公开(公告)号：US20230151060A1

公开(公告)日：2023-05-18

申请号：US17773733

申请日：2020-11-05

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Mikimasa TANADA ,  Koji TAKANO ,  Atsushi MATSUO ,  Minoru TAMIYA ,  Aya CHIYODA ,  Toshiya ITO ,  Takeo IIDA

IPC分类号： C07K7/64 ,  C07D211/38 ,  C07C271/22 ,  C07D213/55 ,  C07D213/65 ,  C07D213/64 ,  C07D213/61 ,  C07D205/04 ,  C07C323/09 ,  C07F5/02 ,  C07D309/12 ,  C07C317/04 ,  C07D409/12 ,  C07D333/28 ,  C07D295/15

CPC分类号： C07K7/64 ,  C07D211/38 ,  C07C271/22 ,  C07D213/55 ,  C07D213/65 ,  C07D213/64 ,  C07D213/61 ,  C07D205/04 ,  C07C323/09 ,  C07F5/025 ,  C07D309/12 ,  C07C317/04 ,  C07D409/12 ,  C07D333/28 ,  C07D295/15 ,  A61K38/00

摘要： The present inventors found cyclic peptide compounds that interact with Ras, and non-natural amino acids useful for the production of the cyclic peptide compounds. The inventors also found that the cyclic peptide compounds inhibit the binding between Ras and SOS. In addition, the inventors found specific non-natural amino acids contained in the cyclic peptide compounds and methods for production thereof.

公开(公告)号：US20240166689A1

公开(公告)日：2024-05-23

申请号：US18460300

申请日：2023-09-01

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Shiori KARIYUKI ,  Takeo IIDA ,  Miki KOJIMA ,  Ryuichi TAKEYAMA ,  Mikimasa TANADA ,  Tetsuo KOJIMA ,  Hitoshi IIKURA ,  Atsushi MATSUO ,  Takuya SHIRAISHI ,  Takashi EMURA ,  Kazuhiko NAKANO ,  Koji TAKANO ,  Kousuke ASOU ,  Takuya TORIZAWA ,  Ryusuke TAKANO ,  Nozomi HISADA ,  Naoaki MURAO ,  Atsushi OHTA ,  Kaori KIMURA ,  Yusuke YAMAGISHI ,  Tatsuya KATO

IPC分类号： C07K7/64 ,  C07H21/04 ,  C07K1/113 ,  C07K5/087 ,  C07K5/103 ,  C07K7/06 ,  C07K7/08 ,  C07K11/00 ,  C07K11/02 ,  C07K19/00 ,  C12P21/02

CPC分类号： C07K7/64 ,  C07H21/04 ,  C07K1/113 ,  C07K5/0812 ,  C07K5/1013 ,  C07K7/06 ,  C07K7/08 ,  C07K11/00 ,  C07K11/02 ,  C07K19/00 ,  C12P21/02 ,  A61K38/00

摘要： An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

公开(公告)号：US20240148821A1

公开(公告)日：2024-05-09

申请号：US18289451

申请日：2022-05-06

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Mikimasa TANADA ,  Koji TAKANO ,  Atsushi MATSUO ,  Minoru TAMIYA ,  Aya CHIYODA ,  Toshiya ITO ,  Takeo IIDA ,  Atsushi OHTA

IPC分类号： A61K38/12 ,  A61P35/02 ,  C07K7/64

CPC分类号： A61K38/12 ,  A61P35/02 ,  C07K7/64

摘要： The present inventors found cyclic peptide compounds that interact with Ras, and pharmaceutical compositions containing the cyclic peptide compounds or salts thereof, or solvates thereof.