公开(公告)号：US20160101104A1

公开(公告)日：2016-04-14

申请号：US14974248

申请日：2015-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James H. Cook, II ,  Ivar M. McDonald ,  Dalton King ,  Richard E. Olson ,  Nenghui Wang ,  Christiana I. lwuagwu ,  F. Christopher Zusi ,  John E. Macor

IPC: A61K31/506

CPC classification number: A61K31/506 ,  A61K31/439 ,  C07D498/20 ,  C07D519/00

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

公开(公告)号：US20210121453A1

公开(公告)日：2021-04-29

申请号：US17012781

申请日：2020-09-04

Applicant: Bristol-Myers Squibb Company

Inventor： Dalton King ,  Lorin A. Thompson, III ,  Jianliang Shi ,  Srinivasan Thangathirupathy ,  Jayakumar Sankara Warrier ,  Imadul Islam ,  John E. Macor

IPC: A61K31/454 ,  C07D403/04 ,  C07D401/04

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

公开(公告)号：US20150342935A1

公开(公告)日：2015-12-03

申请号：US14820412

申请日：2015-08-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James H. Cook, II ,  Ivar M. McDonald ,  Dalton King ,  Richard E. Olson ,  Nenghui Wang ,  Christiana I. Iwuagwu ,  F. Christopher Zusi ,  John E. Macor

IPC: A61K31/439

CPC classification number: A61K31/506 ,  A61K31/439 ,  C07D498/20 ,  C07D519/00

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

公开(公告)号：US20190117638A1

公开(公告)日：2019-04-25

申请号：US16225850

申请日：2018-12-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dalton King ,  Lorin A. Thompson, III ,  Jianliang Shi ,  Srinivasan Thangathirupathy ,  Jayakumar Sankara Warrier ,  Imadul Islam ,  John E. Macor

IPC: A61K31/454 ,  C07D403/04 ,  C07D401/04

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

公开(公告)号：US20180000807A1

公开(公告)日：2018-01-04

申请号：US15706172

申请日：2017-09-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dalton King ,  Lorin A. Thompson, III ,  Jianliang Shi ,  Srinivasan Thangathirupathy ,  Jayakumar Sankara Warrier ,  Imadul Islam ,  John E. Macor

IPC: A61K31/454 ,  C07D403/04 ,  C07D401/04

CPC classification number: A61K31/454 ,  C07D401/04 ,  C07D403/04

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

公开(公告)号：US09221796B2

公开(公告)日：2015-12-29

申请号：US14589205

申请日：2015-01-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dalton King ,  Lorin A. Thompson, III ,  Jianliang Shi ,  Srinivasan Thangathirupathy ,  Jayakumar Sankara Warrier ,  Imadul Islam ,  John E. Macor

IPC: C07D403/04 ,  C07D401/04

CPC classification number: A61K31/454 ,  C07D401/04 ,  C07D403/04

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

Abstract translation: 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是NR2B受体的配体，可用于治疗中枢神经系统的各种疾病。

公开(公告)号：US20150191452A1

公开(公告)日：2015-07-09

申请号：US14589205

申请日：2015-01-05

Applicant: Bristol-Myers Squibb Company

Inventor： Dalton King ,  Lorin A. Thompson, III ,  Jianliang Shi ,  Srinivasan Thangathirupathy ,  Jayakumar Sankara Warrier ,  Imadul Islam ,  John E. Macor

IPC: C07D403/04 ,  C07D401/04

CPC classification number: A61K31/454 ,  C07D401/04 ,  C07D403/04

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

Abstract translation: 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是NR2B受体的配体，可用于治疗中枢神经系统的各种疾病。

公开(公告)号：US20200163949A1

公开(公告)日：2020-05-28

申请号：US16777114

申请日：2020-01-30

Applicant: Bristol-Myers Squibb Company

Inventor： Dalton King ,  Lorin A. Thompson, III ,  Jianliang Shi ,  Srinivasan Thangathirupathy ,  Jayakumar Sankara Warrier ,  Imadul Islam ,  John E. Macor

IPC: A61K31/454 ,  C07D401/04 ,  C07D403/04

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

公开(公告)号：US20190314358A1

公开(公告)日：2019-10-17

申请号：US16454831

申请日：2019-06-27

Applicant: Bristol-Myers Squibb Company

Inventor： Dalton King ,  Lorin A. Thompson, III ,  Jianliang Shi ,  Srinivasan Thangathirupathy ,  Jayakumar Sankara Warrier ,  Imadul Islam ,  John E. Macor

IPC: A61K31/454 ,  C07D403/04 ,  C07D401/04

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

公开(公告)号：US20150094309A1

公开(公告)日：2015-04-02

申请号：US14574653

申请日：2014-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James H. Cook, II ,  Ivar M. McDonald ,  Dalton King ,  Richard E. Olson ,  Nenghui Wang ,  Christiana I. Iwuagwu ,  F. Christopher Zusi ,  John E. Macor

IPC: C07D519/00

CPC classification number: A61K31/506 ,  A61K31/439 ,  C07D498/20 ,  C07D519/00

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

Abstract translation: 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。