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    PRODRUGS AND COMPOSITIONS FOR OPHTHALMOLOGY APPLICATIONS
    2.
    发明公开
    PRODRUGS AND COMPOSITIONS FOR OPHTHALMOLOGY APPLICATIONS 审中-公开

    公开(公告)号：US20240166691A1

    公开(公告)日：2024-05-23

    申请号：US18503390

    申请日：2023-11-07

    申请人： Alcon Inc.

    发明人： Howard Allen Ketelson ,  Rekha Rangarajan

    IPC分类号： C07K7/64

    CPC分类号： C07K7/645

    摘要： The present disclosure is directed to prodrugs, compositions including prodrugs, and methods for administering prodrugs and compositions thereof to a patient, including prodrugs represented by Formula (I):




    wherein: D is a drug moiety; Q is an oxygen atom, a sulfur atom, or a nitrogen atom; X is a chemical bond or




    each of G, G′, and G″ is independently an oxygen atom or a sulfur atom; L is a polyether; T is a hydrogen atom, a hydroxyl group, a thiol group, a boronic acid group, or an amine group; R1 is selected from the group consisting of a substituted aryl group, unsubstituted aryl group, and a substituted carbonyl group; and each of R2, R3, R1′, R2′, R3′, and R4′ is independently a hydrogen atom, a substituted C1-C20 alkyl group, or an unsubstituted C1 -C20 alkyl group. In at least one embodiment, a composition comprises a compound and a carrier material.

    DISSOLVABLE MEDICAL DEVICE AND KIT FOR CORNEAL SURFACE PROTECTION
    3.
    发明公开
    DISSOLVABLE MEDICAL DEVICE AND KIT FOR CORNEAL SURFACE PROTECTION 审中-公开

    公开(公告)号：US20230201112A1

    公开(公告)日：2023-06-29

    申请号：US18145256

    申请日：2022-12-22

    申请人： Alcon Inc.

    发明人： Howard Allen Ketelson ,  Rekha Rangarajan ,  Patrick John Sadd

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/36 ,  A61K47/32 ,  A61K47/10

    CPC分类号： A61K9/0051 ,  A61K9/70 ,  A61K47/36 ,  A61K47/32 ,  A61K47/10

    摘要： A dissolvable medical device for protecting a corneal surface and providing lubrication and hydration to the corneal surface during ophthalmic surgery comprising: a polymeric film has sufficient dimensions to substantially cover a cornea when applied to an eye, wherein the polymeric film comprising one or more mucoadhesive polymers. The polymeric film dissolves between 15 minutes to 120 minutes to release the mucoadhesive polymers after applying the polymeric film to the eye and the polymeric film provides more effective corneal surface protection relative to a saline treatment based on Mean Green Fluorescence Index test (demonstrates corneal damage) during a simulated surgery. In addition, a kit for use in ophthalmic surgical procedures comprises 1) the at least one dissolvable medical device and 2) at least one viscosurgical viscoelastic or at least one ophthalmoscopic surgical contact lens.

    DISSOLVABLE POLYMERIC EYE INSERTS WITH A BIODEGRADABLE POLYMER AND METHOD OF USING THE SAME
    6.
    发明申请
    DISSOLVABLE POLYMERIC EYE INSERTS WITH A BIODEGRADABLE POLYMER AND METHOD OF USING THE SAME 有权

    公开(公告)号：US20220323346A1

    公开(公告)日：2022-10-13

    申请号：US17808342

    申请日：2022-06-23

    申请人： Alcon Inc.

    发明人： Howard Allen Ketelson ,  Rekha Rangarajan

    IPC分类号： A61K9/00 ,  A61K31/357 ,  A61K31/498 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36

    摘要： Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. These inserts may contain one or more mucoadhesive polymers polymers, a biodegradable polymer as well as softener/plasticizer so that, when inserted into the eye, they may absorb tears, and dissolve and slowly release lubricant into the tear film to lubricate and protect the ocular surface for an extended duration of time. The biodegradable polymer containing eye insert may increase dissolution time on the ocular surface for longer lasting relief, may reduce dosing frequency and patient burden typically associated with topical drop usage. These polymeric eye inserts also may include one or more pharmaceutically active agents.