公开(公告)号：US20060208187A1

公开(公告)日：2006-09-21

申请号：US11084830

申请日：2005-03-18

Applicant: Alex Mordehai ,  Bryan Miller

Inventor： Alex Mordehai ,  Bryan Miller

IPC: H01J49/42

CPC classification number: H01J49/4225 ,  H01J49/004

Abstract: The present invention relates to an apparatus and method for providing improved sensitivity and duty cycle in a mass spectrometry system. The mass spectrometry system of the present invention includes an ionization source, a mass analyzer/filter and an ion detector. The mass analyzer has a first trapping section, a second trapping section and a gating section interposed between the first trapping section and the second trapping section. The device may further include one or more lenses adjacent to the gating or trapping sections. The invention also provides an ion trap. The ion trap of the present invention has a first trapping section, a second trapping section and a gating section interposed between the first trapping section and the second trapping section. The gating and trapping sections may be in a linear arrangement. A method regarding the application of the present invention is also described. For instance, the method of the present invention includes ionizing a sample, trapping ions in a trapping section, selecting ions using a gating section and trapping ions in a second trapping section.

Abstract translation: 本发明涉及一种用于在质谱系统中提供改进的灵敏度和占空比的装置和方法。 本发明的质谱系统包括电离源，质量分析器/过滤器和离子检测器。 质量分析器具有第一捕集部分，第二捕获部分和插入在第一捕集部分和第二捕集部分之间的选通部分。 该装置还可以包括与门控或捕获部分相邻的一个或多个透镜。 本发明还提供一种离子阱。 本发明的离子阱具有第一捕获部，第二捕获部和插入在第一捕集部和第二捕获部之间的选通部。 选通和捕获部分可以是线性排列。 还描述了关于本发明的应用的方法。 例如，本发明的方法包括使样品离子化，捕获捕获部分中的离子，使用选通部分选择离子并在第二捕获部分捕获离子。

公开(公告)号：US20050194529A1

公开(公告)日：2005-09-08

申请号：US11116800

申请日：2005-04-27

Applicant: Alex Mordehai

Inventor： Alex Mordehai

IPC: H01J49/42 ,  B01D59/44

CPC classification number: H01J49/063 ,  H01J49/004 ,  H01J49/061 ,  H01J49/40

Abstract: Apparatus for delivering ions to a mass analyzer. The apparatus includes a time of flight ion guide, a pulsing device for receiving a continuous ion stream containing ions of different atomic mass and for delivering pulses of ions to the ion guide wherein ions in each of the pulses of ions exit the ion guide in ascending order of their atomic mass, and a gating device at the exit end of the ion guide for allowing ions of a predetermined atomic mass to pass to the mass analyzer.

公开(公告)号：US5352892A

公开(公告)日：1994-10-04

申请号：US9063

申请日：1993-01-26

Applicant: Alex Mordehai ,  Gerard Hopfgartner ,  John D. Henion

Inventor： Alex Mordehai ,  Gerard Hopfgartner ,  John D. Henion

IPC: G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/067 ,  G01N30/7266 ,  H01J49/044 ,  G01N30/7246 ,  G01N30/7273

Abstract: A novel atmospheric pressure ionization device for the transport of charged particle produced by at atmospheric pressure to a mass analyzer includes a liquid shield between the particle source and the sample inlet into the mass analyzer. The liquid shield may be in the form of a disk with a central aperture and acts as a spray splitter and aerofocusing device which increases the flow rate of a liquid sample into the analyzer. The mass analyzer is located in a high vacuum region and an intermediate low vacuum region is provided between the sample inlet and the analyzer. An ion optical system includes electrostatic lens assemblies in said vacuum regions for transporting charged particles from the inlet to the analyzer.

Abstract translation: 用于将通过大气压产生的带电粒子输送到质量分析器的新型大气压电离装置包括在粒子源和质量分析器的样品入口之间的液体屏蔽。 液体屏蔽可以是具有中心孔的盘的形式，并且用作喷雾分离器和空气聚焦装置，其将液体样品的流速增加到分析器中。 质量分析仪位于高真空区域，并且在样品入口和分析仪之间提供中间低真空区域。 离子光学系统包括在所述真空区域中的静电透镜组件，用于将带电粒子从入口传送到分析器。

公开(公告)号：US5650617A

公开(公告)日：1997-07-22

申请号：US688469

申请日：1996-07-30

Applicant: Alex Mordehai

Inventor： Alex Mordehai

IPC: H01J49/34 ,  H01J49/38 ,  H01J49/42

CPC classification number: H01J49/4295 ,  H01J49/38

Abstract: A method and mass spectrometer system for trapping ions within an ion trap by increasing the flight path of ions therein. An ion beam is produced by external ion source and is directed to the ion trap which comprises at least one trapping electrode in proximity to an exit region of the ion beam from the ion trap. A retarding DC voltage is applied to the trapping electrode during ion accumulation time for creating a fringing reflection field and for retaining ions within the ion trap.

Abstract translation: 一种通过增加其中离子的飞行路径来捕获离子阱内的离子的方法和质谱仪系统。 离子束由外部离子源产生，并被引导到离子阱，该离子阱包括至少一个捕获电极，离离子阱离子束的出口区域附近。 在离子积聚时间期间，向捕获电极施加延迟DC电压，以产生边缘反射场并将离子保持在离子阱内。

公开(公告)号：US20070205360A1

公开(公告)日：2007-09-06

申请号：US11676698

申请日：2007-02-20

Applicant: Alex Mordehai

Inventor： Alex Mordehai

IPC: H01J49/40

CPC classification number: H01J49/063 ,  H01J49/004 ,  H01J49/061 ,  H01J49/40

Abstract: Apparatus for delivering ions to the mass analyzer. The apparatus includes a time of flight ion guide, a pulsing device for receiving a continuous ion stream containing ions of different atomic mass and for delivering pulses of ions to the ion guide wherein ions in each of the pulses of ions exit the ion guide in ascending order of their atomic mass, and a gating device at the exit end of the ion guide for allowing ions of a predetermined atomic mass to pass to the mass analyzer.

Abstract translation: 用于将离子输送到质量分析仪的装置。 所述装置包括飞行时间离子引导件，用于接收含有不同原子质量的离子的连续离子流的脉冲装置，用于将离子脉冲输送到离子导向器，其中每个离子脉冲中的离子以升序离开离子导向器 以及在离子导向件的出口端的选通装置，用于允许预定原子质量的离子通过质量分析器。

公开(公告)号：US20070045531A1

公开(公告)日：2007-03-01

申请号：US11217248

申请日：2005-08-31

Applicant: Alex Mordehai ,  Gangqiang Li ,  Stuart Hansen

Inventor： Alex Mordehai ,  Gangqiang Li ,  Stuart Hansen

IPC: H01J49/06

CPC classification number: H01J49/04 ,  H01J43/06 ,  H01J49/10

Abstract: The invention provides a device for introducing ions into the primary ion path of a mass spectrometry system. In general, the device contains an electrical lens having a primary ion passageway and a secondary ion passageway that merges with the primary ion passageway. In certain embodiments, the electrical lens contains a first part and a second part that, together, form the primary ion passageway. The first part of the lens may contain the secondary ion passageway.

Abstract translation: 本发明提供了一种用于将离子引入质谱系统的一次离子路径的装置。 通常，该装置包含具有主离子通道和与主离子通道并入的次级离子通道的电透镜。 在某些实施例中，电透镜包含一起形成主离子通道的第一部分和第二部分。 透镜的第一部分可以包含二次离子通道。

公开(公告)号：US5729014A

公开(公告)日：1998-03-17

申请号：US678742

申请日：1996-07-11

Applicant: Alex Mordehai ,  Sidney E. Buttrill, Jr.

Inventor： Alex Mordehai ,  Sidney E. Buttrill, Jr.

IPC: H01J49/26 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/4295 ,  H01J49/424

Abstract: A method of ion collection over a wide mass-to-charge range from continuous ion source into a quadrupole ion trap filled with a buffer gas directing an ion beam, from an external ion source to a radio frequency ion trap through a gating device for a predetermined period of accumulation time to allow the beam to enter the trap, trapping ions over a range of masses by applying a radio frequency voltage to the trap and changing an amplitude of the radio frequency voltage adiabatically to achieve a uniform trapping efficiency for ions over a predetermined mass range. The predetermined period of accumulation time may be divided into a plurality of segments, and the amplitude of the radio-frequency voltage is changing adiabatically within each segment.

Abstract translation: 一种在从连续离子源到充满缓冲气体的四极离子阱的宽质量 - 电荷范围内的离子收集方法，该缓冲气体从外部离子源到射频离子阱通过选通装置引导离子束 预定的累积时间，以允许光束进入陷阱，通过向陷阱施加射频电压而在一定范围的质量范围内捕获离子，并绝热地改变射频电压的振幅，以实现离子超过一定的捕获效率 预定质量范围。 累积时间的预定周期可以被划分成多个段，并且射频电压的幅度在每个段内都是绝热的。

公开(公告)号：US20080197275A1

公开(公告)日：2008-08-21

申请号：US11676249

申请日：2007-02-16

Applicant: Alex Mordehai ,  Craig P. Love ,  Mark H. Werlich

Inventor： Alex Mordehai ,  Craig P. Love ,  Mark H. Werlich

IPC: B01D59/44 ,  H01J27/00

CPC classification number: H01J49/10 ,  H01J49/0095 ,  H01J49/0404

Abstract: The present invention provides ion sampling apparatuses that can be used in a fast polarity-switching electric field. In some embodiments, the ion sampling apparatus comprises a capillary made with an insulator, with a resistive inner or outer surface. Devices and systems comprising the ion sampling apparatuses, as well as methods of use thereof, are also provided.

Abstract translation: 本发明提供了可用于快速极性切换电场的离子采样装置。 在一些实施例中，离子采样设备包括由绝缘体制成的毛细管，其具有电阻内表面或外表面。 还提供了包括离子取样装置的装置和系统及其使用方法。

公开(公告)号：US07183542B2

公开(公告)日：2007-02-27

申请号：US11116800

申请日：2005-04-27

Applicant: Alex Mordehai

Inventor： Alex Mordehai

IPC: B01D59/44

CPC classification number: H01J49/063 ,  H01J49/004 ,  H01J49/061 ,  H01J49/40

Abstract: Apparatus for delivering ions to a mass analyzer. The apparatus includes a time of flight ion guide, a pulsing device for receiving a continuous ion stream containing ions of different atomic mass and for delivering pulses of ions to the ion guide wherein ions in each of the pulses of ions exit the ion guide in ascending order of their atomic mass, and a gating device at the exit end of the ion guide for allowing ions of a predetermined atomic mass to pass to the mass analyzer.

Abstract translation: 用于将离子输送到质量分析器的装置。 所述装置包括飞行时间离子引导件，用于接收含有不同原子质量的离子的连续离子流的脉冲装置，用于将离子脉冲输送到离子导向器，其中每个离子脉冲中的离子以升序离开离子导向器 以及在离子导向件的出口端的选通装置，用于允许预定原子质量的离子通过质量分析器。

公开(公告)号：US5268572A

公开(公告)日：1993-12-07

申请号：US948394

申请日：1992-09-23

Applicant: Alex Mordehai ,  John D. Henion

Inventor： Alex Mordehai ,  John D. Henion

IPC: H01J49/24 ,  H01J49/42

CPC classification number: H01J49/426 ,  H01J49/24

Abstract: An ion trap mass spectrometer includes an ion trap region separated from an electron multiplier region by a baffle, and separate turbomolecular pumps for pumping each region to a different pressure level. The ion trap region can therefore be pumped to a higher pressure level than ca be used for the electron multiplier region, and the result and increase in pressure of damping gas in the ion trap region increases the sensitivity of the device.

Abstract translation: 离子阱质谱仪包括通过挡板与电子倍增器区域分离的离子阱区域，以及用于将每个区域泵送到不同压力水平的单独的涡轮分子泵。 因此，离子阱区域可以泵送到比用于电子倍增器区域的更高的压力水平，并且离子阱区域中的阻尼气体的结果和压力的增加增加了装置的灵敏度。