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公开(公告)号：US10287613B2
公开(公告)日：2019-05-14
申请号：US15875984
申请日：2018-01-19
发明人： Scott Franklin , Aravind Somanchi , George N. Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC分类号： C12N9/88 , C12P7/64 , C12N9/02 , C12N9/10 , C12N9/16 , A23D9/00 , C07C57/03 , C07J9/00 , C12P33/00 , C12N15/82 , A23D9/013 , C11B1/00 , C12N9/24 , C12N15/113 , C12R1/89
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
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公开(公告)号：US20190100780A1
公开(公告)日：2019-04-04
申请号：US16125580
申请日：2018-09-07
发明人： Scott Franklin , Aravind Somanchi , Janice Wee , George Rudenko , Jeffrey L. Moseley , Walter Rakitsky , Xinhua Zhao , Riyaz Bhat
摘要： Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty acid hydroxylase, a desaturase enzyme, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
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公开(公告)号：US10053715B2
公开(公告)日：2018-08-21
申请号：US14506491
申请日：2014-10-03
发明人： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Jeffrey L. Moseley
CPC分类号： C12P7/64 , C11C1/002 , C11D9/00 , C12P7/6409 , C12Y203/01041 , C12Y301/02014
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
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公开(公告)号：US20200032302A1
公开(公告)日：2020-01-30
申请号：US16373496
申请日：2019-04-02
发明人： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC分类号： C12P7/64 , C12N15/113 , C12N9/24 , C12N15/82 , C12P33/00 , C07J9/00 , C07C57/03 , A23D9/00 , C11B1/00 , A23D9/013 , C12N9/16 , C12N9/10 , C12N9/02
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
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公开(公告)号：US20180327758A1
公开(公告)日：2018-11-15
申请号：US15985576
申请日：2018-05-21
发明人： Scott Franklin , Aravind Somanchi , Janice Wee , George Rudenko , Jeffrey L. Moseley , Walt Rakitsky
IPC分类号： C12N15/79 , C12N15/82 , A23K20/158 , A23D7/00 , A23D9/00 , C11B1/00 , C11C3/00 , C12N9/02 , C12N9/16 , C12N9/26 , C12P7/64 , C12N9/40 , C12N15/67
CPC分类号： C12N15/79 , A23D7/00 , A23D9/00 , A23K20/158 , C11B1/00 , C11C3/00 , C12N9/0071 , C12N9/16 , C12N9/2431 , C12N9/2465 , C12N15/67 , C12N15/8216 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12Y114/19001 , C12Y301/02 , C12Y301/02014 , C12Y302/01022 , C12Y302/01026 , Y02E50/13 , Y02P30/20 , Y02T50/678
摘要： Methods and compositions for the production of food compositions, oils, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing food compositions, and transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
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公开(公告)号：US09969990B2
公开(公告)日：2018-05-15
申请号：US14796406
申请日：2015-07-10
发明人： David Davis , George Rudenko , Aravind Somanchi , Jason Casolari , Scott Franklin , Aren Ewing
CPC分类号： C12N9/1029 , C12N15/82 , C12P7/64 , C12P7/6463 , C12P33/00 , C12Y203/01041
摘要： The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in nucleic acid constructs, vectors or host cells. Expression of the gene products can alter the fatty acid profile of host cells. The KAS genes can be combined with a FATA or FATB thioesterase gene to create a cell that produces an increased amount of C8-C16 fatty acids. Suitable host cells include plastidic cells of plants or microalgae. Oleaginous microalga host cells with the new genes are disclosed.
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公开(公告)号：US20210130858A1
公开(公告)日：2021-05-06
申请号：US16866877
申请日：2020-05-05
发明人： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC分类号： C12P7/64 , C12N9/02 , C12N9/10 , C12N9/16 , A23D9/013 , C11B1/00 , A23D9/00 , C07C57/03 , C07J9/00 , C12P33/00 , C12N15/82 , C12N9/24 , C12N15/113
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
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公开(公告)号：US10100341B2
公开(公告)日：2018-10-16
申请号：US14974983
申请日：2015-12-18
发明人： Scott Franklin , Aravind Somanchi , Janice Wee , George Rudenko , Jeffrey L. Moseley , Walter Rakitsky , Xinhua Zhao , Riyaz Bhat
摘要： Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty acid hydroxylase, a desaturase enzyme, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
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公开(公告)号：US10006034B2
公开(公告)日：2018-06-26
申请号：US14819117
申请日：2015-08-05
发明人： Scott Franklin , Aravind Somanchi , Janice Wee , George Rudenko , Jeffrey L. Moseley , Walt Rakitsky
IPC分类号： C12N15/79 , C12N9/16 , C12P7/64 , C12N15/82 , A23D7/00 , A23D9/00 , C11B1/00 , C11C3/00 , C12N9/02 , C12N9/26 , C12N9/40 , C12N15/67 , A23K20/158
CPC分类号： C12N15/79 , A23D7/00 , A23D9/00 , A23K20/158 , C11B1/00 , C11C3/00 , C12N9/0071 , C12N9/16 , C12N9/2431 , C12N9/2465 , C12N15/67 , C12N15/8216 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12Y114/19001 , C12Y301/02 , C12Y301/02014 , C12Y302/01022 , C12Y302/01026 , Y02E50/13 , Y02P30/20 , Y02T50/678
摘要： Methods and compositions for the production of food compositions, oils, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing food compositions, and transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
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公开(公告)号：US10316299B2
公开(公告)日：2019-06-11
申请号：US15950048
申请日：2018-04-10
发明人： David Davis , George N. Rudenko , Aravind Somanchi , Jason Casolari , Scott Franklin , Aren Ewing
摘要： The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in nucleic acid constructs, vectors or host cells. Expression of the gene products can alter the fatty acid profile of host cells. The KAS genes can be combined with a FATA or FATB thioesterase gene to create a cell that produces an increased amount of C8-C16 fatty acids. Suitable host cells include plastidic cells of plants or microalgae. Oleaginous microalga host cells with the new genes are disclosed.
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