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公开(公告)号：US09109008B2
公开(公告)日：2015-08-18
申请号：US14177498
申请日：2014-02-11
Applicant: Bristol-Myers Squibb Company
Inventor： Qiang Cong , Heng Cheng , Sanjeev Gangwar
CPC classification number: C07K5/1024 , A61K38/05 , A61K38/07 , A61K47/48246 , A61K47/48415 , A61K47/48569 , A61K47/48592 , A61K47/48607 , A61K47/48615 , A61K47/48638 , A61K47/6811 , A61K47/6851 , A61K47/6857 , A61K47/6861 , A61K47/6863 , A61K47/6869 , C07K5/06 , C07K5/06139 , C07K5/06165 , C07K5/10 , C07K5/1016 , C07K7/06
Abstract: Tubulysin compounds of the formula (I) where R1, R2R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
Abstract translation: 其中R 1，R 2 R 3 a，R 3b，R 4，R 5，W和n如本文所定义的式（I）的调蛋白素化合物是可用于治疗癌症的抗有丝分裂剂，特别是当与靶向部分缀合时 。
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公开(公告)号：US20150132324A1
公开(公告)日：2015-05-14
申请号：US14605549
申请日：2015-01-26
Applicant: Bristol-Myers Squibb Company
Inventor： Qiang CONG , Heng Cheng , Sanjeev Gangwar
CPC classification number: C07K5/1024 , A61K38/05 , A61K38/07 , A61K47/48246 , A61K47/48415 , A61K47/48569 , A61K47/48592 , A61K47/48607 , A61K47/48615 , A61K47/48638 , A61K47/6811 , A61K47/6851 , A61K47/6857 , A61K47/6861 , A61K47/6863 , A61K47/6869 , C07K5/06 , C07K5/06139 , C07K5/06165 , C07K5/10 , C07K5/1016 , C07K7/06
Abstract: Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
Abstract translation: 其中R 1，R 2，R 3a，R 3b，R 4，R 5，W和n如本文所定义的式（I）的调节素化合物是可用于治疗癌症的抗有丝分裂剂，特别是当与 靶向部分。
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公开(公告)号：US10077287B2
公开(公告)日：2018-09-18
申请号：US14833422
申请日：2015-08-24
Applicant: Bristol-Myers Squibb Company
Inventor： Heidi L. Perez , Donna Wei , Robert M. Borzilleri , Sanjeev Gangwar , Gretchen M. Schroeder , Heng Cheng , Robert J. Schmidt
CPC classification number: C07K5/06139 , A61K47/6803 , A61K47/6813 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K5/06026 , C07K5/06034 , C07K5/06052 , C07K16/3038 , C07K16/3046
Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
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公开(公告)号：US08980824B2
公开(公告)日：2015-03-17
申请号：US14177376
申请日：2014-02-11
Applicant: Bristol-Myers Squibb Company
Inventor： Qiang Cong , Heng Cheng , Sanjeev Gangwar
IPC: A61K38/00 , A61K39/00 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K5/117 , A61K47/48 , C07K7/06 , C07K5/06 , C07K5/078
CPC classification number: C07K5/1024 , A61K38/05 , A61K38/07 , A61K47/48246 , A61K47/48415 , A61K47/48569 , A61K47/48592 , A61K47/48607 , A61K47/48615 , A61K47/48638 , A61K47/6811 , A61K47/6851 , A61K47/6857 , A61K47/6861 , A61K47/6863 , A61K47/6869 , C07K5/06 , C07K5/06139 , C07K5/06165 , C07K5/10 , C07K5/1016 , C07K7/06
Abstract: Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
Abstract translation: 其中R 1，R 2，R 3a，R 3b，R 4，R 5，W和n如本文所定义的式（I）的调节素化合物是可用于治疗癌症的抗有丝分裂剂，特别是当与 靶向部分。
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Patent Agency Ranking
公开(公告)号：US20140227295A1
公开(公告)日：2014-08-14
申请号：US14177376
申请日：2014-02-11
Applicant: Bristol-Myers Squibb Company
Inventor： Qiang CONG , Heng Cheng , Sanjeev Gangwar
CPC classification number: C07K5/1024 , A61K38/05 , A61K38/07 , A61K47/48246 , A61K47/48415 , A61K47/48569 , A61K47/48592 , A61K47/48607 , A61K47/48615 , A61K47/48638 , A61K47/6811 , A61K47/6851 , A61K47/6857 , A61K47/6861 , A61K47/6863 , A61K47/6869 , C07K5/06 , C07K5/06139 , C07K5/06165 , C07K5/10 , C07K5/1016 , C07K7/06
Abstract: Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
Abstract translation: 其中R 1，R 2，R 3a，R 3b，R 4，R 5，W和n如本文所定义的式（I）的调节素化合物是可用于治疗癌症的抗有丝分裂剂，特别是当与 靶向部分。
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公开(公告)号：US10398783B2
公开(公告)日：2019-09-03
申请号：US15789027
申请日：2017-10-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ivar M. McDonald , Prasanna Sivaprakasam , Christiana I. Iwuagwu , Kevin M. Peese , Heng Cheng , Naidu S. Chowdari , Sanjeev Gangwar
IPC: C07D471/04 , A61K47/68 , C07D519/00 , C07F7/08 , C07K5/062
Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
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公开(公告)号：US09688721B2
公开(公告)日：2017-06-27
申请号：US15171592
申请日：2016-06-02
Applicant: Bristol-Myers Squibb Company
Inventor： Qiang Cong , Heng Cheng , Sanjeev Gangwar
IPC: A61K38/00 , C07K5/117 , A61K47/48 , C07K7/06 , C07K5/10 , A61K38/07 , C07K5/06 , C07K5/078 , A61K38/05 , C07K5/107
CPC classification number: C07K5/1024 , A61K38/05 , A61K38/07 , A61K47/48246 , A61K47/48415 , A61K47/48569 , A61K47/48592 , A61K47/48607 , A61K47/48615 , A61K47/48638 , A61K47/6811 , A61K47/6851 , A61K47/6857 , A61K47/6861 , A61K47/6863 , A61K47/6869 , C07K5/06 , C07K5/06139 , C07K5/06165 , C07K5/10 , C07K5/1016 , C07K7/06
Abstract: Tubulysin compounds of the formula (I) where R1, R2 R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
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公开(公告)号：US20160264624A1
公开(公告)日：2016-09-15
申请号：US15171592
申请日：2016-06-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Qiang CONG , Heng Cheng , Sanjeev Gangwar
IPC: C07K5/117
CPC classification number: C07K5/1024 , A61K38/05 , A61K38/07 , A61K47/48246 , A61K47/48415 , A61K47/48569 , A61K47/48592 , A61K47/48607 , A61K47/48615 , A61K47/48638 , A61K47/6811 , A61K47/6851 , A61K47/6857 , A61K47/6861 , A61K47/6863 , A61K47/6869 , C07K5/06 , C07K5/06139 , C07K5/06165 , C07K5/10 , C07K5/1016 , C07K7/06
Abstract: Tubulysin compounds of the formula (I) where R1, R2 R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
Abstract translation: 其中R1，R2 R3a，R3b，R4，R5，W和n如本文所定义，是可用于治疗癌症的抗有丝分裂剂，特别是当与靶向部分缀合时。
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公开(公告)号：US09382289B2
公开(公告)日：2016-07-05
申请号：US14605549
申请日：2015-01-26
Applicant: Bristol-Myers Squibb Company
Inventor： Qiang Cong , Heng Cheng , Sanjeev Gangwar
IPC: A61K38/00 , C07K5/117 , A61K47/48 , C07K7/06 , C07K5/10 , A61K38/07 , C07K5/06 , C07K5/078 , A61K38/05 , C07K5/107
CPC classification number: C07K5/1024 , A61K38/05 , A61K38/07 , A61K47/48246 , A61K47/48415 , A61K47/48569 , A61K47/48592 , A61K47/48607 , A61K47/48615 , A61K47/48638 , A61K47/6811 , A61K47/6851 , A61K47/6857 , A61K47/6861 , A61K47/6863 , A61K47/6869 , C07K5/06 , C07K5/06139 , C07K5/06165 , C07K5/10 , C07K5/1016 , C07K7/06
Abstract: Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
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