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公开(公告)号：US20240018556A1
公开(公告)日：2024-01-18
申请号：US18353673
申请日：2023-07-17
发明人： Jeffrey George LINGER , Christine Ann SINGER , Lauren Ann Riley DRUMM , Michael T. GUARNIERI , Davinia SALVACHÚA RODRÍGUEZ , Colin Matthew KNEUCKER , Violeta SANCHEZ NOGUE
CPC分类号： C12P7/52 , C12N9/88 , C12Y401/01018 , C12N9/0014 , C12Y104/99
摘要： Clostridium sp. are an obligate anaerobic bacterium that produces butyric acid as its major end-product. Previously, we have developed an integrated process that couples fermentation of biomass sugars, with in situ product recovery and distillation. This process works best at pH's lower than 7.0. The process serves to extract carboxylic acids during fermentation which enables reduced base-loading and reduced end-product toxicity. Disclosed herein are methods and non-naturally Clostridium sp. that are capable of increased production of butyric acid and increased growth at low pH conditions (e.g., pH
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公开(公告)号：US20230357704A1
公开(公告)日：2023-11-09
申请号：US18311875
申请日：2023-05-03
摘要： Disclosed herein are compositions and methods for biological upgrading of electrocatalysis-derived formate presents a promising approach to sequester CO2, valorize curtailed electrons, and establish a sustainable formate bioeconomy.
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公开(公告)号：US20220251500A1
公开(公告)日：2022-08-11
申请号：US17666345
申请日：2022-02-07
IPC分类号： C12N1/12 , C07K14/435
摘要： Disclosed herein are methods and compositions for implementing a photosynthetic protein secretion platform.
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公开(公告)号：US20220356495A1
公开(公告)日：2022-11-10
申请号：US17657902
申请日：2022-04-04
发明人： Michael T. GUARNIERI , Rabea JESSER
摘要： Disclosed herein are methods and compositions of matter that enable the biological conversion of gaseous waste streams (CO2, stranded natural gas, flue gas, biogas, landfill gas, etc.) to a platform chemical, 3-hydroxybutyrate, which can in turn be upgraded to fuels and polymers (e.g. polypropylene and polymers). The technology thus presents both a mechanism to valorize gaseous waste streams and establish sustainable production routes to chemicals and plastics via the overexpression of PHB depolymerase while knocking out the AACS pathway in this specific strain of methanotrophic bacteria.
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公开(公告)号：US20180371502A1
公开(公告)日：2018-12-27
申请号：US14563299
申请日：2014-12-08
发明人： Gregg T. BECKHAM , Jeffrey G. LINGER , Derek R. VARDON , Michael T. GUARNIERI , Eric M. KARP , Mary Ann FRANDEN , Christopher W. JOHNSON , Timothy J. STRATHMANN , Philip T. PIENKOS
摘要： Disclosed herein are methods for the production of fuels, chemicals, or materials from biomass-derived lignin, cellulose, and hemicellulose. Also provided are methods for the production of polyhydroxyalkanoates from lignocellulosic biomass and the subsequent thermal and catalytic conversion of polyhydroxyalkanoates to hydrocarbons. In addition, methods for the production of ethanol from the fermentation of polysaccharides are described.
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公开(公告)号：US20170088866A1
公开(公告)日：2017-03-30
申请号：US15282591
申请日：2016-09-30
发明人： Eric P. KNOSHAUG , Min ZHANG , Arjun SINGH , Michael T. GUARNIERI
CPC分类号： C12P7/6436 , C07K14/395 , C12N9/0006 , C12N9/1029 , C12N9/12 , C12N9/1205 , C12P7/10 , C12Y101/01009 , C12Y101/01307 , C12Y203/0102 , C12Y207/01017 , C12Y207/11001 , Y02E50/16 , Y02E50/17
摘要： Presented herein are oleaginous strains of yeast such as Saccharomyces cerevisiae that have been modified to allow for xylose utilization. Such strains are also modified to allow for higher lipid accumulation utilizing a broad range of sugar monomers such as those released during pretreatment and enzymatic saccharification of lignocellulosic biomass. Methods of producing lipids and ethanol using these yeast strains are also disclosed.
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公开(公告)号：US20170058280A1
公开(公告)日：2017-03-02
申请号：US15252648
申请日：2016-08-31
CPC分类号： C12N15/52 , C12N9/0069 , C12N9/1022 , C12N9/1294 , C12N9/88 , C12P7/44 , C12Y113/11001 , C12Y202/01001 , C12Y207/09002 , C12Y401/01059 , C12Y401/01063 , C12Y401/02009 , C12Y402/01118
摘要： Presented herein are biocatalysts and methods for converting C1-containing materials to organic acids such as muconic acid or adipic acid.
摘要翻译： 本文提出的是将含C1材料转化为有机酸如粘酸或己二酸的生物催化剂和方法。
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公开(公告)号：US20230110210A1
公开(公告)日：2023-04-13
申请号：US17951848
申请日：2022-09-23
摘要： Phosphite dehydrogenase (ptxD) expression was established as a selectable marker for nuclear and chloroplast genetic selection in Picochlorum renovo and Picochlorum celeri Phosphite was used as a sole phosphorus source in P. renovo and P. celeri. Growth on phosphite led to comparable growth and composition relative to phosphate.
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公开(公告)号：US20210071187A1
公开(公告)日：2021-03-11
申请号：US16989549
申请日：2020-08-10
摘要： Disclosed herein are a suite of genetic tools suitable for engineering both the nucleus and chloroplast in diverse microalgae.
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公开(公告)号：US20200071704A1
公开(公告)日：2020-03-05
申请号：US16548971
申请日：2019-08-23
摘要： Presented herein are biocatalysts and methods for converting C1-containing materials to organic acids such as muconic acid or adipic acid.
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