公开(公告)号：US20060043282A1

公开(公告)日：2006-03-02

申请号：US10927874

申请日：2004-08-27

申请人： August Hidalgo ,  Stuart Hansen ,  Gangqiang Li

发明人： August Hidalgo ,  Stuart Hansen ,  Gangqiang Li

IPC分类号： H01J49/00

CPC分类号： H01J49/401 ,  H01J49/422 ,  H01J49/424

摘要： An apparatus for analyzing ions is described. The apparatus includes an ion source, an ion trap positioned to receive ions from the ion source; a time of flight mass analyzer, and a detector operatively coupled to the time of flight. The time of flight mass analyzer includes a pulser region, and the pulser region is positioned to receive ions from the ion trap. The apparatus further includes a scanning delay timing circuit in operable relation to the pulser region. The scanning delay timing circuit is adapted to triggering an extraction pulse at the pulser region. Methods of analyzing ions by mass spectrometry are also described.

摘要翻译： 描述了用于分析离子的装置。 该装置包括离子源，定位成从离子源接收离子的离子阱; 飞行时间质量分析器，以及可操作地耦合到飞行时间的检测器。 飞行时间质量分析器包括脉冲发生器区域，并且脉冲发生器区域被定位成从离子阱接收离子。 该装置还包括与脉冲发生器区域可操作的扫描延迟定时电路。 扫描延迟定时电路适于在脉冲发生器区域触发提取脉冲。 还描述了通过质谱分析离子的方法。

公开(公告)号：US07208726B2

公开(公告)日：2007-04-24

申请号：US10927874

申请日：2004-08-27

申请人： August Hidalgo ,  Stuart C. Hansen ,  Gangqiang Li

发明人： August Hidalgo ,  Stuart C. Hansen ,  Gangqiang Li

IPC分类号： H01J49/00 ,  H01J49/40

CPC分类号： H01J49/401 ,  H01J49/422 ,  H01J49/424

摘要： An apparatus for analyzing ions is described. The apparatus includes an ion source, an ion trap positioned to receive ions from the ion source; a time of flight mass analyzer, and a detector operatively coupled to the time of flight. The time of flight mass analyzer includes a pulser region, and the pulser region is positioned to receive ions from the ion trap. The apparatus further includes a scanning delay timing circuit in operable relation to the pulser region. The scanning delay timing circuit is adapted to triggering an extraction pulse at the pulser region. Methods of analyzing ions by mass spectrometry are also described.

摘要翻译： 描述了用于分析离子的装置。 该装置包括离子源，定位成从离子源接收离子的离子阱; 飞行时间质量分析器，以及可操作地耦合到飞行时间的检测器。 飞行时间质量分析器包括脉冲发生器区域，并且脉冲发生器区域被定位成从离子阱接收离子。 该装置还包括与脉冲发生器区域可操作的扫描延迟定时电路。 扫描延迟定时电路适于在脉冲发生器区域触发提取脉冲。 还描述了通过质谱分析离子的方法。

公开(公告)号：US20070057180A1

公开(公告)日：2007-03-15

申请号：US11224093

申请日：2005-09-13

申请人： Stuart Hansen ,  Gangqiang Li ,  Gavin Reid

发明人： Stuart Hansen ,  Gangqiang Li ,  Gavin Reid

IPC分类号： H01J49/42

CPC分类号： H01J49/4225

摘要： A method and apparatus for processing ions in mass spectrometry is provided. The apparatus includes an ion processing cell having segmented multipole rods and a means for admitting reactive reagent ions to the cell. Provision for timed sequence control of RF and DC voltages to the segmented multipole rods is included. Processing includes trapping analyte ions and subjecting them to selected reactions with reactive reagent ions and/or physical manipulation of the ions by changing the characteristics of the electric field and/or creating discrete regions in the field.

摘要翻译： 提供了一种在质谱法中处理离子的方法和装置。 该装置包括具有分段多极棒的离子处理单元和用于将反应性试剂离子引入该单元的装置。 包括对分段多极杆的RF和DC电压的定时序列控制。 处理包括捕获分析物离子并使其与反应性试剂离子进行选择的反应和/或通过改变电场的特性和/或在场中产生离散区域来离子的物理操作。

公开(公告)号：US20070045531A1

公开(公告)日：2007-03-01

申请号：US11217248

申请日：2005-08-31

申请人： Alex Mordehai ,  Gangqiang Li ,  Stuart Hansen

发明人： Alex Mordehai ,  Gangqiang Li ,  Stuart Hansen

IPC分类号： H01J49/06

CPC分类号： H01J49/04 ,  H01J43/06 ,  H01J49/10

摘要： The invention provides a device for introducing ions into the primary ion path of a mass spectrometry system. In general, the device contains an electrical lens having a primary ion passageway and a secondary ion passageway that merges with the primary ion passageway. In certain embodiments, the electrical lens contains a first part and a second part that, together, form the primary ion passageway. The first part of the lens may contain the secondary ion passageway.

摘要翻译： 本发明提供了一种用于将离子引入质谱系统的一次离子路径的装置。 通常，该装置包含具有主离子通道和与主离子通道并入的次级离子通道的电透镜。 在某些实施例中，电透镜包含一起形成主离子通道的第一部分和第二部分。 透镜的第一部分可以包含二次离子通道。

公开(公告)号：US07642508B2

公开(公告)日：2010-01-05

申请号：US11680577

申请日：2007-02-28

申请人： Gangqiang Li

发明人： Gangqiang Li

IPC分类号： H01J49/00 ,  B01D59/44

CPC分类号： G01N30/7266 ,  B01L3/0268 ,  B01L3/5027 ,  B01L2300/0887 ,  B01L2400/0415 ,  B05B5/03 ,  H01J49/165

摘要： In accordance with the invention, auxiliary structures are used in conjunction with a microfluidic chip to form a microfluidic electrospray structure that allows gas assisted nebulization for use in a mass spectrometry system.

摘要翻译： 根据本发明，辅助结构与微流体芯片结合使用以形成允许气体辅助雾化用于质谱系统的微流体电喷雾结构。

公开(公告)号：US20060289741A1

公开(公告)日：2006-12-28

申请号：US11151875

申请日：2005-06-13

申请人： Gangqiang Li

发明人： Gangqiang Li

IPC分类号： H01J49/00

CPC分类号： H01J49/107 ,  H01J49/0045 ,  H01J49/04

摘要： The invention provides an apparatus for combining ions and charged particles. In general, the apparatus contains: a) a multipole device having an ion exit end; b) a mass analyzer; and c) a source of charged particles. The apparatus is configured so that charged particles produced by the source of charged particles pass through the mass analyzer and into the multipole device via the ion exit end of the multipole device.

摘要翻译： 本发明提供了一种用于组合离子和带电粒子的装置。 通常，该装置包含：a）具有离子出口端的多极装置; b）质量分析仪; 和c）带电粒子源。 该装置被配置为使得由带电粒子源产生的带电粒子经由质量分析器通过多极装置的离子出口端进入多极装置。

公开(公告)号：US06639217B1

公开(公告)日：2003-10-28

申请号：US10324423

申请日：2002-12-20

申请人： Gangqiang Li

发明人： Gangqiang Li

IPC分类号： H01J5944

CPC分类号： H01J49/164

摘要： Mass spectrometry systems and methods are disclosed. Briefly described, one embodiment of the mass spectrometry system, among others, includes a mass spectrometer, a laser generator, and a sample substrate. The mass spectrometer includes a first end and a second end and the laser generator produces a laser radiation beam that travels along a first path. The sample substrate holds a sample at the first end of the mass spectrometer, where the sample produces a plurality of ions that travel along a second path that is substantially parallel the first path but towards the second end of the mass spectrometer.

摘要翻译： 公开了质谱系统和方法。 简而言之，质谱系统的一个实施方案包括质谱仪，激光发生器和样品基片。 质谱仪包括第一端和第二端，激光发生器产生沿着第一路径行进的激光辐射束。 样品基板在质谱仪的第一端保持样品，其中样品产生沿着基本上平行于第一路径但朝向质谱仪的第二端行进的第二路径行进的多个离子。

公开(公告)号：US06593570B2

公开(公告)日：2003-07-15

申请号：US09747242

申请日：2000-12-22

申请人： Gangqiang Li ,  Charles W. Russ, IV

发明人： Gangqiang Li ,  Charles W. Russ, IV

IPC分类号： H01J4900

CPC分类号： H01J49/062

摘要： Apparatus and methods are disclosed for manipulating charged particles. The charged particles are directed from a source thereof into a zone. A first electrical potential is generated in the zone. Simultaneously, a second electrical potential is generated outside the zone. The second electrical potential penetrates into the zone and combines with the first electrical potential to form an oscillating electric potential field having predetermined characteristics sufficient to manipulate the charged particles. The manipulating of the charged particles includes, e.g., transporting, collisional cooling, collisional induced dissociating and collisional focusing. In one embodiment an apparatus comprises a hollow first element and a hollow second element. The second element is disposed within the first element. The second element has at least two openings in a wall thereof. The openings are elongated and radially disposed with respect to the axis of the second element. The length of the openings is at least about 20% of the length of the second element The first element and the second element each are adapted independently to receive a voltage to generate within the second element an electric potential having predetermined characteristics. The apparatus and methods of the invention have particular application to the field of mass spectrometry.

摘要翻译： 公开了用于操纵带电粒子的装置和方法。 带电粒子从其来源导入区域。 在该区域中产生第一电位。 同时，在区域外产生第二电位。 第二电位渗入该区并与第一电位组合以形成具有足以操纵带电粒子的预定特性的振荡电势场。 带电粒子的操纵包括例如运输，碰撞冷却，碰撞诱导的解离和碰撞聚焦。 在一个实施例中，一种装置包括中空的第一元件和中空的第二元件。 第二元件设置在第一元件内。 第二元件在其壁中具有至少两个开口。 开口是细长的并且相对于第二元件的轴线径向设置。 开口的长度为第二元件的长度的至少约20％。第一元件和第二元件各自独立地适应于接收在第二元件内产生具有预定特征的电位的电压。 本发明的装置和方法特别适用于质谱领域。

公开(公告)号：US08642951B2

公开(公告)日：2014-02-04

申请号：US13101008

申请日：2011-05-04

申请人： Gangqiang Li

发明人： Gangqiang Li

IPC分类号： H01J49/40

CPC分类号： H01J49/405 ,  H01J3/16

摘要： Devices and systems for reflecting ions are provided. In general, the devices and systems include a plurality of curved lens plates adapted for connection to at least one voltage source and having a passage therein to allow the ions to pass therethrough. The plurality of curved lens plates generates electric fields having elliptic equipotential surfaces that reflect and focus the ions as they pass through the passage. Reflectron time-of-flight (RE-TOF) spectrometers are also provided that include an ion source, ion detector, and such a reflectron as described above. Mass spectrometer systems are provided that comprise an ion source that generates ions and a reflectron TOF spectrometer such as described above.

摘要翻译： 提供了用于反射离子的装置和系统。 通常，装置和系统包括适于连接至少一个电压源的多个弯曲透镜板，并且其中具有允许离子通过的通道。 多个弯曲透镜板产生具有椭圆等电位面的电场，它们在通过通道时反射和聚焦离子。 还提供了反射器飞行时间（RE-TOF）光谱仪，其包括如上所述的离子源，离子检测器和反射器。 提供包括产生离子的离子源和如上所述的反射体TOF光谱仪的质谱仪系统。

公开(公告)号：US07619213B2

公开(公告)日：2009-11-17

申请号：US11499177

申请日：2006-08-03

申请人： Gangqiang Li

发明人： Gangqiang Li

IPC分类号： H01J49/40

CPC分类号： H01J49/061

摘要： The invention provides an ion extraction pulser. The ion extraction pulser may be used independently or in conjunction with a mass spectrometry system. The mass spectrometry system includes an ion source for producing ions, an ion optics system downstream from the ion source for selecting and directing ions, and a detector down stream from the ion optics system for detecting the ions selected and directed by the ion optics system. The ion optics system includes one or more ion extraction pulsers. The ion extraction pulser includes a mesh plate for applying a pulse for extracting ions from an ion beam; a first filter plate adjacent to the mesh plate for filtering ions extracted by the mesh plate; a guard plate adjacent to the first filter plate for further directing ions filtered by the first filter plate; and a second filter plate adjacent to the first guard plate for further filtering ions directed from the guard plateThe invention also provides methods for extracting, selecting and processing ions using ion extraction pulsers.

摘要翻译： 本发明提供一种离子提取脉冲发生器。 离子提取脉冲发生器可以独立使用或与质谱系统结合使用。 质谱系统包括用于产生离子的离子源，用于选择和引导离子的离子源下游的离子光学系统，以及用于检测由离子光学系统选择和引导的离子的离子光学系统的下游检测器。 离子光学系统包括一个或多个离子提取脉冲发生器。 离子提取脉冲发生器包括用于从离子束中提取离子的脉冲的网板; 与网板相邻的第一过滤板，用于过滤由网板提取的离子; 与所述第一过滤板相邻的防护板，用于进一步引导由所述第一过滤板过滤的离子; 以及与第一防护板相邻的第二过滤板，用于进一步过滤从防护板引导的离子。 本发明还提供了使用离子萃取脉冲发生器提取，选择和处理离子的方法。