公开(公告)号：US20170020906A1

公开(公告)日：2017-01-26

申请号：US15302793

申请日：2015-04-03

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  GERALYN DUSKA-MCEWEN ,  STEVEN DAVIS

IPC: A61K31/7016 ,  A23L33/00 ,  A23L2/52 ,  A61K31/702

Abstract: A method for enhancing an individual's mucosal innate immune response to pathogens is disclosed. The method includes a step of administering a nutritional composition to the individual. The nutritional composition includes about 0.05 to about 0.5 mg/mL 2′-fucosyllactose (2′-FL), about 0.05 to about 0.5 mg/mL lacto-N-neotetraose (LNnT), or a combination of both. Also disclosed is a method for enhancing an individual's mucosal innate immune detection of pathogens. The method includes a step of administering a nutritional composition to the individual. The nutritional composition includes a neutral human milk oligosaccharide.

Abstract translation: 公开了一种增强个体对病原体的粘膜先天免疫应答的方法。 该方法包括向个体施用营养组合物的步骤。 营养组合物包括约0.05至约0.5mg / mL的2'-岩藻糖基乳糖（2'-FL），约0.05至约0.5mg / mL乳-N-新四糖（LNnT）或两者的组合。 还公开了一种用于增强个体的病原体的粘膜先天免疫检测的方法。 该方法包括向个体施用营养组合物的步骤。 营养组合物包括中性人乳寡糖。

公开(公告)号：US20150140161A1

公开(公告)日：2015-05-21

申请号：US14515203

申请日：2014-10-15

Applicant: ABBOTT LABORATORIES

Inventor： CHRON-SI LAI ,  STEVEN DAVIS ,  KEITH GARLEB ,  JOHN LASEKAN

IPC: A23L1/29 ,  A23L1/30

CPC classification number: A61K31/05 ,  A23K20/158 ,  A23K50/30 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/00 ,  A61K31/20

Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Abstract translation: 公开了营养配方，其包括可以对早产儿，婴儿，幼儿和儿童施用的预消化脂肪，用于改善营养物质的耐受性，消化和吸收以及降低坏死性小肠结肠炎，绞痛和短肠综合征的发生率。 预先消化的脂肪包括含脂肪酸的单甘油酯和/或脂肪酸组分。

公开(公告)号：US20200206251A1

公开(公告)日：2020-07-02

申请号：US16730139

申请日：2019-12-30

Applicant: Abbott Laboratories

Inventor： RACHAEL BUCK ,  STEVEN DAVIS ,  PAUL FORSYTHE

IPC: A61K31/702 ,  A23L33/115 ,  A23L33/21 ,  A23L33/00 ,  A23L33/10 ,  A61K31/445 ,  A61K31/495 ,  A61K31/4545 ,  A61K31/7016 ,  A23L29/00 ,  A23L29/30 ,  A61K45/06 ,  A23L5/00 ,  A23L33/125

Abstract: A method for preventing or mitigating an acute allergic response in a subject is disclosed. The method includes a step of administering a nutritional composition to the subject. The nutritional composition includes at least one of an acidic or a neutral HMO, but does not include an N-acetyl-lactosamine.

公开(公告)号：US20160296544A1

公开(公告)日：2016-10-13

申请号：US15037743

申请日：2014-11-18

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  STEVEN DAVIS ,  PAUL FORSYTHE

IPC: A61K31/702 ,  A61K45/06

CPC classification number: A61K31/702 ,  A23L5/00 ,  A23L21/00 ,  A23L29/04 ,  A23L29/045 ,  A23L29/30 ,  A23L33/10 ,  A23L33/115 ,  A23L33/125 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2250/00 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/7016 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/18 ,  A23V2250/28 ,  A23V2250/50 ,  A23V2250/54 ,  A23V2250/60 ,  A23V2200/304

Abstract: A method for preventing or mitigating an acute allergic response in a subject is disclosed. The method includes a step of administering a nutritional composition to the subject. The nutritional composition includes at least one of an acidic or a neutral HMO, but does not include an N-acetyl-lactosamine.

Abstract translation: 公开了一种预防或减轻受试者急性过敏反应的方法。 该方法包括向受试者施用营养组合物的步骤。 营养组合物包括酸性或中性HMO中的至少一种，但不包括N-乙酰基 - 乳糖胺。