公开(公告)号：US20130220176A1

公开(公告)日：2013-08-29

申请号：US13881762

申请日：2011-11-07

申请人： Daisuke Asanuma ,  Tomoya Hidaka

发明人： Daisuke Asanuma ,  Tomoya Hidaka

IPC分类号： C09D7/14

CPC分类号： C09D7/14 ,  C08G77/045 ,  C08G77/08 ,  C08G77/34 ,  C09D7/80 ,  C09D183/04

摘要： A solid material or an oily material for forming an organic thin film is produced by hydrolyzing and condensing at least one kind of organic metal compound expressed by Formula (1) in a lower alcohol-based solvent in the presence of water and an acid with a concentration of 0.5% to 5% by mass in the resultant reaction solution. The solid material or oily material that is obtained is dissolved in an organic solvent, and a substrate is brought into contact with a solution that is obtained to form a highly functional organic thin film on the substrate. [Chemical Formula 1] R1nMXm−n  (I)

摘要翻译： 用于形成有机薄膜的固体材料或油性材料通过在水和酸的存在下将低级醇类溶剂中的至少一种式（1）表示的有机金属化合物水解和缩合而制备有机薄膜， 在所得反应溶液中浓度为0.5〜5质量％。 将得到的固体物质或油性物质溶解在有机溶剂中，使基板与在基板上形成高功能性有机薄膜而获得的溶液接触。 [化学式1] R1nMXm-n（I）

公开(公告)号：US09309416B2

公开(公告)日：2016-04-12

申请号：US13881762

申请日：2011-11-07

申请人： Daisuke Asanuma ,  Tomoya Hidaka

发明人： Daisuke Asanuma ,  Tomoya Hidaka

IPC分类号： C09D7/14 ,  C08G77/34 ,  C09D183/04 ,  C08G77/04 ,  C08G77/08

CPC分类号： C09D7/14 ,  C08G77/045 ,  C08G77/08 ,  C08G77/34 ,  C09D7/80 ,  C09D183/04

摘要： A solid material or an oily material for forming an organic thin film is produced by hydrolyzing and condensing at least one kind of organic metal compound expressed by Formula (1) in a lower alcohol-based solvent in the presence of water and an acid with a concentration of 0.5% to 5% by mass, or in a solvent that contains at least an aliphatic ether based or aliphatic ketone based solvent and an acid content of 0.1 to 20 moles acid per mole of the organic metal compound, in the resultant reaction solution. The solid material or oily material that is obtained is dissolved in an organic solvent, and a substrate is brought into contact with a solution that is obtained to form a highly functional organic thin film on the substrate.[Chemical Formula 1] R1nMXm−n  (I)

摘要翻译： 用于形成有机薄膜的固体材料或油性材料通过在水和酸的存在下将低级醇类溶剂中的至少一种式（1）表示的有机金属化合物水解和缩合而制备有机薄膜， 或在含有至少一种脂族醚类或脂肪族酮类溶剂的溶剂中，并且每摩尔有机金属化合物的酸含量为0.1-20摩尔酸的所得反应溶液中的浓度为0.5质量％至5质量％ 。 将得到的固体物质或油性物质溶解在有机溶剂中，使基板与在基板上形成高功能性有机薄膜而获得的溶液接触。 [化学式1] R1nMXm-n（I）

公开(公告)号：US09784732B2

公开(公告)日：2017-10-10

申请号：US14343033

申请日：2012-09-06

申请人： Yasuteru Urano ,  Tetsuo Nagano ,  Daisuke Asanuma ,  Kenzo Hirose ,  Shigeyuki Namiki ,  Yousuke Takaoka

发明人： Yasuteru Urano ,  Tetsuo Nagano ,  Daisuke Asanuma ,  Kenzo Hirose ,  Shigeyuki Namiki ,  Yousuke Takaoka

IPC分类号： C07D311/82 ,  C07D405/10 ,  C07D405/14 ,  G01N33/52 ,  C09K11/06 ,  C07D405/04 ,  C09B11/24 ,  G01N33/50 ,  C09B69/00 ,  C09B69/10 ,  G01N21/64

CPC分类号： G01N33/52 ,  C07D311/82 ,  C07D405/04 ,  C07D405/14 ,  C09B11/24 ,  C09B69/00 ,  C09B69/103 ,  C09K11/06 ,  C09K2211/1044 ,  C09K2211/1088 ,  G01N21/6428 ,  G01N33/5005

摘要： Provided is a compound represented by formula (I), which can be used as a fluorescent probe that becomes highly fluorescent only in an intracellular acidic environment and can be adapted to the fluorescent imaging of an intracellular vesicle that is a microstructure. In the formula, R1 and R2 independently represent a hydrogen atom, or an alkyl group which may be substituted (wherein R1 and/or R2 represents an alkyl group which may be substituted); R3, R4, R5, R6, R7 and R8 independently represent a hydrogen atom, a halogen atom, or the like; X represents a functional group to which a labeling site or a target-accumulating site can be introduced, or the like; Y represents a halogen atom, an alkyl group which may be substituted, or the like; m represents an integer of 0 to 5; and n represents an integer of 0 to 5.

公开(公告)号：US20100068733A1

公开(公告)日：2010-03-18

申请号：US12447723

申请日：2007-11-15

申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Daisuke Asanuma

发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Daisuke Asanuma

IPC分类号： G01N33/53 ,  C07F5/02

CPC分类号： C07F5/022 ,  G01N21/80

摘要： A compound represented by the following general formula (I): wherein R1 represents an amino group which may be substituted with one or two alkyl groups; R2, R3, R4 and R5 independently represent an alkyl group; and R6 and R7 independently represent a monocarboxyalkyl group, a salt thereof, or an ester thereof, which is useful as a pH-sensitive fluorescent probe which emits intense fluorescence in an acidic region.

摘要翻译： 由以下通式（I）表示的化合物：其中R1表示可被一个或两个烷基取代的氨基; R2，R3，R4和R5独立地表示烷基; 并且R6和R7独立地表示单羧基烷基，其盐或其酯，其可用作在酸性区域发射强荧光的pH敏感荧光探针。

公开(公告)号：US07358356B2

公开(公告)日：2008-04-15

申请号：US10529392

申请日：2003-10-02

申请人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

发明人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

IPC分类号： C07D499/18

CPC分类号： C07D499/893 ,  C07D499/88

摘要： The present invention provides a method for preparing an organic compound, which comprises a dehydration step of distilling off water from a polar organic solvent solution containing the organic compound and water to bring the concentration of water below a given level, wherein the dehydration step comprises distilling off water together with the polar organic solvent while adding a polar organic solvent to the solution, or comprises repeating several cycles of adding a polar organic solvent to the solution and then distilling off water together with the polar organic solvent. The present invention further provides the preparation of an organic compound, which enables efficient isolation of the target product in high isolated yield from a polar organic solvent solution containing the organic compound, water and, if necessary, a compound which produces, upon coming into contact with water or the like, a substance accelerating the decomposition of the organic compound.

摘要翻译： 本发明提供了一种制备有机化合物的方法，该方法包括从含有有机化合物和水的极性有机溶剂溶液中蒸馏出水以使水的浓度低于给定水平的脱水步骤，其中脱水步骤包括蒸馏 将极性有机溶剂与极性有机溶剂一起加入到溶液中，或者包括重复多次向溶液中加入极性有机溶剂，然后与极性有机溶剂一起蒸馏出水。 本发明还提供有机化合物的制备，其能够以高分离产率从含有有机化合物的极性有机溶剂溶液，水和必要时的化合物在接触时产生高分离产物。 用水等加速有机化合物分解的物质。

公开(公告)号：US08258171B2

公开(公告)日：2012-09-04

申请号：US12447723

申请日：2007-11-15

申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Daisuke Asanuma

发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Daisuke Asanuma

IPC分类号： A61K31/40 ,  C07D209/56

CPC分类号： C07F5/022 ,  G01N21/80

摘要： A compound represented by the following general formula (I): wherein R1 represents an amino group which may be substituted with one or two alkyl groups; R2, R3, R4 and R5 independently represent an alkyl group; and R6 and R7 independently represent a monocarboxyalkyl group, a salt thereof, or an ester thereof, which is useful as a pH-sensitive fluorescent probe which emits intense fluorescence in an acidic region.

摘要翻译： 由以下通式（I）表示的化合物：其中R1表示可被一个或两个烷基取代的氨基; R2，R3，R4和R5独立地表示烷基; 并且R6和R7独立地表示单羧基烷基，其盐或其酯，其可用作在酸性区域发射强荧光的pH敏感荧光探针。

公开(公告)号：US20140248654A1

公开(公告)日：2014-09-04

申请号：US14343033

申请日：2012-09-06

申请人： Yasuteru Urano ,  Tetsuo Nagano ,  Daisuke Asanuma ,  Kenzo Hirose ,  Shigeyuki Namiki ,  Yousuke Takaoka

发明人： Yasuteru Urano ,  Tetsuo Nagano ,  Daisuke Asanuma ,  Kenzo Hirose ,  Shigeyuki Namiki ,  Yousuke Takaoka

IPC分类号： G01N33/52

CPC分类号： G01N33/52 ,  C07D311/82 ,  C07D405/04 ,  C07D405/14 ,  C09B11/24 ,  C09B69/00 ,  C09B69/103 ,  C09K11/06 ,  C09K2211/1044 ,  C09K2211/1088 ,  G01N21/6428 ,  G01N33/5005

摘要： Provided is a compound represented by formula (I), which can be used as a fluorescent probe that becomes highly fluorescent only in an intracellular acidic environment and can be adapted to the fluorescent imaging of an intracellular vesicle that is a microstructure. In the formula, R1 and R2 independently represent a hydrogen atom, or an alkyl group which may be substituted (wherein R1 and/or R2 represents an alkyl group which may be substituted); R3, R4, R5, R6, R7 and R8 independently represent a hydrogen atom, a halogen atom, or the like; X represents a functional group to which a labeling site or a target-accumulating site can be introduced, or the like; Y represents a halogen atom, an alkyl group which may be substituted, or the like; m represents an integer of 0 to 5; and n represents an integer of 0 to 5.

摘要翻译： 提供由式（I）表示的化合物，其可以用作仅在细胞内酸性环境中变得高度荧光的荧光探针，并且可以适用于作为微结构的细胞内小泡的荧光成像。 在该式中，R 1和R 2独立地表示氢原子或可被取代的烷基（其中R 1和/或R 2表示可被取代的烷基）; R 3，R 4，R 5，R 6，R 7和R 8独立地表示氢原子，卤素原子等; X表示可以引入标记位点或靶标积累位点的官能团等; Y表示卤原子，可被取代的烷基等; m表示0〜5的整数， n表示0〜5的整数。

公开(公告)号：US20060058521A1

公开(公告)日：2006-03-16

申请号：US10529392

申请日：2003-10-02

申请人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

发明人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

IPC分类号： C07D205/02

CPC分类号： C07D499/893 ,  C07D499/88

摘要： The present invention provides a method for preparing an organic compound, which comprises a dehydration step of distilling off water from a polar organic solvent solution containing the organic compound and water to bring the concentration of water below a given level, wherein the dehydration step comprises distilling off water together with the polar organic solvent while adding a polar organic solvent to the solution, or comprises repeating several cycles of adding a polar organic solvent to the solution and then distilling off water together with the polar organic solvent. The present invention further provides the preparation of an organic compound, which enables efficient isolation of the target product in high isolated yield from a polar organic solvent solution containing the organic compound, water and, if necessary, a compound which produces, upon coming into contact with water or the like, a substance accelerating the decomposition of the organic compound.

摘要翻译： 本发明提供了一种制备有机化合物的方法，该方法包括从含有有机化合物和水的极性有机溶剂溶液中蒸馏出水以使水的浓度低于给定水平的脱水步骤，其中脱水步骤包括蒸馏 将极性有机溶剂与极性有机溶剂一起加入到溶液中，或者包括重复多次向溶液中加入极性有机溶剂，然后与极性有机溶剂一起蒸馏出水。 本发明还提供有机化合物的制备，其能够以高分离产率从含有有机化合物的极性有机溶剂溶液，水和必要时的化合物在接触时产生高分离产物。 用水等加速有机化合物分解的物质。