公开(公告)号：US5625064A

公开(公告)日：1997-04-29

申请号：US458550

申请日：1995-06-02

申请人： David R. Andrews ,  Dinesh Gala ,  Jacques Gosteli ,  Frank Guenter ,  William Leong ,  Ingrid Mergelsberg ,  Anantha Sudhakar

发明人： David R. Andrews ,  Dinesh Gala ,  Jacques Gosteli ,  Frank Guenter ,  William Leong ,  Ingrid Mergelsberg ,  Anantha Sudhakar

IPC分类号： C07D249/12 ,  C07D521/00 ,  C07D403/10

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D249/12

摘要： Described is a process for preparing triazolone compounds of the formula ##STR1## comprising heating a mixture of a compound of the formula ##STR2## and a hydrazine derivative of the formula R.sup.5 --NH--NH--CHO, R.sup.5 --NH--NH--C(O)OC(CH.sub.3).sub.3 or R.sup.5 --NH--NH--C(O)OCH.sub.2 C.sub.6 H.sub.5, optionally in the presence of an added base.

摘要翻译： 描述了制备下式的三唑酮化合物的方法：包括加热式IMA化合物与式R 5 -NH-NH-CHO，R 5 -NH-NH-C（ O）OC（CH 3）3或R 5 -NH-NH-C（O）OCH 2 C 6 H 5，任选地在加入的碱的存在下。

公开(公告)号：US06713481B1

公开(公告)日：2004-03-30

申请号：US09166445

申请日：1998-10-05

申请人： David R. Andrews ,  William Leong ,  Anantha Sudhakar

发明人： David R. Andrews ,  William Leong ,  Anantha Sudhakar

IPC分类号： A61K31496

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

摘要： The crystalline polymorph Form I of (−)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one represented by the formula I pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.

摘要翻译： （ - ） - 4- [4- [4- [4 - [[（2R-顺式）-5-（2,4-二氟苯基）四氢-5-（1H-1,2,4 - 三唑-1-基甲基）呋喃-3-基]甲氧基]苯基] -1-哌嗪基]苯基-2,4-二氢-2 - [（S）-1-乙基-2（S） - 羟基丙基] -3H 公开了由含有这种多晶型的式I药物组合物所代表的-1,2,4-三唑-3-酮和使用这种多晶型物治疗哺乳动物真菌感染的方法。

公开(公告)号：US06958337B2

公开(公告)日：2005-10-25

申请号：US10786886

申请日：2004-02-25

申请人： David R. Andrews ,  William Leong ,  Anantha Sudhakar

发明人： David R. Andrews ,  William Leong ,  Anantha Sudhakar

IPC分类号： C07D521/00 ,  A61K31/496 ,  C07D405/14

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

摘要： The crystalline polymorph Form I of (−)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one represented by the formula I pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.

摘要翻译： （ - ） - 4- [4- [4- [4 - [[（2R-顺式）-5-（2,4-二氟苯基）四氢-5-（1H-1,2,4 - 三唑-1-基甲基）呋喃-3-基]甲氧基]苯基] -1-哌嗪基]苯基-2,4-二氢-2 - [（S）-1-乙基-2（S） - 羟基丙基] -3H 公开了由式I表示的1,2,4-三唑-3-酮包含这种多晶型物的药物组合物和使用这种多晶型物治疗哺乳动物真菌感染的方法。

公开(公告)号：US6064599A

公开(公告)日：2000-05-16

申请号：US179254

申请日：1998-10-26

申请人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. Mc Clintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

发明人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. Mc Clintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

IPC分类号： G01R31/3185 ,  G11C8/12 ,  H03K19/094 ,  H03K19/173 ,  H03K19/177 ,  G11C13/00

CPC分类号： H03K19/09429 ,  G11C8/12 ,  H03K19/1737 ,  H03K19/17704 ,  H03K19/17728 ,  H03K19/17736 ,  H03K19/1774 ,  H03K19/1776 ,  H03K19/1778 ,  H03K19/17792 ,  G01R31/318516

摘要： A programmable logic array integrated circuit has a number of programmable logic modules which are grouped together in a plurality of logic array blocks ("LABs") The LABs are arranged on the circuit in a two dimensional array. A conductor network is provided for interconnecting any logic module with any other logic module. In addition, adjacent or nearby logic modules are connectable to one another for such special purposes as providing a carry chain between logic modules and/or for connecting two or more modules together to provide more complex logic functions without having to make use of the general interconnection network. Another network of so-called fast or universal conductors is provided for distributing widely used logic signals such as clock and clear signals throughout the circuit. Multiplexers can be used in various ways to reduce the number of programmable interconnections required between signal conductors.

摘要翻译： 可编程逻辑阵列集成电路具有多个可编程逻辑模块，这些可编程逻辑模块在多个逻辑阵列块（“LAB”）中分组在一起.LAB以二维阵列布置在电路上。 提供一个导线网络，用于将任何逻辑模块与任何其他逻辑模块相互连接。 此外，相邻或附近的逻辑模块可以彼此连接，用于在逻辑模块之间提供进位链和/或用于将两个或多个模块连接在一起以提供更复杂的逻辑功能而不必利用一般互连的特殊目的 网络。 提供了所谓的快速或通用导体的另一网络，用于在整个电路中分布广泛使用的逻辑信号，例如时钟和清除信号。 多路复用器可以以各种方式用于减少信号导体之间所需的可编程互连数量。

公开(公告)号：US6028808A

公开(公告)日：2000-02-22

申请号：US851862

申请日：1997-05-06

申请人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. Mc Clintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

发明人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. Mc Clintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

IPC分类号： G01R31/3185 ,  G11C8/12 ,  H03K19/094 ,  H03K19/173 ,  H03K19/177 ,  A11C13/00

CPC分类号： H03K19/09429 ,  G11C8/12 ,  H03K19/1737 ,  H03K19/17704 ,  H03K19/17728 ,  H03K19/17736 ,  H03K19/1774 ,  H03K19/1776 ,  H03K19/1778 ,  H03K19/17792 ,  G01R31/318516

摘要： A programmable logic array integrated circuit has a number of programmable logic modules which are grouped together in a plurality of logic array blocks ("LABs"). The LABs are arranged on the circuit in a two dimensional array. A conductor network is provided for interconnecting any logic module with any other logic module. In addition, adjacent or nearby logic modules are connectable to one another for such special purposes as providing a carry chain between logic modules and/or for connecting two or more modules together to provide more complex logic functions without having to make use of the general interconnection network. Another network of so-called fast or universal conductors is provided for distributing widely used logic signals such as clock and clear signals throughout the circuit. Multiplexers can be used in various ways to reduce the number of programmable interconnections required between signal conductors.

公开(公告)号：US5848005A

公开(公告)日：1998-12-08

申请号：US851858

申请日：1997-05-06

申请人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. McClintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

发明人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. McClintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

IPC分类号： G01R31/3185 ,  G11C8/12 ,  H03K19/094 ,  H03K19/173 ,  H03K19/177 ,  G11C13/00

CPC分类号： H03K19/09429 ,  G11C8/12 ,  H03K19/1737 ,  H03K19/17704 ,  H03K19/17728 ,  H03K19/17736 ,  H03K19/1774 ,  H03K19/1776 ,  H03K19/1778 ,  H03K19/17792 ,  G01R31/318516

摘要： A programmable logic array integrated circuit has a number of programmable logic modules which are grouped together in a plurality of logic array blocks ("LABs"). The LABs are arranged on the circuit in a two dimensional array. A conductor network is provided for interconnecting any logic module with any other logic module. In addition, adjacent or nearby logic modules are connectable to one another for such special purposes as providing a carry chain between logic modules and/or for connecting two or more modules together to provide more complex logic functions without having to make use of the general interconnection network. Another network of so-called fast or universal conductors is provided for distributing widely used logic signals such as clock and clear signals throughout the circuit. Multiplexers can be used in various ways to reduce the number of programmable interconnections required between signal conductors.

公开(公告)号：US5812479A

公开(公告)日：1998-09-22

申请号：US851761

申请日：1997-05-06

申请人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. Mc Clintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

发明人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. Mc Clintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

IPC分类号： G01R31/3185 ,  G11C8/12 ,  H03K19/094 ,  H03K19/173 ,  H03K19/177 ,  G11C13/00

CPC分类号： H03K19/09429 ,  G11C8/12 ,  H03K19/1737 ,  H03K19/17704 ,  H03K19/17728 ,  H03K19/17736 ,  H03K19/1774 ,  H03K19/1776 ,  H03K19/1778 ,  H03K19/17792 ,  G01R31/318516

摘要： A programmable logic array integrated circuit has a number of programmable logic modules which are grouped together in a plurality of logic array blocks ("LABs"). The LABs are arranged on the circuit in a two dimensional array. A conductor network is provided for interconnecting any logic module with any other logic module. In addition, adjacent or nearby logic modules are connectable to one another for such special purposes as providing a carry chain between logic modules and/or for connecting two or more modules together to provide more complex logic functions without having to make use of the general interconnection network. Another network of so-called fast or universal conductors is provided for distributing widely used logic signals such as clock and clear signals throughout the circuit. Multiplexers can be used in various ways to reduce the number of programmable interconnections required between signal conductors.

公开(公告)号：US5550782A

公开(公告)日：1996-08-27

申请号：US245509

申请日：1994-05-18

申请人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. McClintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

发明人： Richard G. Cliff ,  L. Todd Cope ,  Cameron R. McClintock ,  William Leong ,  James A. Watson ,  Joseph Huang ,  Bahram Ahanin

IPC分类号： G01R31/3185 ,  G11C8/12 ,  H03K19/094 ,  H03K19/173 ,  H03K19/177 ,  G11C13/00

CPC分类号： H03K19/09429 ,  G11C8/12 ,  H03K19/1737 ,  H03K19/17704 ,  H03K19/17728 ,  H03K19/17736 ,  H03K19/1774 ,  H03K19/1776 ,  H03K19/1778 ,  H03K19/17792 ,  G01R31/318516

摘要： A programmable logic array integrated circuit has a number of programmable logic modules which are grouped together in a plurality of logic array blocks ("LABs"). The LABs are arranged on the circuit in a two dimensional array. A conductor network is provided for interconnecting any logic module with any other logic module. In addition, adjacent or nearby logic modules are connectable to one another for such special purposes as providing a carry chain between logic modules and/or for connecting two or more modules together to provide more complex logic functions without having to make use of the general interconnection network. Another network of so-called fast or universal conductors is provided for distributing widely used logic signals such as clock and clear signals throughout the circuit. Multiplexers can be used in various ways to reduce the number of programmable interconnections required between signal conductors.

公开(公告)号：US5486625A

公开(公告)日：1996-01-23

申请号：US272411

申请日：1994-07-08

申请人： William Leong ,  Lyman H. Smith

发明人： William Leong ,  Lyman H. Smith

IPC分类号： C07D405/06 ,  A01N43/50 ,  A01N43/653 ,  C07D405/14 ,  C07D407/04 ,  C07D521/00 ,  C07D317/00 ,  C07D233/04 ,  C07D249/08

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D407/04

摘要： Described is a process for preparing chiral compounds of the formula ##STR1## wherein X.sup.1 and X.sup.2 are independently F or Cl, and Y is Cl, Br or I, comprising reacting a triol of the formula ##STR2## wherein X.sup.1 and X.sup.2 are as defined above, with acetone in the presence of a catalyst, then with a halogen selected from Cl.sub.2, Br.sub.2 or I.sub.2, or N-bromosuccinimide or N-iodosuccinimide.

摘要翻译： 描述了制备式IMA的手性化合物的方法，其中X 1和X 2独立地是F或Cl，Y是Cl，Br或I，包括使下式的三醇：其中X 1和X 2如所定义 用丙酮在催化剂存在下，然后用选自Cl 2，Br 2或I 2的卤素或N-溴代琥珀酰亚胺或N-碘代琥珀酰亚胺。

公开(公告)号：US07521452B2

公开(公告)日：2009-04-21

申请号：US11326155

申请日：2006-01-05

申请人： Wenxue Wu ,  Loc Thanh Tran ,  Bosco D'Sa ,  Feng Liang ,  William Leong ,  Hong-Chang Lee ,  Kevin Klopfer ,  Vijay Sabesen

发明人： Wenxue Wu ,  Loc Thanh Tran ,  Bosco D'Sa ,  Feng Liang ,  William Leong ,  Hong-Chang Lee ,  Kevin Klopfer ,  Vijay Sabesen

IPC分类号： A61K31/497 ,  C07D239/02

CPC分类号： C07D401/14

摘要： The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.

摘要翻译： 本发明一般涉及通过创造性地选择酸和溶剂介质来直接制备相对于选择的碱性化合物的旋转异构酸盐富集的药学上可接受的盐的方法。 该方法在制备旋转异构体所需优势的药学上有用的盐的特定旋转异构体时特别有用。