公开(公告)号：US08195282B2

公开(公告)日：2012-06-05

申请号：US11743027

申请日：2007-05-01

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/04 ,  A61B5/05 ,  A61B10/00 ,  A61B5/103 ,  A61B5/117 ,  A61B17/00 ,  A61B18/18

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。

公开(公告)号：US20120123244A1

公开(公告)日：2012-05-17

申请号：US13337183

申请日：2011-12-26

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B6/00 ,  A61B5/053 ,  A61B5/055 ,  A61B5/01 ,  A61B5/103 ,  A61B8/00

CPC classification number: A61B6/032 ,  A61B5/0059 ,  A61B5/015 ,  A61B5/0536 ,  A61B5/055 ,  A61B5/103 ,  A61B5/4312 ,  A61B5/6834 ,  A61B5/6843 ,  A61B5/6844 ,  A61B5/6885 ,  A61B5/6886 ,  A61B6/4417 ,  A61B6/5247 ,  A61B8/13

Abstract: The present invention relates to a device for tissue-characterization, designed for effective sensor-to-tissue contact. The device includes an element, having a rigid surface of a linear cross-section, on which at least one sensor is arranged, and a mechanism for applying a force to a soft tissue, the line of force being at an acute angle with the rigid surface, for stretching or stretching and pushing the soft tissue against the rigid surface, thus achieving effective contact between the tissue and the at least one sensor. In consequence, the accuracy of the sensing is improved. In accordance with another embodiment, a plurality of sensors is employed, arranged along a curved element, for providing three-dimensional information regarding the tissue, for example, by small-scale computerized tomography.

Abstract translation: 本发明涉及一种用于组织表征的设备，用于有效的传感器与组织接触。 该装置包括具有线性横截面的刚性表面的元件，至少一个传感器布置在该元件上，以及用于向软组织施加力的机构，该力与刚性线成锐角 表面，用于拉伸或拉伸并将软组织推靠在刚性表面上，从而实现组织与至少一个传感器之间的有效接触。 因此，传感的精度得到改善。 根据另一个实施例，采用多个传感器，沿弯曲元件布置，用于提供关于组织的三维信息，例如通过小规模计算机断层摄影。

公开(公告)号：US08019411B2

公开(公告)日：2011-09-13

申请号：US11705143

申请日：2007-02-12

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05

CPC classification number: A61B5/053 ,  A61B5/415 ,  A61B5/418

Abstract: The present invention relates to probes, systems, and methods for tissue characterization by its dielectric properties, wherein a physical feature of the probe is designed to define and delimit a tissue volume, at a tissue edge, where characterization takes place. Thus, the probe for tissue-edge characterization comprises: a first inner conductor, which comprises: proximal and distal ends, with respect to a tissue edge, along an x-axis; a first sharp edge, inherently associated with the proximal end; at least one feature, issuing from the first inner conductor, substantially at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a generally predefined tissue volume, at the tissue edge, the tissue volume being generally defined by physical parameters associated with the at least one feature; and a dielectric material, which encloses the conductor, in the y-z planes.

Abstract translation: 本发明涉及用于通过其介电特性进行组织表征的探针，系统和方法，其中探针的物理特征被设计成在组织边缘处限定和限定组织体积，其中进行表征。 因此，用于组织边缘表征的探针包括：第一内部导体，其包括：沿x轴的相对于组织边缘的近端和远端; 固有地与近端相关联的第一锋利边缘; 至少一个特征，从第一内部导体发出，基本上在近端处，用于形成至少一个额外的锋利边缘，用于在组织边缘处的通常预定的组织体积内增强组织中的局部电气条纹区域， 组织体积通常由与至少一个特征相关联的物理参数限定; 以及在y-z平面中包围导体的电介质材料。

公开(公告)号：US07899515B2

公开(公告)日：2011-03-01

申请号：US11887571

申请日：2006-03-29

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05

CPC classification number: A61B5/05 ,  G01R27/2664

Abstract: A sensor for tissue characterization is provided, comprising: a resonator, configured to be placed proximally to an edge of a tissue for characterization, without penetrating the tissue, the resonator comprising a conductive structure associated with a diameter-equivalent dimension D, in a plane substantially parallel with the edge, and with a feature size d; and at least one conductive lead, for providing communication with an external system, wherein the resonator is configured to resonate at a frequency which corresponds to a free-air wavelength range of between about lambda and about 40 lambda, wherein lambda is at least about ten times the diameter-equivalent D, and wherein upon receiving a signal in the range of between about lambda and about 40 lambda, the sensor is configured to induce electric and magnetic fields, in a near zone, in the tissue, the near zone having a diameter of about D, so that the tissue in the near zone effectively functions as part of the resonator, influencing its resonating values, and so the tissue in the near zone is thereby characterized by its electromagnetic properties, by the resonating response of the resonator.

Abstract translation: 提供了一种用于组织表征的传感器，包括：谐振器，被配置为被放置在组织的边缘的近侧，用于表征，而不穿透组织，所述谐振器包括与直径等效尺寸D相关联的导电结构 基本上与边缘平行，具有特征尺寸d; 以及用于提供与外部系统的通信的至少一个导电引线，其中所述谐振器被配置为以对应于约λ至约40λ之间的自由空气波长范围的频率谐振，其中λ为至少约十 倍，直径等效D，并且其中当接收到在约λλ和约40λ之间的范围内的信号时，所述传感器被配置为在所述组织中的近区域中诱导电场和磁场，所述近区具有 大约D的直径，使得近区域中的组织有效地用作谐振器的一部分，影响其谐振值，因此通过谐振器的谐振响应，近区域中的组织的特征在于其电磁特性。

公开(公告)号：US20090062637A1

公开(公告)日：2009-03-05

申请号：US11887571

申请日：2006-03-29

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05

CPC classification number: A61B5/05 ,  G01R27/2664

Abstract: A sensor for tissue characterization is provided, comprising: a resonator, configured to be placed proximally to an edge of a tissue for characterization, without penetrating the tissue, the resonator comprising a conductive structure associated with a diameter-equivalent dimension D, in a plane substantially parallel with the edge, and with a feature size d; and at least one conductive lead, for providing communication with an external system, wherein the resonator is configured to resonate at a frequency which corresponds to a free-air wavelength range of between about lambda and about 40 lambda, wherein lambda is at least about ten times the diameter-equivalent D, and wherein upon receiving a signal in the range of between about lambda and about 40 lambda, the sensor is configured to induce electric and magnetic fields, in a near zone, in the tissue, the near zone having a diameter of about D, so that the tissue in the near zone effectively functions as part of the resonator, influencing its resonating values, and so the tissue in the near zone is thereby characterized by its electromagnetic properties, by the resonating response of the resonator.

Abstract translation: 提供了一种用于组织表征的传感器，包括：谐振器，被配置为被放置在组织的边缘的近侧，用于表征，而不穿透组织，所述谐振器包括与直径等效尺寸D相关联的导电结构 基本上与边缘平行，具有特征尺寸d; 以及用于提供与外部系统的通信的至少一个导电引线，其中所述谐振器被配置为以对应于约λ至约40λ之间的自由空气波长范围的频率谐振，其中λ为至少约十 倍，直径等效D，并且其中当接收到在约λλ和约40λ之间的范围内的信号时，所述传感器被配置为在所述组织中的近区域中诱导电场和磁场，所述近区具有 大约D的直径，使得近区域中的组织有效地用作谐振器的一部分，影响其谐振值，因此通过谐振器的谐振响应，近区域中的组织的特征在于其电磁特性。

公开(公告)号：US07184824B2

公开(公告)日：2007-02-27

申请号：US10965752

申请日：2004-10-18

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/05

CPC classification number: A61B5/415 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/418

Abstract: A probe, method and system for examining tissue in order to differentiate it from other tissue according to the dielectric properties of the examined tissue are provided. The probe includes an inner conductor, having a plurality of sharp, thin, conductive spikes, at a proximal end with respect to a tissue for examination, the plurality of sharp, thin, conductive spikes being operative to enhance the electrical fringe fields, where interaction with the tissue for examination occurs. The method includes: applying the probe to the tissue to be examined, such that the probe generates an electrical fringe field in the zone of the examined tissue and produces a reflected pulse therefrom with negligible radiation penetrating into the tissue itself; detecting the reflected electrical pulse; and comparing electrical characteristics of the reflected electrical pulse with respect to the applied electrical pulse to provide an indication of the dielectric properties of the examined tissue.

Abstract translation: 提供了用于检查组织以便根据被检查组织的介电性质将其与其他组织区分开的探针，方法和系统。 所述探针包括内导体，所述内导体具有相对于组织进行检查的近端处的多个尖锐，薄的导电尖峰，所述多个尖锐的，薄的导电尖钉可操作以增强电边缘场，其中相互作用 随着组织进行检查。 该方法包括：将探针施加到待检查的组织，使得探针在被检查组织的区域中产生电气边缘场，并从其中产生可忽略的辐射穿透到组织本身中的反射脉冲; 检测反射电脉冲; 并且将反射电脉冲的电特性相对于所施加的电脉冲进行比较，以提供被检查组织的介电性质的指示。

公开(公告)号：US07720532B2

公开(公告)日：2010-05-18

申请号：US10558831

申请日：2005-03-23

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05 ,  A61B8/00 ,  A61B5/103 ,  A61B5/117 ,  A61B17/00

CPC classification number: A61B5/415 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/01 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/055 ,  A61B5/06 ,  A61B5/4312 ,  A61B8/0858 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4472 ,  A61B18/082 ,  A61B34/20 ,  A61B2017/00026 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/061 ,  A61B2090/367 ,  A61B2090/378

Abstract: An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

Abstract translation: 提供了一种集成工具，具有用于确定组织表面的近区域体积处的组织类型的组织型传感器和用于确定与另一组织类型的界面的距离的距离测量传感器，用于（i ）确认正在被去除的恶性肿瘤周围存在健康组织的清洁边缘，以及（ii）确定清洁边缘的深度。 集成工具还可以包括位置跟踪装置和切口装置。 当肿瘤被移除时，软组织可以保持在固定框架内。 另外，提供了一种用于恶性肿瘤去除的方法，包括：将软组织固定在框架内，利用手持式集成工具从软组织周围的多个位置和取向进行成像，重建三维图像 软组织和肿瘤内，在重建图像上限定所需的清洁边缘，计算推荐切口路径，在重建图像上显示推荐路径，以及在确定其类型的同时切割组织，在切口的近区体积处 表面。 该方法可以进一步包括连续成像切割，连续校正重建图像和推荐切口路径，以及在切口表面的近区域体积处连续地确定组织类型。

公开(公告)号：US07505811B2

公开(公告)日：2009-03-17

申请号：US10298196

申请日：2002-11-18

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/05 ,  A61B6/00

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.

Abstract translation: 一种用于通过使检查组织对包含与选择性地与靶细胞结合的生物载体结合的物理元素的小颗粒的造影剂来检查组织是否存在靶细胞特别是癌细胞的方法，装置和探针。 能量脉冲被施加到被检查的组织。 检测由所施加的能量脉冲产生的被检查组织的阻抗和/或光学特性的变化并用于确定所检查组织中靶细胞的存在。 在所描述的优选实施例中，所施加的能量脉冲包括激光脉冲，并且与生物载体共轭的物理元件是具有在存在光时显着降低的阻抗的光敏半导体。 用于检测靶细胞的相同探针也可用于破坏如此靶向的细胞。

公开(公告)号：US20080249434A1

公开(公告)日：2008-10-09

申请号：US10582135

申请日：2006-03-02

Applicant: Dan Hashimshony ,  Orit Yarden ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Orit Yarden ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

IPC: A61B10/02 ,  C12M1/00

CPC classification number: A61B10/0096 ,  A01N1/02 ,  A01N1/0273 ,  A61B90/39 ,  A61B2017/320064 ,  A61B2090/0807 ,  A61B2090/0811 ,  A61B2090/3908 ,  B01L3/508 ,  G01N1/312

Abstract: A device and method and provided for tissue handling, while maintaining the in-vivo tissue orientation. The device includes a structure, configured for receiving and holding a tissue specimen, wherein the tissue specimen includes tissue positional references; and device positional references, associated with the structure, for fixing the orientation of the tissue specimen, when held by the device, so as to reflect the tissue specimen positional references.

Abstract translation: 一种装置和方法，并提供用于组织处理，同时保持体内组织取向。 所述装置包括构造成用于接收和保持组织样本的结构，其中所述组织样本包括组织位置参考; 以及与所述结构相关联的用于固定所述组织样本的取向的装置位置参考，当被所述装置保持时，以便反映所述组织样本位置参考。

公开(公告)号：US20080039742A1

公开(公告)日：2008-02-14

申请号：US11745334

申请日：2007-05-07

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/103

CPC classification number: A61B5/415 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/01 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/055 ,  A61B5/06 ,  A61B5/068 ,  A61B5/4312 ,  A61B8/0858 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4472 ,  A61B34/20 ,  A61B34/30 ,  A61B2017/00026 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2017/00106 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/061 ,  A61B2090/367 ,  Y10S607/901

Abstract: An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

Abstract translation: 提供了一种集成工具，具有用于确定组织表面的近区域体积处的组织类型的组织型传感器和用于确定与另一组织类型的界面的距离的距离测量传感器，用于（i ）确认正在被去除的恶性肿瘤周围存在健康组织的清洁边缘，以及（ii）确定清洁边缘的深度。 集成工具还可以包括位置跟踪装置和切口装置。 当肿瘤被移除时，软组织可以保持在固定框架内。 另外，提供了一种用于恶性肿瘤去除的方法，包括：将软组织固定在框架内，利用手持式集成工具从软组织周围的多个位置和取向进行成像，重建三维图像 软组织和肿瘤内，在重建图像上限定所需的清洁边缘，计算推荐切口路径，在重建图像上显示推荐路径，以及在确定其类型的同时切割组织，在切口的近区体积处 表面。 该方法可以进一步包括连续成像切割，连续校正重建图像和推荐切口路径，以及在切口表面的近区域体积处连续地确定组织类型。