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公开(公告)号：US09631173B2
公开(公告)日：2017-04-25
申请号：US14934434
申请日：2015-11-06
Applicant: CPSI Holdings, LLC
Inventor： John G. Baust , Joshua T. Smith , Kimberly L. Santucci , Kristi K. Snyder , Anthony T. Robilotto , Robert G. Van Buskirk , John M. Baust , William L. Corwin , Jennie F. McKain
CPC classification number: C12M21/08 , C12M25/06 , C12M25/14 , C12M27/00 , C12M29/00 , C12N5/0062 , C12N5/0068 , C12N5/0697 , C12N2537/00 , G01N33/5008 , G01N33/5017
Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
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公开(公告)号：US20220205589A1
公开(公告)日：2022-06-30
申请号：US17655369
申请日：2022-03-18
Applicant: CPSI Holdings LLC
Inventor： John M. Baust , Joshua T. Smith , Anthony T. Robilotto , Jennie F. McKain
Abstract: A method of generating a pressurized, sub-cooled mixed-phase cryogen is disclosed, including providing a cryogenic system including a reservoir containing a liquid cryogen; and a heat exchange coil immersed in the liquid cryogen, the heat exchange coil having an input end and an output end not immersed in the liquid cryogen; introducing a pressurized gas cryogen to the input end of the heat exchange coil; cooling the pressurized gas cryogen within the heat exchange coil; and collecting the pressurized gas cryogen at an output end of the heat exchange coil.
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公开(公告)号：US11306871B2
公开(公告)日：2022-04-19
申请号：US16042411
申请日：2018-07-23
Applicant: CPSI Holdings LLC
Inventor： John M. Baust , Joshua T. Smith , Anthony T. Robilotto , Jennie F. McKain
Abstract: A cryogenic system as well as a method of generating a pressurized, sub-cooled mixed-phase cryogen and a method of delivering such a cryogen to a cryoprobe are disclosed. In an embodiment, the cryogenic system includes a reservoir containing a liquid cryogen and a sub-cooling coil immersed in the liquid cryogen. The cryogen is supplied to the sub-cooling coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the sub-cooling coil. This pressurized mixed phase cryogen is provided via supply line to a cryo-device for use.
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公开(公告)号：US20160097583A1
公开(公告)日：2016-04-07
申请号：US14876087
申请日：2015-10-06
Applicant: CPSI Holdings LLC
Inventor： John M. Baust , Joshua T. Smith , William Corwin , Kristi Snyder , Anthony T. Robilotto
CPC classification number: C12M41/12 , B01L7/00 , B01L2300/023 , B01L2300/024 , B01L2300/0809 , B01L2300/0829 , B01L2300/0854 , B01L2300/0887 , B01L2300/14 , B01L2300/1822 , B01L2300/185 , C12M41/22 , C12M41/48
Abstract: A system for heating or cooling a sample is disclosed, which includes an insulated chamber; at least one of a heater or a cooling pad disposed within the chamber; and at least one compliant, fluid filled pillow. The at least one compliant, fluid-filled pillow is disposed in the chamber and adjacent to the at least one thermal device while being heated or cooled to a desired temperature by the heater or the cooling pad, and upon reaching the desired temperature, the at least one compliant, fluid filled pillow substantially conforms to a container containing the sample.
Abstract translation: 公开了一种用于加热或冷却样品的系统，其包括绝缘室; 设置在所述室内的加热器或冷却垫中的至少一个; 和至少一个顺从的，充满流体的枕头。 至少一个顺从的流体填充的枕头设置在腔室中并且邻近于至少一个热装置，同时通过加热器或冷却垫被加热或冷却到期望的温度，并且在达到所需温度时， 至少一个顺从的，充满流体的枕头基本上符合容纳样品的容器。
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公开(公告)号：US20150282858A1
公开(公告)日：2015-10-08
申请号：US14678393
申请日：2015-04-03
Applicant: CPSI Holdings LLC
Inventor： John M. Baust , Jennie F. McKain , Anthony T. Robilotto , Joshua T. Smith
IPC: A61B18/02
CPC classification number: A61B18/02 , A61B2018/00011 , A61B2018/00041 , A61B2018/00166 , A61B2018/00172 , A61B2018/0025 , A61B2018/00351 , A61B2018/00488 , A61B2018/00577 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2018/0212 , A61B2018/0262 , A61B2018/0281
Abstract: A thermal regulation catheter system and method of use are disclosed, for moderating the temperature and other parameters of tissue surrounding a target tissue for an ablation procedure, or for performing a thermal treatment procedure. In an embodiment, the device includes a catheter having a shaft with a fluid supply line and a fluid return line disposed therein, and an inflatable heat exchange vessel at a distal end of the shaft. The fluid supply line supplies fluid to inflate the heat exchange vessel, and the fluid return line conducts fluid away from the heat exchange vessel.
Abstract translation: 公开了一种热调节导管系统和使用方法，用于缓和用于消融过程的靶组织周围的组织的温度和其它参数，或用于执行热处理程序。 在一个实施例中，该装置包括导管，该导管具有带有流体供应管线和设置在其中的流体返回管线的轴，以及在轴的远端处的可膨胀的热交换容器。 流体供应管线供应流体以使热交换容器膨胀，流体返回管线将流体从热交换容器导出。
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Patent Agency Ranking
公开(公告)号：US10054262B2
公开(公告)日：2018-08-21
申请号：US14687449
申请日：2015-04-15
Applicant: CPSI Holdings LLC
Inventor： John M. Baust , Joshua T. Smith , Anthony T. Robilotto , Jennie F. McKain
CPC classification number: F17C1/00 , A61B18/02 , A61B2018/00714 , A61B2018/00744 , A61B2018/00791 , A61B2018/0293 , A61B2090/064 , F17C3/00 , F17C5/02 , F17C2201/0109 , F17C2201/032 , F17C2201/056 , F17C2203/0329 , F17C2203/0391 , F17C2203/0643 , F17C2205/0107 , F17C2205/0161 , F17C2205/0367 , F17C2221/011 , F17C2221/012 , F17C2221/014 , F17C2221/016 , F17C2221/017 , F17C2221/035 , F17C2223/0169 , F17C2223/035 , F17C2223/036 , F17C2227/0341 , F17C2227/0353 , F17C2227/0374 , F17C2250/032 , F17C2250/0408 , F17C2250/0439 , F17C2270/02 , F17C2270/0509
Abstract: A cryogenic system as well as a method of generating a pressurized, sub-cooled mixed-phase cryogen and a method of delivering such a cryogen to a cryoprobe are disclosed. In an embodiment, the cryogenic system includes a reservoir containing a liquid cryogen and a sub-cooling coil immersed in the liquid cryogen. The cryogen is supplied to the sub-cooling coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the sub-cooling coil. This pressurized mixed phase cryogen is provided via supply line to a cryo-device for use.
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公开(公告)号：US11419656B2
公开(公告)日：2022-08-23
申请号：US14678393
申请日：2015-04-03
Applicant: CPSI Holdings LLC
Inventor： John M. Baust , Jennie F. McKain , Anthony T. Robilotto , Joshua T. Smith
Abstract: A thermal regulation catheter system and method of use are disclosed, for moderating the temperature and other parameters of tissue surrounding a target tissue for an ablation procedure, or for performing a thermal treatment procedure. In an embodiment, the device includes a catheter having a shaft with a fluid supply line and a fluid return line disposed therein, and an inflatable heat exchange vessel at a distal end of the shaft. The fluid supply line supplies fluid to inflate the heat exchange vessel, and the fluid return line conducts fluid away from the heat exchange vessel.
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公开(公告)号：US10196598B2
公开(公告)日：2019-02-05
申请号：US14876087
申请日：2015-10-06
Applicant: CPSI Holdings LLC
Inventor： John M. Baust , Joshua T. Smith , William Corwin , Kristi Snyder , Anthony T. Robilotto
Abstract: A system for heating or cooling a sample is disclosed, which includes an insulated chamber; at least one of a heater or a cooling pad disposed within the chamber; and at least one compliant, fluid filled pillow. The at least one compliant, fluid-filled pillow is disposed in the chamber and adjacent to the at least one thermal device while being heated or cooled to a desired temperature by the heater or the cooling pad, and upon reaching the desired temperature, the at least one compliant, fluid filled pillow substantially conforms to a container containing the sample.
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公开(公告)号：US09932551B2
公开(公告)日：2018-04-03
申请号：US15463448
申请日：2017-03-20
Applicant: CPSI Holdings, LLC
Inventor： John G. Baust , Joshua T. Smith , Kimberly L. Santucci , Kristi K. Snyder , Anthony T. Robilotto , Robert G. Van Buskirk , John M. Baust , William L. Corwin , Jennie F. McKain
CPC classification number: C12M21/08 , C12M25/06 , C12M25/14 , C12M27/00 , C12M29/00 , C12N5/0062 , C12N5/0068 , C12N5/0697 , C12N2537/00 , G01N33/5008 , G01N33/5017
Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
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公开(公告)号：US12000536B2
公开(公告)日：2024-06-04
申请号：US17655369
申请日：2022-03-18
Applicant: CPSI Holdings LLC
Inventor： John M. Baust , Joshua T. Smith , Anthony T. Robilotto , Jennie F. McKain
CPC classification number: F17C1/00 , A61B18/02 , F17C3/00 , F17C5/02 , A61B2018/00714 , A61B2018/00744 , A61B2018/00791 , A61B2018/0293 , A61B2090/064 , F17C2201/0109 , F17C2201/032 , F17C2201/056 , F17C2203/0329 , F17C2203/0391 , F17C2203/0643 , F17C2205/0107 , F17C2205/0161 , F17C2205/0367 , F17C2221/011 , F17C2221/012 , F17C2221/014 , F17C2221/016 , F17C2221/017 , F17C2221/035 , F17C2223/0169 , F17C2223/035 , F17C2223/036 , F17C2227/0341 , F17C2227/0353 , F17C2227/0374 , F17C2250/032 , F17C2250/0408 , F17C2250/0439 , F17C2270/02 , F17C2270/0509
Abstract: A method of generating a pressurized, sub-cooled mixed-phase cryogen is disclosed, including providing a cryogenic system including a reservoir containing a liquid cryogen; and a heat exchange coil immersed in the liquid cryogen, the heat exchange coil having an input end and an output end not immersed in the liquid cryogen; introducing a pressurized gas cryogen to the input end of the heat exchange coil; cooling the pressurized gas cryogen within the heat exchange coil; and collecting the pressurized gas cryogen at an output end of the heat exchange coil.
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