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Patent Agency Ranking
公开(公告)号：US09902740B2
公开(公告)日：2018-02-27
申请号：US15606512
申请日：2017-05-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong Zhang , Robert M. Borzilleri , Andrew J. Tebben , Erik M. Stang , Andrew F. Donnell , Gretchen M. Schroeder , Heidi L. Perez , Donna D. Wei
IPC: C07D519/00 , C07D498/22 , A61K47/48 , C07K16/30 , A61K31/5513 , A61K31/5517
CPC classification number: C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
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公开(公告)号：US10450318B2
公开(公告)日：2019-10-22
申请号：US15776936
申请日：2016-12-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gretchen M. Schroeder , Tram N. Huynh , Heidi L. Perez
IPC: C07D487/04 , A61P35/00 , C07D519/00
Abstract: The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications.
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公开(公告)号：US20180327409A1
公开(公告)日：2018-11-15
申请号：US15776936
申请日：2016-12-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gretchen M. Schroeder , Tram N. Huynh , Heidi L. Perez
IPC: C07D487/04 , C07D519/00 , A61P35/00
CPC classification number: C07D487/04 , A61P35/00 , C07D519/00
Abstract: The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications. (I)
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公开(公告)号：US10077287B2
公开(公告)日：2018-09-18
申请号：US14833422
申请日：2015-08-24
Applicant: Bristol-Myers Squibb Company
Inventor： Heidi L. Perez , Donna Wei , Robert M. Borzilleri , Sanjeev Gangwar , Gretchen M. Schroeder , Heng Cheng , Robert J. Schmidt
CPC classification number: C07K5/06139 , A61K47/6803 , A61K47/6813 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K5/06026 , C07K5/06034 , C07K5/06052 , C07K16/3038 , C07K16/3046
Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
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公开(公告)号：US09688694B2
公开(公告)日：2017-06-27
申请号：US15189388
申请日：2016-06-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong Zhang , Robert M. Borzilleri , Andrew J. Tebben , Erik M. Stang , Andrew F. Donnell , Gretchen M. Schroeder , Heidi L. Perez , Donna D. Wei
IPC: C07D487/04 , C07D519/00 , C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48 , C07K16/30
CPC classification number: C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
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