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公开(公告)号：US11304798B2
公开(公告)日：2022-04-19
申请号：US16413104
申请日：2019-05-15
发明人： David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, Jr. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
摘要： A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
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公开(公告)号：US10443107B2
公开(公告)日：2019-10-15
申请号：US16044845
申请日：2018-07-25
发明人： Crystal Marie Anderson-Cunanan , Daniel J. Foster , Ray McCarthy , Mary M. Byron , David Robert Wulfman , Bradley S. Swehla
摘要： A tissue modification apparatus includes at least a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue. The plurality of grippers are each secured to a first force actuator. The first plurality of grippers are each adapted to pivot relative to the first force actuator about an axis perpendicular to the plane. In some cases, a plurality of grippers are attached to a force actuator by a passive force transfer mechanism. In some cases, individual force actuators are attached by pivoted connections to individual grippers. Methods of treating tissue can secure tensioned tissue to a frame to retain the tension during a treatment (e.g., cross-linking the tissue with a chemical cross-linker).
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公开(公告)号：US10959869B2
公开(公告)日：2021-03-30
申请号：US16007170
申请日：2018-06-13
发明人： David Robert Wulfman , Matthew Nelson Frost , Pieter Spitael , Thomas Martin Keating , Martyn G. Folan , Martin Hynes , Christopher Brian Rognrud , Matthew Boyer
摘要： An example introducer is disclosed. An example introducer sheath includes a tubular member including a first layer and a second layer and a stent disposed between the first layer and the second layer of the tubular member. The stent includes an outer surface and an inner surface. Additionally, the stent is configured to shift from a first configuration to a second expanded configuration and the outer surface of the stent contacts the first layer of the tubular member in the second expanded configuration.
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公开(公告)号：US20200000476A1
公开(公告)日：2020-01-02
申请号：US16454698
申请日：2019-06-27
发明人： John D. Kroeger , David Robert Wulfman , Hoi Ki Ricky Chow , Adeniyi O. Aremu , Timothy A. Ostroot , Nicholas Lee Tassoni , Daniel K. Tomaschko , David Pettijohn
IPC分类号： A61B17/12
摘要： A vascular occlusion device for deployment within a lumen of a vessel may include a self-expanding frame configured to shift between a collapsed configuration and an expanded configuration, the self-expanding frame defining a perimeter of an interior space disposed within the self-expanding frame, and an occlusive membrane secured to the self-expanding frame. The occlusive membrane may include a suspended portion disposed within the self-expanding frame and spaced apart from the perimeter of the interior space.
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公开(公告)号：US20180353312A1
公开(公告)日：2018-12-13
申请号：US16007170
申请日：2018-06-13
发明人： David Robert Wulfman , Matthew Nelson Frost , Pieter Spitael , Thomas Martin Keating , Martyn G. Folan , Martin Hynes , Christopher Brian Rognrud , Matthew Boyer
CPC分类号： A61F2/966 , A61F2/86 , A61F2210/0004 , A61F2210/0014 , A61F2250/0098 , A61M25/0662 , A61M2025/0024
摘要： An example introducer is disclosed. An example introducer sheath includes a tubular member including a first layer and a second layer and a stent disposed between the first layer and the second layer of the tubular member. The stent includes an outer surface and an inner surface. Additionally, the stent is configured to shift from a first configuration to a second expanded configuration and the outer surface of the stent contacts the first layer of the tubular member in the second expanded configuration.
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公开(公告)号：US10080820B2
公开(公告)日：2018-09-25
申请号：US15250382
申请日：2016-08-29
发明人： Crystal Marie Anderson-Cunanan , Daniel J. Foster , Ray McCarthy , Mary M. Byron , David Robert Wulfman , Bradley S. Swehla
CPC分类号： C14B1/00 , A61F2/2415 , A61L27/3625 , A61L27/3687 , A61L27/3691 , A61L2430/20 , A61L2430/40 , C14B1/26 , C14B17/08 , D02J1/227
摘要： A tissue modification apparatus includes at least a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue. The plurality of grippers are each secured to a first force actuator. The first plurality of grippers are each adapted to pivot relative to the first force actuator about an axis perpendicular to the plane. In some cases, a plurality of grippers are attached to a force actuator by a passive force transfer mechanism. In some cases, individual force actuators are attached by pivoted connections to individual grippers. Methods of treating tissue can secure tensioned tissue to a frame to retain the tension during a treatment (e.g., cross-linking the tissue with a chemical cross-linker).
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公开(公告)号：US12115275B2
公开(公告)日：2024-10-15
申请号：US17179971
申请日：2021-02-19
发明人： Joseph Thomas Delaney, Jr. , Patrick Willoughby , David Robert Wulfman , Andrew J. Ro , Niraj Gurung
CPC分类号： A61L27/16 , A61L27/48 , C08J3/246 , C08L53/00 , D01D5/0023 , D01D5/003 , D01D5/0985 , A61L2430/20 , C08J2323/18 , C08J2323/22 , C08J2337/00 , C08J2479/02 , C08L2203/02 , D10B2509/06 , A61L27/48 , C08L23/22
摘要： Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
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公开(公告)号：US20240148487A1
公开(公告)日：2024-05-09
申请号：US18501832
申请日：2023-11-03
发明人： Mark Phillip Olson , Raymond David Gessler, III , Matthew Maciej , Nathan Stenger , Danielle Frankson , David Robert Wulfman , Kurt Nicholas Robakiewicz , Ryan V. Wales
IPC分类号： A61F2/04
CPC分类号： A61F2/04 , A61F2002/0081
摘要： Stents and/or endoluminal implants for extending across two non-adherent structures/tissues. An illustrative stent may comprise an elongated tubular body having a scaffolding forming a plurality of cells and a coating disposed over an outer surface of the elongated tubular body. The coating may comprise a first micro-porous layer and a macro-porous layer including a plurality of loops disposed over the micro-porous layer.
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公开(公告)号：US20160361047A1
公开(公告)日：2016-12-15
申请号：US15175672
申请日：2016-06-07
发明人： James P. ROHL , Katharine Eckerline , Bruce R. Forsyth , Charles Rundquist , David Robert Wulfman , Jason Ott , David John Lehse
CPC分类号： A61B10/04 , A61B10/0283 , A61B2010/045 , A61B2017/00862 , A61B2562/12 , A61L31/022 , A61M1/0056
摘要： A needle device for obtaining a tissue sample includes a distal member extending longitudinally from a proximal end to a distal end and including a distal channel extending longitudinally therethrough, the distal member formed of a first material selected to permit flexing of the distal member, a proximal member extending longitudinally from a proximal end to a distal end and including a proximal channel extending longitudinally therethrough, the proximal member formed of a second material selected to provide axial and torsional strength therealong in combination with a coupler for connecting the distal member and the proximal member, the coupler extending longitudinally from a proximal end configured to engage the distal end of the proximal member to a distal end configured to engage the proximal end of the distal member.
摘要翻译： 用于获得组织样本的针装置包括从近端到远端纵向延伸的远端构件，并且包括纵向延伸穿过其中的远端通道，所述远端构件由选择为允许远端构件弯曲的第一材料形成， 构件，其从近端纵向延伸到远端，并且包括纵向延伸穿过其中的近侧通道，所述近端构件由第二材料形成，所述近侧构件被选择成与用于连接远端构件和近端构件的联接器一起提供轴向和扭转强度 ，所述联接器从近端延伸，所述近端被构造成接合所述近端构件的远端到构造为接合所述远端构件的近端的远端。
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公开(公告)号：US20220296396A1
公开(公告)日：2022-09-22
申请号：US17700310
申请日：2022-03-21
摘要： A medical device that includes a body and a polymer matrix over the body. The polymer matrix includes a plurality of fibers defining a plurality of pores to permit tissue growth therethrough. The medical device includes a bio-adhesive coating at least partially covering the polymer matrix.
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