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    POLY(ESTER AMIDE)S AND POLY(ESTER ETHER AMIDE)S WITH ALIPHATIC POLYESTERS, METHOD OF MAKING SAME, AND USES THEREOF
    1.
    发明申请
    POLY(ESTER AMIDE)S AND POLY(ESTER ETHER AMIDE)S WITH ALIPHATIC POLYESTERS, METHOD OF MAKING SAME, AND USES THEREOF 审中-公开
    聚酯（ESTER AMIDE）S和聚酯（ESTER ETHER AMIDE）S，其制备方法及其用途

    公开(公告)号：US20140213738A1

    公开(公告)日：2014-07-31

    申请号：US14342144

    申请日：2012-09-03

    申请人： Chih-Chang Chu ,  Jun Wu ,  Kai Guo

    发明人： Chih-Chang Chu ,  Jun Wu ,  Kai Guo

    IPC分类号： C08G69/44

    CPC分类号： C08G69/44 ,  C08G69/40 ,  C08L77/12

    摘要： Polymers and copolymers having one or more aliphatic polyester groups or blocks. For example, the aliphatic polyester groups or blocks can be derived from a caprolactone such as, for example, ε-caprolactone. The polymers and copolymers can have desirable properties such as, for example, improved solubility and improved thermal properties.

    摘要翻译： 具有一个或多个脂族聚酯基团或嵌段的聚合物和共聚物。 例如，脂族聚酯基团或嵌段可以衍生自己内酯，例如ε-己内酯。 聚合物和共聚物可以具有所需的性质，例如，改进的溶解度和改善的热性能。

    Unsaturated poly(ester-amide) biomaterials
    2.
    发明授权
    Unsaturated poly(ester-amide) biomaterials 有权
    不饱和聚（酯 - 酰胺）生物材料

    公开(公告)号：US07863406B2

    公开(公告)日：2011-01-04

    申请号：US11587530

    申请日：2005-05-31

    申请人： Chih-Chang Chu ,  Ramaz Katsarava ,  Kai Guo

    发明人： Chih-Chang Chu ,  Ramaz Katsarava ,  Kai Guo

    IPC分类号： C08G69/10 ,  C08G69/44 ,  C08L77/04 ,  C08L77/12

    CPC分类号： C08G69/44 ,  A61K47/593 ,  A61K47/595 ,  C08L2201/06

    摘要： Biodegradable poly(ester-amides) are synthesized from amino acids, diols and dicarboxylic acids where one or both of the diols and dicarboxylic acids contain unsaturation; e.g., from di-p-nitrophenyl dicarboxylates and p-toluenesulfonic acid salts of bis(alpha-amino acid) disesters of diols where one or both of the dicarboxylate and diol moieties contain unsaturation or from di-p-nitrophenyl dicarboxylates, and p-toluene-sulfonic acid salts of bis(alpha-amino acid) diesters of diols and p-toluenesulfonic acid salt of lysine ester where one or both of the dicarboxylate and diol moieties contain unsaturation. The polymers are useful as biodegradable carriers for drugs of other bioactive agents.

    摘要翻译： 由氨基酸，二醇和二羧酸合成可生物降解的聚（酯 - 酰胺），其中二醇和二羧酸之一或二者均含有不饱和键; 例如二羧酸二酯和二羧酸二酯部分含有不饱和键的双（α-氨基酸）二酯的双对硝基苯基二羧酸酯和对甲苯磺酸盐，或二羧酸二对硝基苯酯， 二元醇的双（α-氨基酸）二酯和赖氨酸酯的对甲苯磺酸盐的甲苯磺酸盐，其中二羧酸酯和二醇部分中的一个或两个都含有不饱和键。 聚合物可用作其他生物活性剂药物的可生物降解载体。

    Unsaturated poly(ester-amide) biomaterials
    3.
    发明申请
    Unsaturated poly(ester-amide) biomaterials 有权
    不饱和聚（酯 - 酰胺）生物材料

    公开(公告)号：US20070167605A1

    公开(公告)日：2007-07-19

    申请号：US11587530

    申请日：2005-05-31

    申请人： Chih-Chang Chu ,  Ramaz Katsarava ,  Kai Guo

    发明人： Chih-Chang Chu ,  Ramaz Katsarava ,  Kai Guo

    IPC分类号： C08G69/08

    CPC分类号： C08G69/44 ,  A61K47/593 ,  A61K47/595 ,  C08L2201/06

    摘要： Biodegradable poly(ester-amides) are synthesized from amino acids, diols and dicarboxylic acids where one or both of the diols and dicarboxylic acids contain unsaturation; e.g., from di-p-nitrophenyl dicarboxylates and p-toluenesulfonic acid salts of bis(alpha-amino acid) disesters of diols where one or both of the dicarboxylate and diol moieties contain unsaturation or from di-p-nitrophenyl dicarboxylates, and p-toluene-sulfonic acid salts of bis(alpha-amino acid) diesters of diols and p-toluenesulfonic acid salt of lysine ester where one or both of the dicarboxylate and diol moieties contain unsaturation. The polymers are useful as biodegradable carriers for drugs of other bioactive agents.

    摘要翻译： 由氨基酸，二醇和二羧酸合成可生物降解的聚（酯 - 酰胺），其中二醇和二羧酸之一或二者均含有不饱和键; 例如二羧酸二酯和二羧酸二酯部分含有不饱和键的双（α-氨基酸）二酯的双对硝基苯基二羧酸酯和对甲苯磺酸盐，或二羧酸二对硝基苯酯， 二元醇的双（α-氨基酸）二酯和赖氨酸酯的对甲苯磺酸盐的甲苯磺酸盐，其中二羧酸酯和二醇部分中的一个或两个都含有不饱和键。 聚合物可用作其他生物活性剂药物的可生物降解载体。

    UNSATURATED POLY(ESTER-AMIDE) AND POLY(ETHER ESTER AMIDE) BIOMATERIALS
    4.
    发明申请
    UNSATURATED POLY(ESTER-AMIDE) AND POLY(ETHER ESTER AMIDE) BIOMATERIALS 审中-公开
    不饱和多糖（酯化酰胺）和聚（醚类）生物体

    公开(公告)号：US20110015367A1

    公开(公告)日：2011-01-20

    申请号：US12591488

    申请日：2009-11-20

    申请人： Chih-Chang Chu ,  Ramaz Katsarava ,  Kai Guo

    发明人： Chih-Chang Chu ,  Ramaz Katsarava ,  Kai Guo

    IPC分类号： C08G69/44

    CPC分类号： C08G69/44 ,  A61K47/59 ,  A61K47/593 ,  A61K47/595 ,  C08B37/0072 ,  C08G69/42 ,  C08L2201/06

    摘要： Functionalized poly(ester-amides) and poly(ether ester amides) polymers having the structural formula: wherein R1 is (C2-C28)alkylene, or (C2-C28)alkylene substituted with a side chain selected from the group consisting of (2-carboxyethyl)thio, (2-hydroxethyl)thio, (2-aminoethyl)thio and (2-aminoethyl)thio hydrochloride salt; R3 is selected from the group consisting of hydrogen, (C1-C6)alkyl, and (C6-C10)aryl (C1-C6)alkyl; and R4 is selected from the group consisting of (C2-C28)alkyloxy, (C2-C28)alkylene substituted with a side chain selected from the group consisting of (2-carboxyethyl)thio, (2-hydroxethyl) thio, (2-aminoethyl)thio and (2-aminoethyl)thio hydrochloride salt, and —C2H4(OC2H4)x; x ranges from 2-4; n ranges from 5 to 150; and wherein at least one of R1 and R4 attaches a functional group.

    摘要翻译： 具有以下结构式的官能化聚（酯 - 酰胺）和聚（醚酯酰胺）聚合物：其中R1是（C2-C28）亚烷基，或被选自（2）的侧链的侧链取代的（C 2 -C 28） （2-羟基乙基）硫基，（2-氨基乙基）硫基和（2-氨基乙基）硫代盐酸盐; R3选自氢，（C1-C6）烷基和（C6-C10）芳基（C1-C6）烷基; 并且R 4选自（C 2 -C 28）烷氧基，被选自（2-羧乙基）硫代，（2-羟乙基）硫基，（2-羟基乙基）硫基，（2-羟基乙基） 氨基乙基）硫代和（2-氨基乙基）硫代盐酸盐和-C2H4（OC2H4）x; x范围从2-4; n范围从5到150; 并且其中R1和R4中的至少一个连接官能团。

    Hydrogel-forming system with hydrophobic and hydrophilic components
    9.
    发明授权
    Hydrogel-forming system with hydrophobic and hydrophilic components 失效
    具有疏水和亲水组分的水凝胶形成体系

    公开(公告)号：US06709668B2

    公开(公告)日：2004-03-23

    申请号：US10369676

    申请日：2003-02-21

    申请人： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    发明人： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    IPC分类号： C09D400

    CPC分类号： C08L5/02 ,  A61K9/205 ,  A61K47/36 ,  C08B37/0021 ,  C08G18/6484 ,  C08G18/8108 ,  C08G2210/00 ,  C08L67/07 ,  Y10S525/937 ,  C08L2666/02 ,  C08L2666/26

    摘要： A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g., dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom.

    摘要翻译： 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团引入化合物反应的含羟基的多糖（例如，葡聚糖），可通过自由基聚合反应形成含有 含有疏水和亲水组分的三维交联聚合物网络。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。

    Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
    10.
    发明授权
    Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers 失效
    具有可生物降解聚合物骨架的反应性接枝聚合物和制备活性可生物降解聚合物的方法

    公开(公告)号：US5610241A

    公开(公告)日：1997-03-11

    申请号：US646060

    申请日：1996-05-07

    申请人： Keun H. Lee ,  Chee Y. Won ,  Chih-Chang Chu

    发明人： Keun H. Lee ,  Chee Y. Won ,  Chih-Chang Chu

    IPC分类号： C08G63/685 ,  C08G63/91 ,  C08G63/08

    CPC分类号： C08G63/912 ,  C08G63/6852

    摘要： Graft polymers with reactive groups for linking to peptides for use in tissue engineering and to drugs to provide drug delivery systems and useful per se to release amino acids and useful, for example, for wound closure devices, pins, screws, anastomosis rings, and surgical implants, consist essentially of biodegradable homopolymer or copolymer backbone joined at carbon alpha to carbon of backbone carbonyl group, to side chain amino acid pendant group at a carbonyl moiety of said pendant group wherein said side chain contains reactive amino acid group. The graft polymers are prepared by reacting amino acid halide having other reactive groups protected, with biodegradable polymer containing carbanion on carbon alpha to carbon of carbonyl group, and then deprotecting the protected groups. Biodegradable polymer containing carbanion on carbon alpha to carbon of carbonyl group, for use in preparing the graft polymers herein or for otherwise reacting, e.g., for surface crosslinking, attaching nitric oxide derivatives, attaching biochemicals or for grafting hydrophilic or hydrophobic agents to control the hydrophilicity or hydrophobicity, is prepared by reacting biodegradable homopolymer or copolymer containing carbonyl group and carbon alpha to the carbon of the carbonyl group and having H atom on the carbon alpha to group carbonyl carbon, with a base to form carbanion on carbon alpha to carbonyl carbon.

    摘要翻译： 具有用于组合工程中用于连接肽的反应性基团的接枝聚合物和用于提供药物递送系统的药物并且本身可用于释放氨基酸并且可用于例如伤口闭合装置，针，螺钉，吻合环和手术 植入物基本上由在骨架羰基碳碳键连接的可生物降解的均聚物或共聚物主链组成，所述侧链羰基部分的侧链氨基酸侧基包含反应性氨基酸基团。 接枝聚合物的制备是将具有保护的其它反应性基团的氨基酸卤化物与碳上碳负离子的生物可降解聚合物与羰基的碳反应，然后使保护基团脱保护。 用于制备本文的接枝聚合物或以其它方式反应的例如用于表面交联，附着一氧化氮衍生物，附着生物化学物质或用于接枝亲水或疏水剂以控制亲水性的羰基碳碳 - 碳上的碳负离子的可生物降解聚合物 或疏水性，通过将含有羰基和碳α的可生物降解的均聚物或含有羰基的共聚物与羰基碳上具有H原子并且具有碳原子数为羰基碳的碳原子反应而制备，从而在羰基碳碳上形成碳负离子。