公开(公告)号：US20200230162A1

公开(公告)日：2020-07-23

申请号：US16838660

申请日：2020-04-02

Applicant: ABBOTT LABORATORIES

Inventor： GERALYN DUSKA-MCEWEN ,  SARAH COMSTOCK ,  SHARON DONOVAN ,  RACHAEL BUCK ,  JOSEPH SCHALLER

IPC: A61K31/7028 ,  A23L33/22 ,  A23L33/00 ,  A23L33/12 ,  A23L33/115 ,  A23L33/15 ,  A23L33/105 ,  A23L29/30 ,  A23L33/10 ,  A61K45/06 ,  A23L2/52 ,  A61K31/702 ,  A61K31/202 ,  A61K31/015 ,  A61K9/00 ,  A23L33/21 ,  A23L33/125 ,  A23L5/00

Abstract: Disclosed is a nutritional composition for use in modulating or reducing inflammation in an adult or elderly individual in need thereof. In some aspects, the nutritional composition comprises a neutral human milk oligosaccharide.

公开(公告)号：US20180161352A1

公开(公告)日：2018-06-14

申请号：US15892234

申请日：2018-02-08

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  GERALYN O. DUSKA-MCEWEN ,  JOSEPH P. SCHALLER

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/12 ,  A61K31/7016 ,  A61K31/202 ,  A61K45/06

CPC classification number: A61K31/702 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/3202 ,  A23V2200/324 ,  A23V2250/1882 ,  A23V2250/28 ,  A61K31/202 ,  A61K31/7016 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.

公开(公告)号：US20180133234A1

公开(公告)日：2018-05-17

申请号：US15818374

申请日：2017-11-20

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  GERALYN O. DUSKA-MCEWEN ,  JOSEPH P. SCHALLER

IPC: A61K31/702 ,  A23L33/00 ,  A61K45/06 ,  A61K31/202 ,  A61K31/7016 ,  A23L33/12

CPC classification number: A61K31/702 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/3202 ,  A23V2200/324 ,  A23V2250/1882 ,  A23V2250/28 ,  A61K31/202 ,  A61K31/7016 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.

公开(公告)号：US20180104267A1

公开(公告)日：2018-04-19

申请号：US15844294

申请日：2017-12-15

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  GERALYN O. DUSKA-MCEWEN ,  JOSEPH P. SCHALLER

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/12 ,  A61K31/7016 ,  A61K31/202 ,  A61K45/06

CPC classification number: A61K31/702 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/3202 ,  A23V2200/324 ,  A23V2250/1882 ,  A23V2250/28 ,  A61K31/202 ,  A61K31/7016 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.

公开(公告)号：US20230149434A1

公开(公告)日：2023-05-18

申请号：US18157545

申请日：2023-01-20

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  GERALYN O. DUSKA-MCEWEN ,  JOSEPH P. SCHALLER

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/12 ,  A61K31/202 ,  A61K31/7016 ,  A61K45/06

CPC classification number: A61K31/702 ,  A23L33/12 ,  A23L33/40 ,  A61K31/202 ,  A61K31/7016 ,  A61K45/06 ,  A23V2002/00 ,  A23V2200/324 ,  A23V2200/3202 ,  A23V2250/28 ,  A23V2250/1882 ,  A61K2300/00

Abstract: Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.

公开(公告)号：US20220354876A1

公开(公告)日：2022-11-10

申请号：US17750874

申请日：2022-05-23

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  JOMAY CHOW ,  STEVEN R. DAVIS

IPC: A61K31/702 ,  A23L33/00

Abstract: Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to individuals including preterm infants, infants, toddlers, and children for improving gastrointestinal function and tolerance, as well as the growth of beneficial bacteria. Additional suitable methods of using the nutritional compositions including the human milk oligosaccharides are also disclosed.

公开(公告)号：US20220117984A1

公开(公告)日：2022-04-21

申请号：US17562327

申请日：2021-12-27

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  GERALYN O. DUSKA-MCEWEN ,  STEVEN R. DAVIS

IPC: A61K31/702 ,  A23L33/00 ,  A61K31/716 ,  A23C9/20 ,  A61K31/05

Abstract: Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to preterm infants, term infants, toddlers, and children for improving airway defense mechanisms.

公开(公告)号：US20210228603A1

公开(公告)日：2021-07-29

申请号：US17228342

申请日：2021-04-12

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  GERALYN O. DUSKA-MCEWEN ,  JOSEPH P. SCHALLER

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/12 ,  A61K31/202 ,  A61K31/7016 ,  A61K45/06

Abstract: Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.

公开(公告)号：US20180042950A1

公开(公告)日：2018-02-15

申请号：US15791052

申请日：2017-10-23

Applicant: ABBOTT LABORATORIES

Inventor： STEVEN R. DAVIS ,  RACHAEL BUCK ,  GERALYN O. DUSKA-MCEWEN

IPC: A61K31/702 ,  A61K31/7016

CPC classification number: A61K31/702 ,  A61K31/7016

Abstract: Disclosed are methods of reducing the incidence of oxidative stress in infants, toddlers, and children using nutritional compositions including human milk oligosaccharides. The nutritional compositions including the human milk oligosaccharides are effective at reducing inflammation and the incidence of inflammatory diseases.

公开(公告)号：US20170020906A1

公开(公告)日：2017-01-26

申请号：US15302793

申请日：2015-04-03

Applicant: ABBOTT LABORATORIES

Inventor： RACHAEL BUCK ,  GERALYN DUSKA-MCEWEN ,  STEVEN DAVIS

IPC: A61K31/7016 ,  A23L33/00 ,  A23L2/52 ,  A61K31/702

Abstract: A method for enhancing an individual's mucosal innate immune response to pathogens is disclosed. The method includes a step of administering a nutritional composition to the individual. The nutritional composition includes about 0.05 to about 0.5 mg/mL 2′-fucosyllactose (2′-FL), about 0.05 to about 0.5 mg/mL lacto-N-neotetraose (LNnT), or a combination of both. Also disclosed is a method for enhancing an individual's mucosal innate immune detection of pathogens. The method includes a step of administering a nutritional composition to the individual. The nutritional composition includes a neutral human milk oligosaccharide.

Abstract translation: 公开了一种增强个体对病原体的粘膜先天免疫应答的方法。 该方法包括向个体施用营养组合物的步骤。 营养组合物包括约0.05至约0.5mg / mL的2'-岩藻糖基乳糖（2'-FL），约0.05至约0.5mg / mL乳-N-新四糖（LNnT）或两者的组合。 还公开了一种用于增强个体的病原体的粘膜先天免疫检测的方法。 该方法包括向个体施用营养组合物的步骤。 营养组合物包括中性人乳寡糖。