公开(公告)号：US20170202879A1

公开(公告)日：2017-07-20

申请号：US15326655

申请日：2015-07-17

Applicant: Dar-Bin SHIEH

Inventor： Dar-Bin SHIEH ,  Pei-Jane TSAI ,  Wei-Ting LEE ,  Tsung-Ju LI ,  Chen-Sheng YEH ,  Shang-Rung WU

IPC: A61K33/26 ,  A61K9/00 ,  A61K9/14

CPC classification number: A61K33/26 ,  A61K9/0019 ,  A61K9/14

Abstract: Disclosed herein is a use of Fe3-δO4 nanoparticle in inhibiting the spore germination of Clostridium difficile. The Fe3-δO4 nanoparticle specifically targets the spores of Clostridium difficile spores by damaging and breaking the intact structure of the Clostridium difficile spores. Further, the Fe3-δO4 nanoparticle possesses superior sporicidal activity, as compared to other known bactericidal nanoparticles. Therefore, the Fe3-δO4 nanoparticle of the disclosure is useful as a bactericide or more specifically, a sporicide to treat Clostridium difficile infection for its superior sporicidal activity.