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公开(公告)号：US09902740B2
公开(公告)日：2018-02-27
申请号：US15606512
申请日：2017-05-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong Zhang , Robert M. Borzilleri , Andrew J. Tebben , Erik M. Stang , Andrew F. Donnell , Gretchen M. Schroeder , Heidi L. Perez , Donna D. Wei
IPC: C07D519/00 , C07D498/22 , A61K47/48 , C07K16/30 , A61K31/5513 , A61K31/5517
CPC classification number: C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
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公开(公告)号：US09453048B2
公开(公告)日：2016-09-27
申请号：US14419975
申请日：2013-08-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. Borzilleri , Heidi L. Perez , Donna D. Wei , Kyoung S. Kim
IPC: A61K38/06 , C07K5/09 , C07D401/12 , C07D207/16 , C07K5/062 , C07K5/083 , A61K45/06
CPC classification number: C07K5/0815 , A61K38/06 , A61K45/06 , C07D207/16 , C07D401/12 , C07K5/06026 , C07K5/0806
Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing said compounds.
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公开(公告)号：US20130338081A1
公开(公告)日：2013-12-19
申请号：US13921467
申请日：2013-06-19
Applicant: Bristol-Myers Squibb Company
Inventor： Robert M. Borzilleri , Heidi L. Perez , Erik M. Stang , Kyoung S. Kim
CPC classification number: A61K38/08 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/14 , C07K7/02
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US10450318B2
公开(公告)日：2019-10-22
申请号：US15776936
申请日：2016-12-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gretchen M. Schroeder , Tram N. Huynh , Heidi L. Perez
IPC: C07D487/04 , A61P35/00 , C07D519/00
Abstract: The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications.
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公开(公告)号：US08889712B2
公开(公告)日：2014-11-18
申请号：US13921467
申请日：2013-06-19
Applicant: Bristol-Myers Squibb Company
Inventor： Robert M. Borzilleri , Heidi L. Perez , Erik M. Stang , Kyoung S. Kim
IPC: A61K31/47 , C07D401/12 , C07D401/14 , C07K7/02 , A61K38/08 , C07D413/14 , A61K45/06 , C07D401/04
CPC classification number: A61K38/08 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/14 , C07K7/02
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
Abstract translation: 公开了利用本发明化合物调节凋亡抑制剂（IAP）的活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病和失调性细胞凋亡障碍的疾病的方法。
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Patent Agency Ranking
公开(公告)号：US09688694B2
公开(公告)日：2017-06-27
申请号：US15189388
申请日：2016-06-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong Zhang , Robert M. Borzilleri , Andrew J. Tebben , Erik M. Stang , Andrew F. Donnell , Gretchen M. Schroeder , Heidi L. Perez , Donna D. Wei
IPC: C07D487/04 , C07D519/00 , C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48 , C07K16/30
CPC classification number: C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
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公开(公告)号：US20180327409A1
公开(公告)日：2018-11-15
申请号：US15776936
申请日：2016-12-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gretchen M. Schroeder , Tram N. Huynh , Heidi L. Perez
IPC: C07D487/04 , C07D519/00 , A61P35/00
CPC classification number: C07D487/04 , A61P35/00 , C07D519/00
Abstract: The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications. (I)
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公开(公告)号：US10077287B2
公开(公告)日：2018-09-18
申请号：US14833422
申请日：2015-08-24
Applicant: Bristol-Myers Squibb Company
Inventor： Heidi L. Perez , Donna Wei , Robert M. Borzilleri , Sanjeev Gangwar , Gretchen M. Schroeder , Heng Cheng , Robert J. Schmidt
CPC classification number: C07K5/06139 , A61K47/6803 , A61K47/6813 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K5/06026 , C07K5/06034 , C07K5/06052 , C07K16/3038 , C07K16/3046
Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
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公开(公告)号：US09783573B2
公开(公告)日：2017-10-10
申请号：US14428688
申请日：2013-09-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. Borzilleri , Kyoung S. Kim , Heidi L. Perez , Erik M. Stang , David K. Williams , Liping Zhang
IPC: C07K5/08 , C07K5/083 , A61K38/06 , A61K45/06 , C07D401/14 , C07D413/14 , C07D401/06 , C07D401/10 , C07D401/12 , C07D417/14 , C07D487/04
CPC classification number: C07K5/0806 , A61K38/06 , A61K45/06 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US20150322111A1
公开(公告)日：2015-11-12
申请号：US14428688
申请日：2013-09-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. Borzilleri , Kyoung S. Kim , Heidi L. Perez , Erik M. Stang , David K. Williams , Liping Zhang
CPC classification number: C07K5/0806 , A61K38/06 , A61K45/06 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
Abstract translation: 公开了利用本发明化合物调节凋亡抑制剂（IAP）的活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病的方法和失调性细胞凋亡障碍（例如癌症）的化合物。
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