公开(公告)号：US20130281808A1

公开(公告)日：2013-10-24

申请号：US13451683

申请日：2012-04-20

Applicant: Dar-Bin SHIEH

Inventor： Dar-Bin SHIEH

IPC: A61B5/00

CPC classification number: A61B5/685 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/15019 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150801 ,  A61B5/150977 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15142 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B2560/0412

Abstract: The present invention relates to a blood component detection unit, which comprises: a capsule body having a first surface; a needle array including a plurality of needles, each of the needles have an opening and an inner hollow space, and each of the needles protrudes out of the first surface; a detection chamber disposed inside the capsule body and connected with the inner hollow space; a sensing chip disposed inside the capsule body; and a plurality of sensing elements disposed on the sensing chip.

Abstract translation: 血液成分检测装置技术领域本发明涉及一种血液成分检测装置，其特征在于，包括：胶囊主体， 包括多个针的针阵列，每个针具有开口和内部中空空间，并且每个针从第一表面突出; 检测室，其设置在所述胶囊主体的内部并与所述内部中空空间连接; 感测芯片，设置在所述胶囊主体内; 以及设置在感测芯片上的多个感测元件。

公开(公告)号：US20130070246A1

公开(公告)日：2013-03-21

申请号：US13613463

申请日：2012-09-13

Applicant: Dar-Bin SHIEH ,  Pau-Choo CHUNG

Inventor： Dar-Bin SHIEH ,  Pau-Choo CHUNG

IPC: G01J3/00

CPC classification number: G01N21/255 ,  A61B5/0075 ,  A61B5/6898 ,  A61B2560/0431 ,  A61B2562/046 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/10 ,  G01J3/2803 ,  G01N21/251 ,  G01N21/474 ,  G01N21/49 ,  G01N2021/4742 ,  G01N2201/067 ,  G01N2201/0833

Abstract: An optical detection apparatus used for detecting a tissue includes a light-emitting unit, a spectroscopic unit and a light-sensing array. The light-emitting unit emits light entering into the tissue. The spectroscopic unit receives the light outputted from the tissue and divides the received light into a plurality of rays with different wavelengths. The light-sensing array senses the rays outputted from the spectroscopic unit so as to generate an array spectrum. By the spectroscopic unit, the detection of the rays of multiple wavelengths can be performed without using plural light-emitting diodes for emitting light of different wavelengths. Besides, the user can perceive the detection result (e.g. the location of the abnormal tissue) intuitively by integrating the light-sensing array and the spectroscopic unit.

Abstract translation: 用于检测组织的光学检测装置包括发光单元，分光单元和光感测阵列。 发光单元发射进入组织的光。 分光单元接收从组织输出的光，并将接收的光分成具有不同波长的多个光线。 感光阵列感测从分光单元输出的光线，以产生阵列光谱。 通过分光单元，可以不使用多个用于发射不同波长的光的发光二极管来执行多个波长的光线的检测。 此外，通过集成光感测阵列和分光单元，用户可以直观地感知检测结果（例如异常组织的位置）。

公开(公告)号：US20130171258A1

公开(公告)日：2013-07-04

申请号：US13628306

申请日：2012-09-27

Applicant: Dar-Bin SHIEH ,  Hai-Wen CHEN ,  Chia-Chun CHEN ,  Ping-Ching WU

Inventor： Dar-Bin SHIEH ,  Hai-Wen CHEN ,  Chia-Chun CHEN ,  Ping-Ching WU

IPC: C12Q1/04

CPC classification number: C12N13/00 ,  C12Q1/04 ,  G01N33/574 ,  G01N33/57423 ,  G01N2800/52

Abstract: The present invention relates to a pharmaceutical composition for elevating radiation-sensitivity of cancer cells, which comprises: a nanoparticle containing with a first element, which is iron, copper, or the combination thereof; and a pharmaceutically acceptable carrier, wherein the nanoparticle is a metal nanoparticle, an alloy nanoparticle, or a metal nanoparticle with core-shell structure, and the size of the nanoparticle is under a controllable range of 3 nm to 150 nm. In addition, the present invention provides a detection method to detect radiation-sensitivity of the cancer cells through different modalities such as CT or MRI due to its native high CT number and magnetic property. Furthermore, the present invention provides a pharmaceutical composition for elevating radiation-sensitivity of the cancer cells through preferential uptake of the nanoparticle, in order to enhance the radiation-sensitivity of the cancer cells and improve the efficiency of radiation therapy to the cancer cells.

公开(公告)号：US20130071472A1

公开(公告)日：2013-03-21

申请号：US13624038

申请日：2012-09-21

Applicant: Dar-Bin SHIEH

Inventor： Dar-Bin SHIEH

IPC: A61K9/48 ,  A61K9/51 ,  A61K31/337

CPC classification number: A61K9/5192 ,  A61K9/5153 ,  A61K31/337 ,  B82Y5/00 ,  Y10S977/788 ,  Y10S977/915

Abstract: The present invention relates to a method for preparing a capsule nanoparticle used in encapsulating hydrophobic medicines, comprising the following steps: (A) providing a biocompatible polymer and an organic solution containing a hydrophobic medicine; (B) stirring the organic solution at 3-10° C., and titrating with an alcohol solution, so as to make the biocompatible polymer encapsulate hydrophobic medicine to form a capsule nanoparticle; (C) ultrasonic vibrating the capsule nanoparticle at 3-10° C.; (D) filtering the capsule nanoparticle to an average size controllable in the range of 60-450 nm; and (E) lyophilizing the encapsulated particles.

Abstract translation: 本发明涉及一种制备用于包封疏水性药物的胶囊型纳米颗粒的方法，包括以下步骤：（A）提供生物相容性聚合物和含有疏水性药物的有机溶液; （B）在3-10℃下搅拌有机溶液，用醇溶液滴定，以使生物相容性聚合物包封疏水药物以形成胶囊纳米颗粒; （C）超声振动胶囊纳米粒子3-10℃。 （D）将胶囊纳米颗粒过滤至60-450nm范围内可控的平均尺寸; 和（E）冻干包封的颗粒。

公开(公告)号：US20120209124A1

公开(公告)日：2012-08-16

申请号：US13354065

申请日：2012-01-19

Applicant: Dar-Bin SHIEH ,  Pau-Choo CHUNG ,  Yonhua TZENG

Inventor： Dar-Bin SHIEH ,  Pau-Choo CHUNG ,  Yonhua TZENG

IPC: A61B6/00

CPC classification number: A61B5/0091 ,  A61B2562/0233 ,  A61B2562/0242

Abstract: The present invention relates to a breast health care device, which comprises: a main body, which comprises at least one cover portion; and at least one node module, which is disposed on the cover portion. The node module comprises a light-emitting unit, a photo detector, or the combination thereof, wherein the light-emitting unit provides a light of predetermined wavelength to a breast tissue, and the photo detector detects a first signal generated from the breast tissue. Thus, users can directly achieve detection for the health condition of breasts by wearing the bra of the disclosed breast health care device of the present invention, and the disclosed health care device can transmit the detection results to an external health-care platform such as hospitals or medical centers immediately.

Abstract translation: 本发明涉及一种乳房保健装置，其包括：主体，其包括至少一个盖部; 以及设置在盖部上的至少一个节点模块。 节点模块包括发光单元，光电检测器或其组合，其中发光单元向乳房组织提供预定波长的光，并且光电检测器检测从乳房组织产生的第一信号。 因此，使用者可以通过佩戴本发明所公开的乳房保健装置的胸罩来直接实现对乳房健康状况的检测，并且所公开的保健装置可以将检测结果传送到诸如医院的外部保健平台 或医疗中心。

公开(公告)号：US20170202879A1

公开(公告)日：2017-07-20

申请号：US15326655

申请日：2015-07-17

Applicant: Dar-Bin SHIEH

Inventor： Dar-Bin SHIEH ,  Pei-Jane TSAI ,  Wei-Ting LEE ,  Tsung-Ju LI ,  Chen-Sheng YEH ,  Shang-Rung WU

IPC: A61K33/26 ,  A61K9/00 ,  A61K9/14

CPC classification number: A61K33/26 ,  A61K9/0019 ,  A61K9/14

Abstract: Disclosed herein is a use of Fe3-δO4 nanoparticle in inhibiting the spore germination of Clostridium difficile. The Fe3-δO4 nanoparticle specifically targets the spores of Clostridium difficile spores by damaging and breaking the intact structure of the Clostridium difficile spores. Further, the Fe3-δO4 nanoparticle possesses superior sporicidal activity, as compared to other known bactericidal nanoparticles. Therefore, the Fe3-δO4 nanoparticle of the disclosure is useful as a bactericide or more specifically, a sporicide to treat Clostridium difficile infection for its superior sporicidal activity.

公开(公告)号：US20130053660A1

公开(公告)日：2013-02-28

申请号：US13660066

申请日：2012-10-25

Applicant: Dar-Bin SHIEH

Inventor： Dar-Bin SHIEH

IPC: A61B5/157

CPC classification number: A61B5/157 ,  A61B5/150022 ,  A61B5/150106 ,  A61B5/150175 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150503 ,  A61B5/150847 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15142 ,  A61B5/15159 ,  A61B5/15163 ,  A61B5/15165 ,  A61B5/15171

Abstract: The present invention relates to a blood component detection unit, which comprises: a capsule body having a first surface; a needle array including a plurality of needles, each of the needles have an opening and an inner hollow space, and each of the needles protrudes out of the first surface; a detection chamber disposed inside the capsule body and connected with the inner hollow space; a sensing chip disposed inside the capsule body; and a plurality of sensing elements disposed on the sensing chip.

Abstract translation: 血液成分检测装置技术领域本发明涉及血液成分检测装置，其特征在于，包括：具有第一表面的胶囊主体; 包括多个针的针阵列，每个针具有开口和内部中空空间，并且每个针从第一表面突出; 检测室，其设置在所述胶囊主体的内部并与所述内部中空空间连接; 感测芯片，设置在所述胶囊主体内; 以及设置在感测芯片上的多个感测元件。