof
    5.
    发明授权
    Gel sensors and method of use thereof 失效
    凝胶传感器及其使用方法

    公开(公告)号：US06180288B2

    公开(公告)日：2001-01-30

    申请号：US08821464

    申请日：1997-03-21

    申请人： Dennis S. Everhart ,  Rosann M. Kaylor ,  Mark L. Jones

    发明人： Dennis S. Everhart ,  Rosann M. Kaylor ,  Mark L. Jones

    IPC分类号： G03F716

    CPC分类号： G03F7/00 ,  B82Y10/00 ,  B82Y40/00 ,  G01N33/54373 ,  G03F7/0002 ,  G03F7/165 ,  G03H2001/0033

    摘要： The present invention comprises an optically diffracting sensing device whose diffraction pattern changes upon exposure to some stimuli. The diffraction pattern may be two or three dimensional, and in one embodiment the change in diffraction patterns is recognizable to the untrained eye. The device comprises one or more gels coated onto patterned, self-assembling monolayers of alkanethiolates, carboxylic acids, hydroxamic acids, and phosphonic acids printed onto a variety of substrates, including glass, silicon, aluminum oxide, and thermoplastic films metallized with gold, or with an alloy such as nickel/gold. The present invention also comprises the method of making this device, and the use of this device.

    摘要翻译： 本发明包括一种光学衍射感测装置，其衍射图案在暴露于一些刺激物时改变。 衍射图案可以是二维或三维，并且在一个实施例中，未经训练的眼睛可以识别衍射图案的变化。 该装置包括一个或多个涂布在图案化的自组装单链烷烃硫醇盐，羧酸，异羟肟酸和膦酸上的凝胶，印刷在各种基材上，包括用金金属化的玻璃，硅，氧化铝和热塑性薄膜，或 使用镍/金等合金。 本发明还包括制造该装置的方法以及该装置的使用。

    Nonwoven fabric formed from alloy fibers
    8.
    发明授权
    Nonwoven fabric formed from alloy fibers 失效
    由合金纤维形成的无纺布

    公开(公告)号：US5534335A

    公开(公告)日：1996-07-09

    申请号：US320098

    申请日：1994-10-07

    申请人： Dennis S. Everhart ,  Mary L. Delucia ,  Terry K. Timmons ,  Robert D. Wright

    发明人： Dennis S. Everhart ,  Mary L. Delucia ,  Terry K. Timmons ,  Robert D. Wright

    IPC分类号： D01F8/06 ,  D01F8/12 ,  D04H1/42 ,  D04H1/54 ,  D03D3/00

    CPC分类号： D04H1/54 ,  D01F8/06 ,  D01F8/12 ,  D04H1/4291 ,  D04H1/4334 ,  D04H1/4374 ,  D04H1/4382 ,  Y10T428/2929 ,  Y10T428/2933 ,  Y10T442/622 ,  Y10T442/66 ,  Y10T442/68 ,  Y10T442/681

    摘要： A nonwoven fabric is provided which is made from fibers comprising at least two thermoplastic polymers and a compatibilizer. One of the thermoplastic polymers is present as a dominant continuous phase and the other one or more polymers are present as a non-continuous phase or phases. The polymer of the non-continuous phase or phases has a polymer melt temperature less than 30.degree. C. below the polymer melt temperature of the continuous phase. The polymer of the dominant phase may be, for example, polypropylene and the non-continuous phase may be, for example, polyamide. The compatibilizer may be one of several such as zinc ionomers of ethylenemethacrylic acid or modified polypropylene with maleic anhydride. The fibers from which the fabric is made are generally between about 5 and 50 microns in diameter and the non-continuous phase may exist within the continuous phase as fibrils with a cross-sectional area at least 0.1% of the cross-sectional area of the fiber.

    摘要翻译： 提供由包含至少两种热塑性聚合物和增容剂的纤维制成的非织造织物。 一种热塑性聚合物作为显性连续相存在，而另一种或多种聚合物作为非连续相或相存在。 非连续相或聚合物的聚合物的聚合物熔体温度低于连续相聚合物熔体温度30℃以下。 主要相的聚合物可以是例如聚丙烯，非连续相可以是例如聚酰胺。 增容剂可以是几种之一，例如乙烯·甲基丙烯酸的锌离聚物或具有马来酸酐的改性聚丙烯。 制造织物的纤维通常在直径约5至50微米之间，并且非连续相可以作为原纤维存在于连续相中，其中横截面积为截面面积的至少0.1％ 纤维。

    Method of applying a protein coating to a substrate and article thereof
    9.
    发明授权
    Method of applying a protein coating to a substrate and article thereof 失效
    将蛋白质涂层施用于基材及其制品的方法

    公开(公告)号：US5494744A

    公开(公告)日：1996-02-27

    申请号：US321485

    申请日：1994-10-12

    申请人： Dennis S. Everhart ,  Kristi L. Kiick-Fischer

    发明人： Dennis S. Everhart ,  Kristi L. Kiick-Fischer

    IPC分类号： D06B3/22 ,  A61L15/32 ,  B05D1/18 ,  C08J7/00 ,  C08J7/04 ,  C08J9/36 ,  D06M15/15 ,  D06M23/00 ,  D06N3/12 ,  B32B15/00

    CPC分类号： B82Y30/00 ,  B05D1/185 ,  B82Y40/00 ,  D06M15/15 ,  D06M23/005 ,  D06N3/12 ,  Y02P20/582 ,  Y10T428/266 ,  Y10T428/269 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31935 ,  Y10T428/31938

    摘要： Disclosed is a method of coating a permeable sheet with amphiphilic proteins, the method including the steps of: 1) providing a permeable sheet having a plurality of individual exposed surfaces, at least a portion of which having relatively low surface energies; 2) providing an aqueous solution containing amphiphilic proteins, the solution having a relatively high surface tension; and 3) contacting the solution containing amphiphilic proteins under shear stress conditions with the matrix of fibrous material so that at least a portion of the amphiphilic proteins are adsorbed onto at least some individual exposed surfaces. Also disclosed is a protein-coated permeable sheet composed of: 1) a permeable sheet having a plurality of individual exposed surfaces, at least a portion of which having relatively low surface energies; and 2) amphiphilic proteins adsorbed onto at least some individual exposed surfaces to define a gradient distribution of amphiphilic protein coating along at least one dimension of the permeable sheet.

    摘要翻译： 公开了一种用两亲性蛋白质涂覆可渗透片材的方法，所述方法包括以下步骤：1）提供具有多个单个暴露表面的可渗透片材，其至少一部分具有相对较低的表面能; 2）提供含有两亲性蛋白质的水溶液，该溶液具有相对较高的表面张力; 和3）在剪切应力条件下使包含两亲蛋白质的溶液与纤维材料基质接触，使得至少一部分两亲性蛋白质吸附在至少一些单独的暴露表面上。 还公开了一种蛋白质包覆的可渗透片，其由以下组成：1）具有多个单独暴露表面的可渗透片，其至少一部分具有相对较低的表面能; 和2）两亲性蛋白质吸附到至少一些个体暴露的表面上以限定沿着可渗透片材的至少一个维度的两亲性蛋白质涂层的梯度分布。

    Multilayer nonwoven laminiferous structure
    10.
    发明授权
    Multilayer nonwoven laminiferous structure 失效
    多层非织造层状结构

    公开(公告)号：US5149576A

    公开(公告)日：1992-09-22

    申请号：US618354

    申请日：1990-11-26

    申请人： David C. Potts ,  George A. Young ,  Dennis S. Everhart ,  J. Gavin MacDonald ,  Ronald S. Nohr

    发明人： David C. Potts ,  George A. Young ,  Dennis S. Everhart ,  J. Gavin MacDonald ,  Ronald S. Nohr

    IPC分类号： B32B5/26 ,  D04H13/00

    CPC分类号： B32B5/26 ,  D04H1/42 ,  D04H1/559 ,  D04H1/56 ,  D04H3/005 ,  Y10T428/24826 ,  Y10T428/31 ,  Y10T428/31544 ,  Y10T428/31663 ,  Y10T442/62 ,  Y10T442/659 ,  Y10T442/671

    摘要： A nonwoven laminiferous structure is provided which has at least two melt-extruded nonwoven layers:(A) a first layer which includes at least a portion of a first nonwoven web; and(B) a second layer adjacent to said first layer which includes at least a portion of a second nonwoven web; in which,(1) the boundary between any two adjacent melt-extruded nonwoven layers is distinct in that fibers at or near the surfaces of such adjacent layer are not significantly intermingled;(2) the fibers of at least one of such first and second layers are prepared by melt extrusion through a die at a shear rate of from about 50 to about 30,000 sec.sup.-1 and a throughput of no more than about 5.4 kg/cm/hour of a mixture of an additive and a thermoplastic polymer, which additive (a) is present at a level of from about 0.05 to about 15 percent by weight, based on the amount of thermoplastic polymer, and (b) imparts to the surfaces of the fibers, as a consequence of the preferential migration of the additive to the surfaces of the fibers as they are formed, at least one characteristic which is different from the surface characteristics of fibers prepared from the thermoplastic polymer alone, said preferential migration taking place spontaneously upon the formation of the fibers without the need for a post-formation treatment of any kind;(3) the additive present in any melt-extruded nonwoven layer does not migrate to an adjacent layer to a significant degree in use, so that the surface characteristics of each layer remain substantially as originally prepared;(4) the thermoplastic polymer is elected from the group consisting of polyolefins, polyesters, polyetheresters, and polyamides; and(5) the laminiferous structure has been pattern bonded by the application of heat and pressure.

    摘要翻译： 提供了一种非织造层状结构，其具有至少两个熔融挤出非织造层：（A）第一层，其包括第一非织造纤维网的至少一部分; 和（B）邻近所述第一层的第二层，其包括第二非织造纤维网的至少一部分; 其中，（1）任何两个相邻的熔融挤出非织造层之间的边界是不同的，因为在相邻层的表面处或附近的纤维没有明显混合; （2）这样的第一和第二层中的至少一个的纤维通过熔融挤出通过模具以约50至约30,000秒-1的剪切速率和不超过约5.4kg / cm 2的生产量来制备， 添加剂和热塑性聚合物的混合物的小时，该添加剂（a）以基于热塑性聚合物的量的约0.05至约15重量％的量存在，和（b）赋予 作为添加剂在形成纤维表面时优先迁移到纤维表面的结果，纤维具有与单独由热塑性聚合物制备的纤维的表面特性不同的至少一个特征，所述优先迁移自发地发生 在形成纤维时，不需要任何形式的后处理; （3）存在于任何熔融挤出的非织造层中的添加剂在使用中不会显着地迁移到相邻层，使得每层的表面特性基本上保持原样制备; （4）热塑性聚合物选自聚烯烃，聚酯，聚醚酯和聚酰胺; 和（5）通过施加热和压力将层状结构图案结合。