Abstract:
In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function based at least in part on the classification data and the psychometric data is computationally derived, and one or more features of a query object are computationally classified based at least in part on the human-weighted loss function.
Abstract:
In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function based at least in part on the classification data and the psychometric data is computationally derived, and one or more features of a query object are computationally classifies based at least in part on the human-weighted loss function.
Abstract:
To promote ease of use, as well as a reduction in bit error rates during extended data exchange between a coupled NFC tag/reader pair, signal strength is measured from a plurality of NFC tag antennas each positioned differently with respect to a common reader field, and differences in signal strength are used to determine an optimum positioning of the tag, or tag emulator, with respect to the reader. Alternative embodiments may include signal time of flight for determining orientation of the NFC antennas within the reader field. Information is generated by the tag, or tag emulator, and output by the tag, or tag emulator, such that a user may direct the positioning of the tag, or tag emulator, for improved communication with the reader.
Abstract:
Microfluidic devices for manipulating relatively dense materials, such as colloidal rod particles, are provided. Microfluidic devices for separating a denser first material from a less-dense second material are provided. Methods of manipulating a relatively dense first material, for example, colloidal rod particles, and separating the first material from a less-dense second material, are provided. Methods of marking samples or sample components with relatively dense materials, are also provided.
Abstract:
There are disclosed methods for machining components, such as thermocouples 280 or SQUIDs 330, using ion beam milling. Ion beam milling is performed on a material 200 to expose a sliver 240. A sharp probe 161 is then attached to the sliver 240, for example by deposition of a tungsten weld 250. Further ion beam milling 261, 262, 263 is then performed to separate the sliver 240 from the material 200. The sliver 240 is then ion beam milled to produce the device 280, 330. In some embodiments, the thermocouple 280 is mounted to a substrate such as a silicon wafer having integrated signal conditioning circuitry. The invention allows small components (of the order of 1 μm) to be accurately manufactured without being constrained by typical lithographic constraints.
Abstract:
In various embodiments, training objects are classilied by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function based at least in part on the colassification data and the psychometric data is computationally derived, and one or more features of a query object are computationally classified based at least its part on the human-weighted loss function.
Abstract:
In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function based at least in part on the classification data and the psychometric data is computationally derived, and one or more features of a query object are computationally classified based at least in part on the human-weighted loss function.
Abstract:
Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 μl). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.
Abstract:
Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods.
Abstract:
The invention features methods for treating cancer in a patient in need thereof by administering eribulin, in combination with one or more PARP inhibitors, and, optionally, a platinum-based antineoplastic drug, and kits therefor. The invention is based in part on the observation that combinations of eribulin mesylate, a PARP inhibitor (e.g., E7449), and, optionally, a platinum-based antineo-plastic drug (e.g., carboplatin), show improved (e.g., synergistic) antitumor effects. Therefore, the present invention features methods of preventing and treating cancer (e.g., homologous recombination (HR)-deficient cancer by the use of combinations of eribulin (e.g., eribulin mesylate) and one or more PARP inhibitors (e.g., E7449 or a pharmaceutically acceptable salt thereof (e.g., the tartrate salt), optionally in combination with a platinum-based antineoplastic drug (e.g., carboplatin).