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公开(公告)号：US20140303122A1
公开(公告)日：2014-10-09
申请号：US14229152
申请日：2014-03-28
申请人： AJINOMOTO CO., INC.
发明人： Masayuki SUGIKI , Toru Okamatsu , Sayaka Asari , Yayoi Kawato , Toshihiro Hatanaka , Tetsuo Yano , Yukie Seki , Naohiro Miyamura , Hiroaki Nagasaki , Yuzuru Eto , Reiko Yasuda
IPC分类号： C07C237/04 , A23L1/226 , C07F9/38 , C07C309/51 , C07F9/40
CPC分类号： C07C237/04 , A23L27/204 , A23L27/22 , A23L33/175 , C07C309/51 , C07F9/3834 , C07F9/4018 , C07F9/4021
摘要： By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.
摘要翻译： 通过搜索具有CaSR激动活性的各种化合物，本发明提供了各自包含该化合物的CaSR激动剂，药物组合物，用于腹泻和赋形剂的预防或治疗剂。 更具体地，本发明提供了CaSR激动剂，药物组合物，用于腹泻和赋予Kokumi的预防或治疗剂，其各自包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐。
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公开(公告)号：US11680279B2
公开(公告)日：2023-06-20
申请号：US16200011
申请日：2018-11-26
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Rekha Murali , Sayaka Asari , Keita Fukui , Miku Toyazaki , Keiko Noguchi
IPC分类号： C12P13/12 , C12P7/24 , C12N9/10 , C12N9/06 , C12P7/42 , C12N1/20 , C12R1/15 , C12R1/19 , C12R1/46
CPC分类号： C12P7/24 , C12N1/205 , C12N9/0012 , C12N9/1014 , C12N9/1085 , C12P7/42 , C12P13/12 , C12R2001/15 , C12R2001/19 , C12R2001/46 , C12Y105/0102 , C12Y201/02002 , C12Y205/01006
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.
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公开(公告)号：US11053519B2
公开(公告)日：2021-07-06
申请号：US16392805
申请日：2019-04-24
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Peter Kelly , Sayaka Asari , Keita Fukui , Miku Toyazaki
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of S-adenosyl-L-homocysteine hydrolase is increased.
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公开(公告)号：US20190161776A1
公开(公告)日：2019-05-30
申请号：US16200011
申请日：2018-11-26
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Rekha Murali , Sayaka Asari , Keita Fukui , Miku Toyazaki , Keiko Noguchi
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.
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5.发明申请公开(公告)号：US20140329796A1
公开(公告)日：2014-11-06
申请号：US14332782
申请日：2014-07-16
申请人： Ajinomoto Co., Inc.
IPC分类号： C07D417/14 , C07D409/14 , C07D417/12 , C07D413/14
CPC分类号： C07D417/14 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12
摘要： The present invention aims to provide a novel compound having a TRPA1 antagonist activity, and a medicament containing the compound. Moreover, the present invention aims to provide a TRPA1 antagonist and a medicament useful for the prophylaxis or treatment of diseases involving TRPA1.A medicament containing a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译： 本发明旨在提供具有TRPA1拮抗剂活性的新化合物和含有该化合物的药物。 此外，本发明的目的是提供一种TRPA1拮抗剂和可用于预防或治疗涉及TRPA1的疾病的药物。 含有由式（I）表示的化合物的药物：其中每个符号如说明书中所定义，或其药学上可接受的盐等。
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公开(公告)号：US10858676B2
公开(公告)日：2020-12-08
申请号：US15982623
申请日：2018-05-17
申请人： AJINOMOTO CO., INC.
发明人： Christine Roche , Benjamin Mijts , Peter Kelly , Matthew Davis , Sayaka Asari , Keita Fukui , Miku Toyazaki
IPC分类号： C12P7/42 , C12P13/12 , C12R1/15 , C12R1/19 , C12N15/77 , C12N9/78 , C12N9/88 , C12N9/10 , C12P7/22 , C12P7/24
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.
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公开(公告)号：US20190241915A1
公开(公告)日：2019-08-08
申请号：US16392805
申请日：2019-04-24
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Peter Kelly , Sayaka Asari , Keita Fukui , Miya Toyazaki
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , A23L27/204 , A23L27/24 , C12N9/14 , C12P7/24 , C12P13/12 , C12Y303/01001
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of S-adenosyl-L-homocysteine hydrolase is increased.
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公开(公告)号：US20190249206A1
公开(公告)日：2019-08-15
申请号：US16392791
申请日：2019-04-24
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Sayaka Asari , Miku Toyazaki , Keita Fukui
CPC分类号： C12P7/24 , C12N1/36 , C12N2330/50 , C12N2510/02 , C12P7/42 , C12P13/12 , C12R1/15 , C12R1/19 , C12Y101/01001 , C12Y101/01025 , C12Y113/11003 , C12Y114/13082
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of enolase is reduced.
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公开(公告)号：US20180312881A1
公开(公告)日：2018-11-01
申请号：US16032206
申请日：2018-07-11
申请人： AJINOMOTO CO., INC.
发明人： Yasuaki Takakura , Keiko Danjo , Keita Fukui , Sayaka Asari , Takuto Ono
IPC分类号： C12P7/24
CPC分类号： C12P7/24 , C12Y101/99031 , C12Y104/03002 , C12Y113/11046 , C12Y401/01007
摘要： A method for producing benzaldehyde is provided. Benzaldehyde is produced from L-phenylalanine or a carbon source by using microorganism(s) having amino acid deaminase, 4-hydroxymandelate synthase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase.
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公开(公告)号：US09174932B2
公开(公告)日：2015-11-03
申请号：US14229152
申请日：2014-03-28
申请人： AJINOMOTO CO., INC.
发明人： Masayuki Sugiki , Toru Okamatsu , Sayaka Asari , Yayoi Kawato , Toshihiro Hatanaka , Tetsuo Yano , Yukie Seki , Naohiro Miyamura , Hiroaki Nagasaki , Yuzuru Eto , Reiko Yasuda
IPC分类号： C07C237/04 , C07C309/51 , C07F9/38 , A23L1/228 , A23L1/305 , C07F9/40 , A23L1/226
CPC分类号： C07C237/04 , A23L27/204 , A23L27/22 , A23L33/175 , C07C309/51 , C07F9/3834 , C07F9/4018 , C07F9/4021
摘要： By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.
摘要翻译： 通过搜索具有CaSR激动活性的各种化合物，本发明提供了各自包含该化合物的CaSR激动剂，药物组合物，用于腹泻和赋形剂的预防或治疗剂。 更具体地，本发明提供了CaSR激动剂，药物组合物，用于腹泻和赋予Kokumi的预防或治疗剂，其各自包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐。
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