-
1.
公开(公告)号:US20180084819A1
公开(公告)日:2018-03-29
申请号:US15564632
申请日:2016-05-23
IPC分类号: A23P10/40 , A23L29/238 , A23L29/256 , A23L33/185 , A23L33/19 , C08J3/12
CPC分类号: A23P10/40 , A23L29/20 , A23L29/238 , A23L29/256 , A23L33/185 , A23L33/19 , A23V2002/00 , A23V2200/228 , A23V2250/282 , A23V2250/5036 , A23V2250/506 , A24F47/008 , A61M11/042 , A61M15/06 , C08J3/122 , C08J2389/00 , H01M10/0525 , H01M10/42 , H02J7/345
摘要: A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5-15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce micro-particles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.
-
公开(公告)号:US11576416B2
公开(公告)日:2023-02-14
申请号:US16441841
申请日:2019-06-14
IPC分类号: A23P10/40 , C08J3/12 , A23L33/185 , A23L33/19 , A23L29/238 , A23L29/256 , H01M10/42 , A23L29/20 , H02J7/34 , A61M15/06 , A61M11/04 , H01M10/0525
摘要: A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5-15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce microparticles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.
-
3.
公开(公告)号:US20190289896A1
公开(公告)日:2019-09-26
申请号:US16441841
申请日:2019-06-14
IPC分类号: A23P10/40 , A23L29/256 , A23L29/238 , C08J3/12 , A23L33/185 , A23L33/19 , A24F47/00 , H01M10/42 , H02J7/34 , A23L29/20
摘要: A method of producing microparticles by spray drying comprises the steps of providing a spray-drying feedstock solution comprising water, a volatile divalent metal salt, weak acid, 5-15% dairy or vegetable protein (w/v) and 1-20% active agent (w/v). The feedstock solution is adjusted to have a pH at which the volatile divalent metal salt is substantially insoluble. The feedstock solution is then spray-dried at an elevated temperature to provide atomised droplets, whereby the volatile divalent metal salt disassociates at the elevated temperature to release divalent metal ions which crosslink and aggregate the protein in the atomised droplets to produce microparticles having a crosslinked aggregated protein matrix and active agent dispersed throughout the matrix.
-
-