公开(公告)号：US10077287B2

公开(公告)日：2018-09-18

申请号：US14833422

申请日：2015-08-24

Applicant: Bristol-Myers Squibb Company

Inventor： Heidi L. Perez ,  Donna Wei ,  Robert M. Borzilleri ,  Sanjeev Gangwar ,  Gretchen M. Schroeder ,  Heng Cheng ,  Robert J. Schmidt

IPC: A61K47/65 ,  A61K38/07 ,  C07K5/10 ,  C07K5/078 ,  C07K5/062 ,  A61K47/48 ,  C07K16/30

CPC classification number: C07K5/06139 ,  A61K47/6803 ,  A61K47/6813 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6889 ,  C07K5/06026 ,  C07K5/06034 ,  C07K5/06052 ,  C07K16/3038 ,  C07K16/3046

Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.