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公开(公告)号：US20230236201A1
公开(公告)日：2023-07-27
申请号：US17999621
申请日：2021-05-20
发明人： Thomas R. COVEY , Chang LIU
IPC分类号： G01N33/68 , G01N33/543 , G01N27/624 , G01N27/74
CPC分类号： G01N33/6851 , G01N33/54326 , G01N27/624 , G01N27/745
摘要： In a system for affinity selection by mass spectrometry, wherein a plurality of drug candidates in solution are separated based on affinity, a method is provided comprising introducing a solid-phase device having binding affinity for a selected protein into the solution, binding at least one of the plurality of drug candidates to the solid-phase device as a selected drug candidate, washing the solid-phase device and selected drug candidate to separate unbound material, sampling the selected drug candidate in capture fluid flowing through a sampling region of an open port sampling interface and directing the sampled selected drug candidate and capture fluid to an ionization source.
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公开(公告)号：US20240170271A1
公开(公告)日：2024-05-23
申请号：US18552685
申请日：2022-03-30
CPC分类号： H01J49/0404 , H01J49/0431 , H01J49/145 , H01J49/165
摘要： A method of analyzing a liquid with a mass analysis device having a bubble generating interface (BGI) and a removal conduit includes aspirating a sample into the removal conduit at an aspira-tion pressure. Concurrently with aspirating the sample at least one operational condition of the BGI is controlled to generate a plurality of bubbles in the sample. Concurrently with aspirating the sample the plurality of bubbles are aspirated into the removal conduit. The sample and the plurality of bubbles are analyzed with the mass analysis device to generate a signal.
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公开(公告)号：US20240170270A1
公开(公告)日：2024-05-23
申请号：US18550016
申请日：2022-03-22
CPC分类号： H01J49/0404 , H01J49/0431 , H01J49/165
摘要： A method of evacuating a liquid sample from an open port interface (OPI) via a pressure drop includes applying the pressure drop to a transport liquid. This application generates a plurality of bubbles in the transport liquid during evacuation of the transport liquid from the OPI via a transfer conduit. The liquid sample is separated from a subsequent liquid sample by at least one of the generated bubbles.
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公开(公告)号：US20240085373A1
公开(公告)日：2024-03-14
申请号：US18262972
申请日：2022-02-23
IPC分类号： G01N27/624 , G01N27/623 , H01J49/00 , H01J49/16
CPC分类号： G01N27/624 , G01N27/623 , H01J49/0031 , H01J49/165
摘要： A method of operating a differential mobility spectrometer (DMS) includes providing a heater disposed proximate a ceramic body of a DMS cell. A first control voltage is applied to the heater. A first threshold is detected by a first sensor disposed within a curtain plate that substantially surrounds the DMS cell. A second control voltage is applied to the heater based at least in part on the detected first threshold. During application of the second control voltage, a mass spectrometry analysis of a gas within the DMS cell is performed.
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公开(公告)号：US20240203717A1
公开(公告)日：2024-06-20
申请号：US18286160
申请日：2022-04-07
发明人： Thomas R. COVEY , Chang LIU
IPC分类号： H01J49/04
CPC分类号： H01J49/0445 , H01J49/0409 , H01J49/0454
摘要： In one aspect, a method of extracting a target analyte from a sample for introduction into a mass spectrometer is disclosed, which includes mixing the sample with a paramagnetic medium to form a mixture, subjecting the mixture to a magnetic field gradient to form a non-homogenous distribution of at least one of the analyte and at least one interfering component of the sample, if any, thereby enhancing a concentration of the target analyte within a spatial location of said mixture, extracting at least a portion of the target analyte from that spatial location, and introducing at least a portion of the extracted target analyte into said mass spectrometer.
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公开(公告)号：US20240177987A1
公开(公告)日：2024-05-30
申请号：US18282841
申请日：2021-11-18
IPC分类号： H01J49/42 , G01N33/02 , G01N33/483 , H01J49/24
CPC分类号： H01J49/4215 , G01N33/02 , G01N33/4833 , H01J49/24
摘要： In one aspect, a method of performing mass spectrometric analysis of a sample, e.g. a food-based sample, is disclosed, which comprises ionizing the sample to generate a plurality of ions, introducing the plurality of ions into a mass filter configured to provide a high m/z cutoff greater than a maximum m/z ratio of ions associated with one or more analytes of interest in the sample so as to allow passage of the analyte ions while inhibiting passage of ions having m/z ratios above said high m/z cutoff, and performing a mass analysis of ions passing through said mass filter. In a related aspect, a mass spectrometer is disclosed, which comprises an atmospheric pressure ion source, a first mass filter, a user interface and a controller.
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公开(公告)号：US20230238230A1
公开(公告)日：2023-07-27
申请号：US17999814
申请日：2021-05-25
发明人： Thomas R. COVEY , Chang LIU
CPC分类号： H01J49/0413 , H01J49/165 , B25J15/0052
摘要： Technology for analyzing collections of substance samples. Systems in accordance with the disclosure can include one or more sample handlers, sample capture devices, mass analysis instruments, and controllers; the controllers being operative, in accordance with instructions received from at least one of an operator input device and machine-interpretable instructions stored in memory accessible by the controller, to generate signals configured to cause the sample handler to collectively retrieve from a sample source a plurality of samples of one or more substances, and deliver the plurality of collected samples to the at least one sample capture device; cause the sample capture device to independently capture at least one of the collectively retrieved samples delivered by the sample handler, and transfer the at least one captured sample to a mass analysis instrument; and cause the mass analysis instrument to ionize and detect one or more particles of the transferred treated sample.
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公开(公告)号：US20240234117A9
公开(公告)日：2024-07-11
申请号：US18275342
申请日：2022-01-31
发明人： Thomas R. COVEY , Tim HAEBE , Chang LIU
CPC分类号： H01J49/0431 , H01J49/24
摘要： Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which an open port of a sampling probe for receiving a specimen may be exposed to washing solvent to wash the sampling probe while fluid within the sampling probe remains continuously flowing.
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公开(公告)号：US20240136168A1
公开(公告)日：2024-04-25
申请号：US18275342
申请日：2022-01-31
发明人： Thomas R. COVEY , Tim HAEBE , Chang LIU
CPC分类号： H01J49/0431 , H01J49/24
摘要： Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which an open port of a sampling probe for receiving a specimen may be exposed to washing solvent to wash the sampling probe while fluid within the sampling probe remains continuously flowing.
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公开(公告)号：US20240096611A1
公开(公告)日：2024-03-21
申请号：US18262852
申请日：2022-02-08
发明人： Thomas R. COVEY , Chang LIU , Hui ZHANG
IPC分类号： H01J49/04
CPC分类号： H01J49/0431 , H01J49/0454
摘要： A method of sampling an ejection of a sample from a liquid container includes disposing the liquid container adjacent an open port in-terface. The container includes a sampling port. The open port interface en-gages with the sampling port. The sample from the liquid container is eject-ed, through the sampling port, and into the open port interface. The sample is analyzed with a mass spectrometry device.
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