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公开(公告)号：US20220324840A1
公开(公告)日：2022-10-13
申请号：US17713598
申请日：2022-04-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Godwin Kwame Kumi , Audris Huang , Satheesh Kesavan Nair , Bharat Dinkar Shimpukade , Suresh Babu Vishwa Krishna Penmetsa , James Aaron Balog
IPC: C07D401/14 , A61P35/00
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US11337970B2
公开(公告)日：2022-05-24
申请号：US16328449
申请日：2017-08-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Emily Charlotte Cherney , Weifang Shan , Liping Zhang , Susheel Jethanand Nara , Audris Huang , James Aaron Balog
IPC: A61K31/4709 , A61K31/4375 , A61K31/5025 , A61K31/517 , A61K39/395 , C07D401/08 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/056
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20210147383A1
公开(公告)日：2021-05-20
申请号：US16950978
申请日：2020-11-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Andrew P. DEGNAN , Godwin Kwame Kumi , Audris Huang , James Aaron Balog , Ashok Vinayak Purandare , Weifang Shan , Guo Li
IPC: C07D401/14 , C07D405/14 , C07D487/04 , C07D417/14 , C07D498/18
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR6R6 or C═O; Ring A is: and R1, R2, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20160022619A1
公开(公告)日：2016-01-28
申请号：US14776035
申请日：2014-03-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Audris Huang , Bin Chen , Libing Chen , Steven P. Seitz , Amy C. Hart , Jay A. Markwalder
IPC: A61K31/196 , A61K31/505 , A61K31/44 , A61K31/41 , A61K31/4245 , A61K31/42 , A61K31/36 , A61K31/27 , A61K31/216 , A61K31/18 , C07D239/42 , C07D241/42 , C07D213/84 , C07D213/75 , C07D271/12 , C07D261/14 , C07D257/04 , C07D317/66 , C07C271/28 , C07C69/743 , C07C275/42 , C07C311/47 , A61K45/06 , C07C233/55 , A61N5/10 , A61K31/498
CPC classification number: A61K31/196 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C69/743 , C07C233/55 , C07C235/38 , C07C255/44 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/47 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/02 , C07C2602/08 , C07C2602/14 , C07C2602/42 , C07D213/56 , C07D213/75 , C07D213/84 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07D261/14 , C07D271/12 , C07D317/66 , Y02A50/411 , Y02A50/414
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法，其利用 发明。
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公开(公告)号：US20220305144A1
公开(公告)日：2022-09-29
申请号：US17722628
申请日：2022-04-18
Applicant: Bristol-Myers Squibb Company
Inventor： David J. Donnelly , Erin Lee Cole , Richard Charles Burrell , Wesley A. Turley , Alban J. Allentoff , Michael Arthur Wallace , James Aaron Balog , Audris Huang , Mette Skinbjerg
IPC: A61K51/04 , C07B59/00 , C07D215/18 , G01N33/60
Abstract: The present invention relates to radiolabeled IDO1 inhibitors or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of IDO enzymes in mammals.
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Patent Agency Ranking
公开(公告)号：US20210253624A1
公开(公告)日：2021-08-19
申请号：US16849091
申请日：2018-10-16
Applicant: Bristol-Myers Squibb Company
Inventor： Brian E. FINK , Yufen Zhao , Libing Chen , Audris Huang
Abstract: The present invention is directed to compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10167254B2
公开(公告)日：2019-01-01
申请号：US15584818
申请日：2017-05-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weiwei Guo , Audris Huang , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Natesan Murugesan , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: A61K31/17 , C07C275/40 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/395 , C07C229/42 , C07C255/58 , C07D205/04 , C07D211/14 , C07D239/47 , C07D265/36 , C07D277/64 , C07D295/155 , C07D309/04 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D309/14 , C07D407/12 , C07D487/08 , C07D265/30 , C07D207/08 , C07D211/08 , C07D307/22 , C07C255/57 , C07C235/38 , C07C235/56 , C07C233/81 , C07C275/42 , C07D207/12 , C07D239/34 , C07D317/46 , C07D413/14 , C07D471/08 , C07C275/30 , A61K45/06
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US09895330B2
公开(公告)日：2018-02-20
申请号：US14903091
申请日：2014-07-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jay A Markwalder , James Aaron Balog , Audris Huang , Steven P Seitz
IPC: C07C233/55 , C07D257/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/12 , C07D413/12 , C07D487/08 , C07D405/12 , A61K31/196 , A61K31/41 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/4155 , A61K31/5377 , C07D417/12 , C07D261/08 , C07C255/57 , A61K45/06 , A61K31/427 , A61N5/10
CPC classification number: A61K31/196 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/06 , A61N5/10 , C07C233/55 , C07C255/57 , C07C2601/14 , C07D257/04 , C07D261/08 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/08 , Y02A50/411 , Y02A50/414
Abstract: There are disclosed compounds of Formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-di-oxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.
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公开(公告)号：US09765018B2
公开(公告)日：2017-09-19
申请号：US14897668
申请日：2014-07-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jay A. Markwalder , Steven P. Seitz , James Aaron Balog , Audris Huang , Sunil Kumar Mandal , David K. Williams , Amy C. Hart , Jennifer Inghrim
IPC: C07C275/42 , C07C311/51 , C07D213/75 , C07D257/04 , C07D401/04 , A61K31/18 , A61K31/41 , A61K31/44 , C07D213/79 , C07D307/86 , A61K31/196 , A61K31/277 , A61K31/343 , A61K31/4418 , A61K31/444 , A61K45/06 , C07C311/09 , C07D307/79
CPC classification number: C07C275/42 , A61K31/18 , A61K31/196 , A61K31/277 , A61K31/343 , A61K31/41 , A61K31/4418 , A61K31/444 , A61K45/06 , C07C311/09 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/75 , C07D213/79 , C07D257/04 , C07D307/79 , C07D307/86 , C07D401/04
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US09624188B2
公开(公告)日：2017-04-18
申请号：US14775976
申请日：2014-03-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Audris Huang , Bin Chen , Libing Chen , Weifang Shan
IPC: C07D305/06 , A61K31/196 , C07C275/42 , C07D239/42 , C07D241/42 , C07D255/02 , A61K31/337 , A61K31/41 , A61K31/42 , A61K31/498 , A61K31/505 , A61K45/06 , C07D261/14
CPC classification number: C07D305/06 , A61K31/196 , A61K31/337 , A61K31/41 , A61K31/42 , A61K31/498 , A61K31/505 , A61K45/06 , C07C275/42 , C07C2101/14 , C07C2601/14 , C07D239/42 , C07D241/42 , C07D255/02 , C07D261/14
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention. Formula (I).
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