公开(公告)号：US5610241A

公开(公告)日：1997-03-11

申请号：US646060

申请日：1996-05-07

申请人： Keun H. Lee ,  Chee Y. Won ,  Chih-Chang Chu

发明人： Keun H. Lee ,  Chee Y. Won ,  Chih-Chang Chu

IPC分类号： C08G63/685 ,  C08G63/91 ,  C08G63/08

CPC分类号： C08G63/912 ,  C08G63/6852

摘要： Graft polymers with reactive groups for linking to peptides for use in tissue engineering and to drugs to provide drug delivery systems and useful per se to release amino acids and useful, for example, for wound closure devices, pins, screws, anastomosis rings, and surgical implants, consist essentially of biodegradable homopolymer or copolymer backbone joined at carbon alpha to carbon of backbone carbonyl group, to side chain amino acid pendant group at a carbonyl moiety of said pendant group wherein said side chain contains reactive amino acid group. The graft polymers are prepared by reacting amino acid halide having other reactive groups protected, with biodegradable polymer containing carbanion on carbon alpha to carbon of carbonyl group, and then deprotecting the protected groups. Biodegradable polymer containing carbanion on carbon alpha to carbon of carbonyl group, for use in preparing the graft polymers herein or for otherwise reacting, e.g., for surface crosslinking, attaching nitric oxide derivatives, attaching biochemicals or for grafting hydrophilic or hydrophobic agents to control the hydrophilicity or hydrophobicity, is prepared by reacting biodegradable homopolymer or copolymer containing carbonyl group and carbon alpha to the carbon of the carbonyl group and having H atom on the carbon alpha to group carbonyl carbon, with a base to form carbanion on carbon alpha to carbonyl carbon.

摘要翻译： 具有用于组合工程中用于连接肽的反应性基团的接枝聚合物和用于提供药物递送系统的药物并且本身可用于释放氨基酸并且可用于例如伤口闭合装置，针，螺钉，吻合环和手术 植入物基本上由在骨架羰基碳碳键连接的可生物降解的均聚物或共聚物主链组成，所述侧链羰基部分的侧链氨基酸侧基包含反应性氨基酸基团。 接枝聚合物的制备是将具有保护的其它反应性基团的氨基酸卤化物与碳上碳负离子的生物可降解聚合物与羰基的碳反应，然后使保护基团脱保护。 用于制备本文的接枝聚合物或以其它方式反应的例如用于表面交联，附着一氧化氮衍生物，附着生物化学物质或用于接枝亲水或疏水剂以控制亲水性的羰基碳碳 - 碳上的碳负离子的可生物降解聚合物 或疏水性，通过将含有羰基和碳α的可生物降解的均聚物或含有羰基的共聚物与羰基碳上具有H原子并且具有碳原子数为羰基碳的碳原子反应而制备，从而在羰基碳碳上形成碳负离子。