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    BLOOD COMPONENT DETECTION DEVICE
    3.
    发明申请
    BLOOD COMPONENT DETECTION DEVICE 审中-公开
    血液成分检测装置

    公开(公告)号：US20130281808A1

    公开(公告)日：2013-10-24

    申请号：US13451683

    申请日：2012-04-20

    Applicant: Dar-Bin SHIEH

    Inventor： Dar-Bin SHIEH

    IPC: A61B5/00

    CPC classification number: A61B5/685 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/15019 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150801 ,  A61B5/150977 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15142 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B2560/0412

    Abstract: The present invention relates to a blood component detection unit, which comprises: a capsule body having a first surface; a needle array including a plurality of needles, each of the needles have an opening and an inner hollow space, and each of the needles protrudes out of the first surface; a detection chamber disposed inside the capsule body and connected with the inner hollow space; a sensing chip disposed inside the capsule body; and a plurality of sensing elements disposed on the sensing chip.

    Abstract translation: 血液成分检测装置技术领域本发明涉及一种血液成分检测装置，其特征在于，包括：胶囊主体， 包括多个针的针阵列，每个针具有开口和内部中空空间，并且每个针从第一表面突出; 检测室，其设置在所述胶囊主体的内部并与所述内部中空空间连接; 感测芯片，设置在所述胶囊主体内; 以及设置在感测芯片上的多个感测元件。

    Pharmaceutical composition for elevating radio-sensitivity of cancer cells, pharmaceutical composition for detecting cancer cells with radio-sensitivity, and detection method thereof
    4.
    发明授权
    Pharmaceutical composition for elevating radio-sensitivity of cancer cells, pharmaceutical composition for detecting cancer cells with radio-sensitivity, and detection method thereof 有权
    用于提高癌细胞的放射敏感性的药物组合物，用于检测具有放射敏感性的癌细胞的药物组合物及其检测方法

    公开(公告)号：US09121049B2

    公开(公告)日：2015-09-01

    申请号：US13628306

    申请日：2012-09-27

    Applicant: Dar-Bin Shieh ,  Hai-Wen Chen ,  Chia-Chun Chen ,  Ping-Ching Wu

    Inventor： Dar-Bin Shieh ,  Hai-Wen Chen ,  Chia-Chun Chen ,  Ping-Ching Wu

    IPC: G01N33/574 ,  C12Q1/04

    CPC classification number: C12N13/00 ,  C12Q1/04 ,  G01N33/574 ,  G01N33/57423 ,  G01N2800/52

    Abstract: The present invention relates to a pharmaceutical composition for elevating radiation-sensitivity of cancer cells, which comprises: a nanoparticle containing with a first element, which is iron, copper, or the combination thereof; and a pharmaceutically acceptable carrier, wherein the nanoparticle is a metal nanoparticle, an alloy nanoparticle, or a metal nanoparticle with core-shell structure, and the size of the nanoparticle is under a controllable range of 3 nm to 150 nm. In addition, the present invention provides a detection method to detect radiation-sensitivity of the cancer cells through different modalities such as CT or MRI due to its native high CT number and magnetic property. Furthermore, the present invention provides a pharmaceutical composition for elevating radiation-sensitivity of the cancer cells through preferential uptake of the nanoparticle, in order to enhance the radiation-sensitivity of the cancer cells and improve the efficiency of radiation therapy to the cancer cells.

    Abstract translation: 本发明涉及一种用于提高癌细胞的放射敏感性的药物组合物，其包含：含有第一元素的纳米颗粒，其为铁，铜或其组合; 和药学上可接受的载体，其中所述纳米颗粒是金属纳米颗粒，合金纳米颗粒或具有核 - 壳结构的金属纳米颗粒，并且所述纳米颗粒的尺寸在3nm至150nm的可控范围内。 此外，本发明提供了一种检测方法，由于其天然的高CT数和磁特性，通过CT或MRI等不同的方式检测癌细胞的放射敏感性。 此外，本发明提供了一种用于通过优先吸收纳米颗粒提高癌细胞的辐射敏感性的药物组合物，以增强癌细胞的辐射敏感性并提高对癌细胞的放射疗法的效率。

    COMPOSITION OF PI3K INHIBITOR AND USE THEREOF
    5.
    发明申请
    COMPOSITION OF PI3K INHIBITOR AND USE THEREOF 审中-公开
    PI3K抑制剂的组成及其用途

    公开(公告)号：US20140161891A1

    公开(公告)日：2014-06-12

    申请号：US13710026

    申请日：2012-12-10

    Applicant: WU-CHOU SU ,  DAR-BIN SHIEH ,  CHEN-SHENG YEH ,  CHIA-CHENG HOU

    Inventor： WU-CHOU SU ,  DAR-BIN SHIEH ,  CHEN-SHENG YEH ,  CHIA-CHENG HOU

    IPC: A61K9/50 ,  A61K31/5377

    CPC classification number: A61K31/5377 ,  A61K9/146 ,  A61K9/5153

    Abstract: The present invention is related to a composition of PI3K inhibitor, comprising: 0.01˜10 mg of PI3K inhibitor; 10˜500 mg of poly(lactic-co-glycolic acid) (PLGA) which is encapsulated onto the surface of the PI3K inhibitor and the surface is non-modified by a modifier; and the composition has a size of 10˜1000 nm. Thereby, an excellent effect on suppressing the growth of tumor cells will be achieved by the encapsulation of PI3K inhibitor into PLGA nanomaterials without any modifier on its surface, the optimization of a ratio of PI3K inhibitor to PLGA, and the accordingly slow release of the composition.

    Abstract translation: 本发明涉及PI3K抑制剂的组合物，其包含：0.01〜10mg PI3K抑制剂; 将10〜500mg封装在PI3K抑制剂表面上的聚（乳酸 - 共 - 乙醇酸）（PLGA）和表面未被改性剂修饰; 该组合物的尺寸为10〜1000nm。 因此，通过将PI3K抑制剂包被在PLGA纳米材料中，在其表面上没有任何改性剂，优化PI3K抑制剂与PLGA的比例以及相应的组合物缓慢释放，可以实现抑制肿瘤细胞生长的良好效果 。

    OPTICAL DETECTION APPARATUS
    7.
    发明申请
    OPTICAL DETECTION APPARATUS 审中-公开
    光学检测装置

    公开(公告)号：US20130070246A1

    公开(公告)日：2013-03-21

    申请号：US13613463

    申请日：2012-09-13

    Applicant: Dar-Bin SHIEH ,  Pau-Choo CHUNG

    Inventor： Dar-Bin SHIEH ,  Pau-Choo CHUNG

    IPC: G01J3/00

    CPC classification number: G01N21/255 ,  A61B5/0075 ,  A61B5/6898 ,  A61B2560/0431 ,  A61B2562/046 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/10 ,  G01J3/2803 ,  G01N21/251 ,  G01N21/474 ,  G01N21/49 ,  G01N2021/4742 ,  G01N2201/067 ,  G01N2201/0833

    Abstract: An optical detection apparatus used for detecting a tissue includes a light-emitting unit, a spectroscopic unit and a light-sensing array. The light-emitting unit emits light entering into the tissue. The spectroscopic unit receives the light outputted from the tissue and divides the received light into a plurality of rays with different wavelengths. The light-sensing array senses the rays outputted from the spectroscopic unit so as to generate an array spectrum. By the spectroscopic unit, the detection of the rays of multiple wavelengths can be performed without using plural light-emitting diodes for emitting light of different wavelengths. Besides, the user can perceive the detection result (e.g. the location of the abnormal tissue) intuitively by integrating the light-sensing array and the spectroscopic unit.

    Abstract translation: 用于检测组织的光学检测装置包括发光单元，分光单元和光感测阵列。 发光单元发射进入组织的光。 分光单元接收从组织输出的光，并将接收的光分成具有不同波长的多个光线。 感光阵列感测从分光单元输出的光线，以产生阵列光谱。 通过分光单元，可以不使用多个用于发射不同波长的光的发光二极管来执行多个波长的光线的检测。 此外，通过集成光感测阵列和分光单元，用户可以直观地感知检测结果（例如异常组织的位置）。

    PROBE COMPOSITE, METHOD FOR MANUFACTURING THE SAME, METHOD FOR USING THE SAME, AND CONTRAST AGENT INCLUDING THE SAME
    9.
    发明申请
    PROBE COMPOSITE, METHOD FOR MANUFACTURING THE SAME, METHOD FOR USING THE SAME, AND CONTRAST AGENT INCLUDING THE SAME 审中-公开
    探针组合物，其制造方法，使用它们的方法和包括其的对比剂

    公开(公告)号：US20110045607A1

    公开(公告)日：2011-02-24

    申请号：US12545093

    申请日：2009-08-21

    Applicant: Pai-Chi Li ,  Churng-Ren Wang ,  Dar-Bin Shieh ,  Chen-Wei Wei

    Inventor： Pai-Chi Li ,  Churng-Ren Wang ,  Dar-Bin Shieh ,  Chen-Wei Wei

    IPC: G01N33/553

    CPC classification number: B82Y30/00 ,  A61K49/00 ,  B82Y5/00

    Abstract: A probe composite for photoacoustic imaging includes a first probe and the second probe mixed with each other. The first probe includes a first ligand and a first nanorod conjugated to the first ligand. The first ligand specifically interacts with a first target. The second probe includes a second ligand and a second nanorod conjugated to the second ligand. The second ligand specifically interacts with a second target.

    Abstract translation: 用于光声成像的探针组合物包括彼此混合的第一探针和第二探针。 第一探针包括第一配体和与第一配体缀合的第一个纳米棒。 第一配体特异性地与第一靶标相互作用。 第二探针包括第二配体和与第二配体缀合的第二个纳米棒。 第二配体与第二靶特异性相互作用。

    Method for preparation of water-soluble and dispersed iron oxide nanoparticles and application thereof
    10.
    发明申请
    Method for preparation of water-soluble and dispersed iron oxide nanoparticles and application thereof 审中-公开
    水溶性和分散的氧化铁纳米颗粒的制备方法及其应用

    公开(公告)号：US20080299047A1

    公开(公告)日：2008-12-04

    申请号：US12081715

    申请日：2008-04-21

    Applicant: Chen-Sheng Yeh ,  Fong-Yu Cheng ,  Dar-Bin Shieh ,  Chao-Liang Wu

    Inventor： Chen-Sheng Yeh ,  Fong-Yu Cheng ,  Dar-Bin Shieh ,  Chao-Liang Wu

    IPC: C01G49/08 ,  A61K49/18

    CPC classification number: A61K49/1836 ,  B82Y5/00 ,  B82Y30/00 ,  C01G49/08 ,  C01P2004/04 ,  C01P2004/64

    Abstract: The present invention relates to a process for preparing water-soluble and dispersed iron oxide (Fe3O4) nanoparticles and application thereof, characterized in which two-stage additions of protective agent and chemical co-precipitation are employed in the process. In the first stage, Fe3O4 nanoparticles are obtained using absorbent-reactant coexistence technology. In the second stage, proper amount of adherent is added to cover the nanoparticle surface entirely. The resulting water-soluble and dispersed Fe3O4 nanoparticles can easily bind with thiols or biomolecules, such as nucleic acid and peptide. The Fe3O4 nanoparticles of the present invention may be used as magnetic resonance imaging contrast agent and used in magnetic guiding related biomolecular technologies for clinical testing, diagnosis and treatment.

    Abstract translation: 本发明涉及一种制备水溶性和分散的氧化铁（Fe 3 O 4）纳米颗粒的方法及其应用，其特征在于在该过程中采用两步添加保护剂和化学共沉淀。 在第一阶段，使用吸收剂 - 反应物共存技术获得Fe3O4纳米颗粒。 在第二阶段，添加适量的粘附剂以完全覆盖纳米颗粒表面。 所得到的水溶性和分散的Fe 3 O 4纳米颗粒可以容易地与硫醇或生物分子如核酸和肽结合。 本发明的Fe 3 O 4纳米颗粒可用作磁共振成像造影剂，用于磁导相关的生物分子技术用于临床测试，诊断和治疗。

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