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公开(公告)号：US10731159B2
公开(公告)日：2020-08-04
申请号：US16692284
申请日：2019-11-22
发明人： Makoto Koizumi , Yoshiyuki Onishi , Takako Niwa , Masakazu Tamura , Yuji Kasuya
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , C07C219/16 , C07D211/22 , C07D211/46 , A61K9/127 , C12N15/11 , A61K47/54 , A61K9/10 , A61K47/18 , A61K47/22 , A61K47/28 , A61K47/44 , A61K48/00
摘要： The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.
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公开(公告)号：US10533176B2
公开(公告)日：2020-01-14
申请号：US15797824
申请日：2017-10-30
发明人： Makoto Koizumi , Yoshiyuki Onishi , Takako Niwa , Masakazu Tamura , Yuji Kasuya
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , C07C219/16 , C07D211/22 , C07D211/46 , A61K9/127 , C12N15/11 , A61K9/10 , A61K47/18 , A61K47/22 , A61K47/28 , A61K47/44 , A61K48/00 , A61K47/54
摘要： The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.
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公开(公告)号：US20150038738A1
公开(公告)日：2015-02-05
申请号：US14511386
申请日：2014-10-10
IPC分类号： C07C227/22 , C12P7/26
CPC分类号： C07C227/22 , C07B57/00 , C07C45/85 , C07C201/12 , C07C227/04 , C07C227/12 , C07C227/18 , C07C229/32 , C07C2602/20 , C12P7/02 , C12P7/26 , C12P41/002 , C07C49/627 , C07C205/50
摘要： An object of the present invention is to efficiently produce an optically active bicyclic compound. The optically active bicyclic compound is efficiently produced using an enzyme.
摘要翻译： 本发明的目的是有效地制备光学双环化合物。 使用酶有效地制备光学双环化合物。
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公开(公告)号：US11230709B2
公开(公告)日：2022-01-25
申请号：US16467224
申请日：2017-12-25
发明人： Kazumoto Iijima , Kandai Nozu , Akemi Shono , Makoto Koizumi , Yoshiyuki Onishi , Kiyosumi Takaishi , Tomomi Adachi
IPC分类号： C12N15/113 , A61K31/713 , A61P13/12
摘要： The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).
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公开(公告)号：US11958878B2
公开(公告)日：2024-04-16
申请号：US16966132
申请日：2019-03-05
发明人： Makoto Koizumi , Yoshiyuki Onishi , Takeshi Masuda , Mitsuhiro Iwamoto , Yukiko Sekiguchi , Kentaro Ito , Shinnosuke Tsuji , Masafumi Matsuo
IPC分类号： C07H21/02
CPC分类号： C07H21/02
摘要： The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to die cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5′ end of exon 5 of the G6PC gene with c.648C>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).
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公开(公告)号：US09803199B2
公开(公告)日：2017-10-31
申请号：US14903711
申请日：2014-07-07
发明人： Makoto Koizumi , Yoshiyuki Onishi , Takako Niwa , Masakazu Tamura , Yuji Kasuya
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , C07C219/16 , C07D211/22 , C07D211/46 , A61K47/48 , A61K9/127 , C12N15/11 , A61K9/10 , A61K47/18 , A61K47/22 , A61K47/28 , A61K47/44 , A61K48/00
CPC分类号： C12N15/113 , A61K9/10 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K47/18 , A61K47/22 , A61K47/28 , A61K47/44 , A61K47/543 , A61K48/0008 , A61K48/005 , C07C219/16 , C07D211/22 , C07D211/46 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.
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公开(公告)号：US09662310B2
公开(公告)日：2017-05-30
申请号：US14613145
申请日：2015-02-03
IPC分类号： A61K31/4164 , A61K31/4178 , A61K31/4725 , A61K31/506 , A61K31/4709 , A61K31/4439 , A61K31/427 , C07D233/64 , C07D401/04
CPC分类号： A61K31/4164 , A61K31/4178 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506 , C07D233/64 , C07D401/04
摘要： A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein R1 represents a C1 to C6 alkyl group which may be substituted by one to three groups selected from substituent group A, or the like (substituent group A: a hydroxy group, a halogeno group, a cyano group, a nitro group, an amino group, a carboxy group, a C1 to C3 alkyl group, etc.); R2, R3, and R8 each independently represent a hydrogen atom or a C1 to C3 alkyl group; R4, R5, R6, R7, R9, and R10 each independently represent a hydrogen atom or the like; and R11 represents a hydrogen atom or the like, has TAFIa enzyme inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, or the like.
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公开(公告)号：US09394235B2
公开(公告)日：2016-07-19
申请号：US14511386
申请日：2014-10-10
IPC分类号： C07C227/22 , C07C227/12 , C07C229/32 , C07C45/85 , C12P41/00 , C12P7/02 , C12P7/26 , C07C201/12 , C07C227/04 , C07C227/18 , C07B57/00
CPC分类号： C07C227/22 , C07B57/00 , C07C45/85 , C07C201/12 , C07C227/04 , C07C227/12 , C07C227/18 , C07C229/32 , C07C2602/20 , C12P7/02 , C12P7/26 , C12P41/002 , C07C49/627 , C07C205/50
摘要： An object of the present invention is to efficiently produce an optically active bicyclic compound. The optically active bicyclic compound is efficiently produced using an enzyme.
摘要翻译： 本发明的目的是有效地制备光学双环化合物。 使用酶有效地制备光学双环化合物。
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