公开(公告)号：US20190014807A1

公开(公告)日：2019-01-17

申请号：US16066585

申请日：2016-12-27

Applicant: ABBOTT LABORATORIES

Inventor： TAPAS DAS ,  MUSTAFA VURMA ,  CHRON-SI LAI ,  PAUL JOHNS

IPC: A23L33/00 ,  A23L33/12 ,  A23L33/18 ,  A23L33/19 ,  A23L29/00 ,  A61K38/01 ,  A61P25/28

Abstract: Disclosed embodiments provide nutritional compositions and methods of enhancing maturation of an infant's brain. The methods include the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75% in combination with at least one of a monoglyceride, a free fatty acid, a salt of a free fatty acid, a phospholipid, and cholesterol.

公开(公告)号：US20170258759A1

公开(公告)日：2017-09-14

申请号：US15529305

申请日：2015-11-25

Applicant: ABBOTT LABORATORIES

Inventor： MATTHEW KUCHAN ,  CHRON-SI LAI ,  JACQUELINE BOFF

IPC: A61K31/355 ,  A23L33/12 ,  A61K31/047 ,  A23L33/00 ,  A61K31/015 ,  A23L33/155 ,  A23L33/15

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/155 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/01 ,  A61K31/015 ,  A61K31/047 ,  A61K31/065 ,  A61K31/122 ,  A61K2300/00

Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are also disclosed. Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.

公开(公告)号：US20140249224A1

公开(公告)日：2014-09-04

申请号：US14274133

申请日：2014-05-09

Applicant: ABBOTT LABORATORIES

Inventor： CHRON-SI LAI ,  KEITH A. GARLEB ,  JOHN B. LASEKAN ,  STEVEN R. DAVIS ,  CHRISTOPHER T. CORDLE ,  RUSSELL J. MERRITT

IPC: A61K31/20 ,  A61K31/05

CPC classification number: A61K31/05 ,  A23K20/158 ,  A23K50/30 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/00 ,  A61K31/20

Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Abstract translation: 公开了营养配方，其包括可以对早产儿，婴儿，幼儿和儿童施用的预消化脂肪，用于改善营养物质的耐受性，消化和吸收以及降低坏死性小肠结肠炎，绞痛和短肠综合征的发生率。 预先消化的脂肪包括含脂肪酸的单甘油酯和/或脂肪酸组分。

公开(公告)号：US20180256536A1

公开(公告)日：2018-09-13

申请号：US15977390

申请日：2018-05-11

Applicant: ABBOTT LABORATORIES

Inventor： MATTHEW KUCHAN ,  CHRON-SI LAI ,  JACQUELINE BOFF

IPC: A61K31/355 ,  A61K31/047 ,  A61K31/015 ,  A23L33/00 ,  A23L33/15 ,  A23L33/12 ,  A23L33/155

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/155 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/01 ,  A61K31/015 ,  A61K31/047 ,  A61K31/065 ,  A61K31/122 ,  A61K2300/00

Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.

公开(公告)号：US20180235930A1

公开(公告)日：2018-08-23

申请号：US15962545

申请日：2018-04-25

Applicant: ABBOTT LABORATORIES

Inventor： CHRON-SI LAI ,  MATTHEW KUCHAN

IPC: A61K31/355 ,  A23L33/00 ,  A61K31/202 ,  A23L33/12 ,  A61K9/00 ,  A23L33/15 ,  A61K47/22

Abstract: Disclosed are methods of using nutritional compositions generally, and infant formulas specifically, to improve cognitive, brain and/or central nervous system development in an individual. The nutritional compositions include a combination of RRR-alpha tocopherol acetate, non-RRR-alpha-tocopherol stereoisomers, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited.

公开(公告)号：US20220007704A1

公开(公告)日：2022-01-13

申请号：US17486328

申请日：2021-09-27

Applicant: ABBOTT LABORATORIES

Inventor： TAPAS DAS ,  MUSTAFA VURMA ,  CHRON-SI LAI ,  PAUL JOHNS

IPC: A23L33/00 ,  A61K38/01 ,  A23L33/12 ,  A23L33/19 ,  A23L33/18 ,  A23L33/115 ,  A61K45/06 ,  A23L29/00 ,  A61P25/28

Abstract: Disclosed embodiments provide nutritional compositions and methods of enhancing maturation of an infant's brain. The methods include the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75% in combination with at least one of a monoglyceride, a free fatty acid, a salt of a free fatty acid, a phospholipid, and cholesterol.

公开(公告)号：US20190000913A1

公开(公告)日：2019-01-03

申请号：US16066557

申请日：2016-12-27

Applicant: ABBOTT LABORATORIES

Inventor： TAPAS DAS ,  MUSTAFA VURMA ,  CHRON-SI LAI ,  PAUL JOHNS

IPC: A61K38/01 ,  A61P1/00 ,  A23L33/18 ,  A23L33/00 ,  A23L33/125

Abstract: Disclosed embodiments provide a method of enhancing maturation of a lung, brain, or both, in an infant. The method includes the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75%. Also disclosed are methods for reducing the incidence of necrotizing enterocolitis in an individual. In addition, the disclosed embodiments provide a method for the prevention, delay of progression, or the treatment of a circulatory disorder characterized by inadequate blood flow to the brain or lung.

公开(公告)号：US20150140161A1

公开(公告)日：2015-05-21

申请号：US14515203

申请日：2014-10-15

Applicant: ABBOTT LABORATORIES

Inventor： CHRON-SI LAI ,  STEVEN DAVIS ,  KEITH GARLEB ,  JOHN LASEKAN

IPC: A23L1/29 ,  A23L1/30

CPC classification number: A61K31/05 ,  A23K20/158 ,  A23K50/30 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/00 ,  A61K31/20

Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Abstract translation: 公开了营养配方，其包括可以对早产儿，婴儿，幼儿和儿童施用的预消化脂肪，用于改善营养物质的耐受性，消化和吸收以及降低坏死性小肠结肠炎，绞痛和短肠综合征的发生率。 预先消化的脂肪包括含脂肪酸的单甘油酯和/或脂肪酸组分。

公开(公告)号：US20220346429A1

公开(公告)日：2022-11-03

申请号：US17853515

申请日：2022-06-29

Applicant: ABBOTT LABORATORIES

Inventor： TAPAS DAS ,  MUSTAFA VURMA ,  CHRON-SI LAI ,  PAUL JOHNS

IPC: A23L33/00 ,  A61K38/01 ,  A23L33/12 ,  A23L33/19 ,  A23L33/18 ,  A23L33/115 ,  A61K45/06 ,  A23L29/00 ,  A61P25/28

Abstract: Disclosed embodiments provide nutritional compositions and methods of enhancing maturation of an infant's brain. The methods include the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75% in combination with at least one of a monoglyceride, a free fatty acid, a salt of a free fatty acid, a phospholipid, and cholesterol.

公开(公告)号：US20160279095A1

公开(公告)日：2016-09-29

申请号：US15036001

申请日：2014-11-12

Applicant: ABBOTT LABORATORIES

Inventor： REMA VAZHAPPILLY ,  CHRON-SI LAI ,  MATTHEW KUCHAN

IPC: A61K31/355 ,  A61K31/047 ,  A61K31/202

CPC classification number: A61K31/355 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/047 ,  A61K31/20 ,  A61K31/202

Abstract: Disclosed herein are nutritional compositions for pregnant or lactating mothers, pre-term and term infants, toddlers and children which include natural vitamin E, a long chain polyunsaturated fatty acid (LC-PUFA) and a carotenoid such as lutein. Also disclosed are methods of administering these compositions for reducing or preventing the susceptibility of the fetal and newborn brain and lungs to hypoxia and the resulting disorders resulting therefrom including abnormal cognitive development, brain in jury and lung injury.

Abstract translation: 本文公开了含有天然维生素E，长链多不饱和脂肪酸（LC-PUFA）和类胡萝卜素如叶黄素的怀孕或哺乳期母亲，早产儿和术前婴儿，幼儿和儿童的营养组合物。 还公开了施用这些组合物以减少或预防胎儿和新生儿脑和肺对缺氧的易感性的方法以及由此引起的由此产生的病症，包括异常认知发育，陪审团和肺损伤中的脑。