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公开(公告)号：US20240066041A1
公开(公告)日：2024-02-29
申请号：US18284283
申请日：2022-03-28
发明人： Sinead Bleiel
IPC分类号： A61K31/00 , A23D9/007 , A23D9/05 , A23G3/40 , A23G3/42 , A23G3/48 , A23L2/52 , A23L29/30 , A23L33/105 , A23L33/115 , A61K9/00 , A61K9/107 , A61K9/16 , A61K9/48 , A61K36/185
CPC分类号： A61K31/658 , A23D9/007 , A23D9/05 , A23G3/40 , A23G3/42 , A23G3/48 , A23L2/52 , A23L29/35 , A23L33/105 , A23L33/115 , A61K9/0095 , A61K9/1075 , A61K9/1652 , A61K9/1664 , A61K9/1694 , A61K9/4808 , A61K36/185
摘要： Food, beverage and nutritional supplements containing microparticles containing stabilised CBD oil, and methods for the production thereof” Food, beverage and nutritional supplements that containing microparticles are described. The microparticles contain CBD oil stabilized in an acacia or inulin fibre or cyclodextrin matrix. Methods for the production of the compositions comprise making the microparticles by providing an oil-in-water microemulsion comprising CBD oil, water, acacia/inulin fibre and optionally maltodextrin or cyclodextrin, and freeze-drying the microemulsion to remove water and provide a preparation of dried microparticles. The dried microparticles comprise a dispersed phase of stabilized microdroplets of CBD oil disposed in a continuous solid matrix comprising acacia or inulin fibre. The preparation of microcapsules contains less than 10% free CBD oil and exhibit improved pharmacokinetics and bioavailability of CD.
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公开(公告)号：US10898442B2
公开(公告)日：2021-01-26
申请号：US15564635
申请日：2016-06-02
发明人： Sinead Bleiel
IPC分类号： A61K9/51 , A61K9/50 , A23P10/35 , A23P30/25 , A23L27/00 , A23L29/275 , A23L33/12 , A23P10/30 , A23L33/115 , A61K9/107 , A61K35/612 , A61K47/44
摘要： The invention provides a gelated mono-nuclear microencapsulate comprising a lipid emulsion core encapsulated within a gastro-resistant, ileal sensitive, polymerized chitosan membrane shell, wherein the lipid emulsion core comprises denatured or hydrolysed protein and carbohydrate. In one embodiment of the invention, the emulsion is a micro-emulsion, and typically comprises a surfactant and a co-surfactant or at least two carbohydrates, for example sucrose and a maltodextrin. In one embodiment of the invention, the lipid is a marine derived lipid such as fish oil, krill oil, or nutraceutical fatty acids. In other embodiment, the lipid is a fatty acid such as DHA or ARA, or a lipid derived from seeds, nuts or eggs.
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3.发明申请公开(公告)号：US20180084819A1
公开(公告)日：2018-03-29
申请号：US15564632
申请日：2016-05-23
IPC分类号： A23P10/40 , A23L29/238 , A23L29/256 , A23L33/185 , A23L33/19 , C08J3/12
CPC分类号： A23P10/40 , A23L29/20 , A23L29/238 , A23L29/256 , A23L33/185 , A23L33/19 , A23V2002/00 , A23V2200/228 , A23V2250/282 , A23V2250/5036 , A23V2250/506 , A24F47/008 , A61M11/042 , A61M15/06 , C08J3/122 , C08J2389/00 , H01M10/0525 , H01M10/42 , H02J7/345
摘要： A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5-15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce micro-particles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.
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公开(公告)号：US11103550B2
公开(公告)日：2021-08-31
申请号：US15536298
申请日：2015-12-15
发明人： Sinead Bleiel
IPC分类号： A61K38/17 , A61K35/20 , A23P10/30 , A23L33/10 , A61K36/48 , A61K31/7016 , A61P3/10 , A61K9/50 , A61K38/16 , A23L33/185 , A23L33/19 , A23L2/52 , A61K9/00
摘要： A cold-gelated mono-nuclear microencapsulate comprises a unitary liquid core encapsulated within a gastro-resistant, ileal-sensitive, polymerized denatured protein membrane shell, wherein the liquid core comprises a GLP-1 release stimulating agent in a substantially solubilised form. The GLP-1 release stimulating agent is a native protein selected from native dairy protein, native vegetable protein or native egg protein.
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公开(公告)号：US11576416B2
公开(公告)日：2023-02-14
申请号：US16441841
申请日：2019-06-14
IPC分类号： A23P10/40 , C08J3/12 , A23L33/185 , A23L33/19 , A23L29/238 , A23L29/256 , H01M10/42 , A23L29/20 , H02J7/34 , A61M15/06 , A61M11/04 , H01M10/0525
摘要： A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5-15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce microparticles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.
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6.发明申请公开(公告)号：US20190289896A1
公开(公告)日：2019-09-26
申请号：US16441841
申请日：2019-06-14
IPC分类号： A23P10/40 , A23L29/256 , A23L29/238 , C08J3/12 , A23L33/185 , A23L33/19 , A24F47/00 , H01M10/42 , H02J7/34 , A23L29/20
摘要： A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5-15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce microparticles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.
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公开(公告)号：US20180071224A1
公开(公告)日：2018-03-15
申请号：US15564635
申请日：2016-06-02
发明人： Sinead Bleiel
IPC分类号： A61K9/50 , A61K9/107 , A61K35/612 , A61K47/44 , A23P10/35 , A23P30/25 , A23L27/00 , A23L29/275 , A23L33/12
CPC分类号： A61K9/5036 , A23L27/72 , A23L29/275 , A23L33/115 , A23L33/12 , A23P10/30 , A23P10/35 , A23P30/25 , A23V2002/00 , A23V2250/1862 , A23V2250/1868 , A23V2250/511 , A23V2250/5114 , A23V2250/616 , A23V2250/628 , A61K9/1075 , A61K35/612 , A61K47/44
摘要： The invention provides a gelated mono-nuclear microencapsulate comprising a lipid emulsion core encapsulated within a gastro-resistant, ileal sensitive, polymerized chitosan membrane shell, wherein the lipid emulsion core comprises denatured or hydrolysed protein and carbohydrate. In one embodiment of the invention, the emulsion is a micro-emulsion, and typically comprises a surfactant and a co-surfactant or at least two carbohydrates, for example sucrose and a maltodextrin. In one embodiment of the invention, the lipid is a marine derived lipid such as fish oil, krill oil, or nutraceutical fatty acids. In other embodiment, the lipid is a fatty acid such as DHA or ARA, or a lipid derived from seeds, nuts or eggs.
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