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公开(公告)号：US20210121453A1
公开(公告)日：2021-04-29
申请号：US17012781
申请日：2020-09-04
发明人： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC分类号： A61K31/454 , C07D403/04 , C07D401/04
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US10961229B2
公开(公告)日：2021-03-30
申请号：US16502684
申请日：2019-07-03
发明人： Imadul Islam , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Srinivas Cheruku , Poornima Shetty , Grandhi Venkat Ram Krishna Mohan Gupta , John E. Macor
IPC分类号： C07D403/14 , C07D401/12 , C07D471/08 , A61P25/28 , A61P25/02 , A61P25/24 , A61P25/16 , C07D401/14 , C07D487/08
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US10954225B2
公开(公告)日：2021-03-23
申请号：US16707382
申请日：2019-12-09
发明人： Imadul Islam , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Srinivas Cheruku , Poornima Shetty , John E. Macor
IPC分类号： C07D413/14 , C07D413/04 , A61K31/497 , A61K31/4523 , A61P25/24 , C07D413/12
摘要： The present disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) compounds are ligands for NR2B N-Methyl-D-aspartate (NMDA) receptor and thereby making them useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20200163949A1
公开(公告)日：2020-05-28
申请号：US16777114
申请日：2020-01-30
发明人： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC分类号： A61K31/454 , C07D401/04 , C07D403/04
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20190314358A1
公开(公告)日：2019-10-17
申请号：US16454831
申请日：2019-06-27
发明人： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC分类号： A61K31/454 , C07D403/04 , C07D401/04
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20180312491A1
公开(公告)日：2018-11-01
申请号：US15767386
申请日：2016-10-13
发明人： Imadul Islam , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Srinivas Cheruku , Poornima Shetty , Grandhi Venkat Ram Krishna Mohan Gupta , John E. Macor
IPC分类号： C07D403/14 , C07D401/14 , C07D487/08 , A61P25/24 , A61P25/28 , A61P25/02 , A61P25/16
CPC分类号： C07D403/14 , A61P25/02 , A61P25/16 , A61P25/24 , A61P25/28 , C07D401/12 , C07D401/14 , C07D471/08 , C07D487/08
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20130085138A1
公开(公告)日：2013-04-04
申请号：US13627130
申请日：2012-09-26
发明人： Dalton King , Richard E. Olson , John E. Macor , Imadul Islam , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier
IPC分类号： A61K31/4709 , A61K31/4245 , C07D413/14 , A61K31/501 , A61K31/498 , A61P29/00 , C07D487/04 , A61K31/519 , A61K31/506 , A61P25/24 , A61P25/28 , A61P25/16 , C07D413/12 , A61K31/538
CPC分类号： C07D413/12 , C07D271/113 , C07D401/12 , C07D403/08 , C07D413/06 , C07D413/08 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, antagonists of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
摘要翻译： 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是NR2B受体的配体，拮抗剂，可用于治疗中枢神经系统的各种疾病。
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公开(公告)号：US20180312495A1
公开(公告)日：2018-11-01
申请号：US15767385
申请日：2016-10-13
发明人： Imadul Islam , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Srinivas Cheruku , Poornima Shetty , John E. Macor
IPC分类号： C07D413/04 , A61P25/24 , C07D413/14 , C07D413/12
CPC分类号： C07D413/04 , C07D413/14
摘要： The present disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) compounds are ligands for NR2B N-Methyl-D-aspartate (NMD A) receptor and thereby making them useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20180250283A1
公开(公告)日：2018-09-06
申请号：US15971067
申请日：2018-05-04
发明人： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC分类号： A61K31/454 , C07D403/04 , C07D401/04
CPC分类号： A61K31/454 , C07D401/04 , C07D403/04
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：US20180110766A1
公开(公告)日：2018-04-26
申请号：US15846672
申请日：2017-12-19
发明人： Dalton King , Lorin A. Thompson, III , Jianliang Shi , Srinivasan Thangathirupathy , Jayakumar Sankara Warrier , Imadul Islam , John E. Macor
IPC分类号： A61K31/454 , C07D403/04 , C07D401/04
CPC分类号： A61K31/454 , C07D401/04 , C07D403/04
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
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