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公开(公告)号：US11253525B2
公开(公告)日：2022-02-22
申请号：US16555431
申请日：2019-08-29
发明人： James Aaron Balog , Steven P. Seitz , Susheel Jethanand Nara , Saumya Roy , Srinivasan Thangathirupathy , Soodamani Thangavel , Srinivas Cheruku
IPC分类号： A61P35/00 , A61K31/17 , A61K31/44 , A61K31/50 , A61K31/136 , A61K31/275 , A61K31/351 , A61K31/428 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K31/5377 , C07C211/54 , C07C229/42 , C07C255/58 , C07C275/42 , C07D213/90 , C07D237/22 , C07D239/42 , C07D239/47 , C07D241/18 , C07D265/30 , C07D277/64 , C07D295/03 , C07D407/12 , C07D413/12
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the disclosure.
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公开(公告)号：US10961229B2
公开(公告)日：2021-03-30
申请号：US16502684
申请日：2019-07-03
发明人： Imadul Islam , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Srinivas Cheruku , Poornima Shetty , Grandhi Venkat Ram Krishna Mohan Gupta , John E. Macor
IPC分类号： C07D403/14 , C07D401/12 , C07D471/08 , A61P25/28 , A61P25/02 , A61P25/24 , A61P25/16 , C07D401/14 , C07D487/08
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US10399932B2
公开(公告)日：2019-09-03
申请号：US15564146
申请日：2016-04-01
发明人： James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Audris Huang , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC分类号： C07D309/14 , C07D405/12 , C07D413/12 , C07D335/02 , C07D211/10 , C07D265/30 , C07D409/12 , C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/395 , C07C229/42 , C07C255/58 , C07D205/04 , C07D211/14 , C07D239/47 , C07D265/36 , C07D277/64 , C07D295/155 , C07D309/04 , C07D401/12 , C07D405/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D407/12 , C07D487/08 , C07D207/08 , C07D211/08 , C07D307/22 , C07C255/57 , C07C235/38 , C07C235/56 , C07C233/81 , C07C275/42 , C07D207/12 , C07D239/34 , C07D317/46 , C07D413/14 , C07D471/08 , C07C275/30 , A61K45/06
摘要： There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20230167131A1
公开(公告)日：2023-06-01
申请号：US17799028
申请日：2021-02-11
发明人： Kumaravel Selvakumar , Venkatram Paidi , Srinivasan Thangathirupathy , Vijaya Kumar Cm , Tirupathi Rao Alajangi , Mallikarjun Reddy Sura , Krishna Mahadevu , Ramesh Kumar Sistla , Piyush Agarwal , Arul Mozhi Subbiah Karuppiah , Jalathi S. Nair , Ooha Morampudi , Manoranjan Panda , Joseph A. Tino , Robert J. Cherney , John V. Duncia , Daniel S. Gardner , T. G. Murali Dhar , Audrey Graham Ross , Paul E. Gormisky , Xiao Zhu , Boris M. Seletsky , Alyssa H. Antropow , Deqiang Niu , Zhengdong Zhu , Guobin Miao , Julio Herman Cuervo
IPC分类号： C07D519/00 , C07D471/04 , C07D487/04 , C07D409/14 , C07D405/14 , C07D413/14
CPC分类号： C07D519/00 , C07D471/04 , C07D487/04 , C07D409/14 , C07D405/14 , C07D413/14
摘要： The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity.
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公开(公告)号：US20210121453A1
公开(公告)日：2021-04-29
申请号：US17012781
申请日：2020-09-04
发明人： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC分类号： A61K31/454 , C07D403/04 , C07D401/04
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20180079712A1
公开(公告)日：2018-03-22
申请号：US15564146
申请日：2016-04-01
发明人： James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Audris Huang , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC分类号： C07C229/42 , C07C275/42 , C07D295/155 , C07D239/47 , C07D277/64 , C07D335/02 , C07D409/12 , C07D309/14 , C07D405/12 , C07D211/14 , C07D401/12 , C07D317/46 , C07D239/34 , C07D413/12 , C07D265/30 , C07C233/81 , C07D405/14 , C07D207/12 , C07D487/08 , C07D487/04 , C07D471/08 , C07D265/36 , C07D413/14
摘要： There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20160289171A1
公开(公告)日：2016-10-06
申请号：US15088211
申请日：2016-04-01
发明人： James Aaron Balog , Emily Charlotte Cherney , Weiwei Guo , Audris Huang , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Natesan Murugesan , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC分类号： C07C229/42 , A61K31/196 , C07D239/47 , A61K31/505 , C07C255/58 , A61K31/277 , C07C275/40 , A61K31/17 , C07D295/155 , A61K31/5375 , C07D277/64 , A61K31/428 , C07D335/02 , A61K31/382 , C07D409/12 , A61K31/506 , C07D309/04 , A61K31/351 , C07D405/12 , C07D211/14 , A61K31/445 , C07D401/12 , C07D413/12 , A61K31/5377 , C07D405/14 , C07D417/12 , C07D487/04 , A61K31/519 , A61K31/501 , C07D471/04 , A61K31/437 , C07D205/04 , A61K31/397 , A61K31/538 , C07D265/36 , A61K39/395
CPC分类号： C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
摘要翻译： 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法，其利用 发明。
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公开(公告)号：US10954225B2
公开(公告)日：2021-03-23
申请号：US16707382
申请日：2019-12-09
发明人： Imadul Islam , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Srinivas Cheruku , Poornima Shetty , John E. Macor
IPC分类号： C07D413/14 , C07D413/04 , A61K31/497 , A61K31/4523 , A61P25/24 , C07D413/12
摘要： The present disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) compounds are ligands for NR2B N-Methyl-D-aspartate (NMDA) receptor and thereby making them useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20200163949A1
公开(公告)日：2020-05-28
申请号：US16777114
申请日：2020-01-30
发明人： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC分类号： A61K31/454 , C07D401/04 , C07D403/04
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20190314358A1
公开(公告)日：2019-10-17
申请号：US16454831
申请日：2019-06-27
发明人： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC分类号： A61K31/454 , C07D403/04 , C07D401/04
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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