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公开(公告)号：US20190249204A1
公开(公告)日：2019-08-15
申请号：US16392819
申请日：2019-04-24
申请人： AJINOMOTO CO., INC.
CPC分类号： C12P7/22 , C12N9/1007 , C12P7/24 , C12P7/42
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified to have a Bacteroidetes O-methyltransferase (OMT) gene, especially an OMT gene encoding OMT having a specific mutation.
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公开(公告)号：US10858676B2
公开(公告)日：2020-12-08
申请号：US15982623
申请日：2018-05-17
申请人： AJINOMOTO CO., INC.
发明人： Christine Roche , Benjamin Mijts , Peter Kelly , Matthew Davis , Sayaka Asari , Keita Fukui , Miku Toyazaki
IPC分类号： C12P7/42 , C12P13/12 , C12R1/15 , C12R1/19 , C12N15/77 , C12N9/78 , C12N9/88 , C12N9/10 , C12P7/22 , C12P7/24
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.
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公开(公告)号：US20190241915A1
公开(公告)日：2019-08-08
申请号：US16392805
申请日：2019-04-24
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Peter Kelly , Sayaka Asari , Keita Fukui , Miya Toyazaki
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , A23L27/204 , A23L27/24 , C12N9/14 , C12P7/24 , C12P13/12 , C12Y303/01001
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of S-adenosyl-L-homocysteine hydrolase is increased.
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公开(公告)号：US10883124B2
公开(公告)日：2021-01-05
申请号：US16392819
申请日：2019-04-24
申请人： AJINOMOTO CO., INC.
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified to have a Bacteroidetes O-methyltransferase (OMT) gene, especially an OMT gene encoding OMT having a specific mutation.
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公开(公告)号：US20190249205A1
公开(公告)日：2019-08-15
申请号：US16392756
申请日：2019-04-24
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Peter Kelly , Sayaka Asari , Keita Fukui , Miku Toyazaki
CPC分类号： C12P7/24 , C12N1/20 , C12N9/0006 , C12N9/0008 , C12N9/0069 , C12N9/0073 , C12N9/1007 , C12N9/1085 , C12N9/88 , C12P7/22 , C12P7/42 , C12Y101/01001 , C12Y101/01025 , C12Y102/99007 , C12Y113/11003 , C12Y114/13082 , C12Y201/01015 , C12Y205/01054 , C12Y402/0101 , C12Y402/01118 , C12Y402/03004
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of an L-cysteine biosynthesis enzyme is increased.
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6.发明申请公开(公告)号：US20190241914A1
公开(公告)日：2019-08-08
申请号：US16392776
申请日：2019-04-24
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Peter Kelly , Sayaka Asari , Miku Toyazaki , Keita Fukui
IPC分类号： C12P7/42
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of NCgl2048 protein is reduced.
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公开(公告)号：US20180334693A1
公开(公告)日：2018-11-22
申请号：US15982623
申请日：2018-05-17
申请人： AJINOMOTO CO., INC.
发明人： Christine Roche , Benjamin Mijts , Peter Kelly , Matthew Davis , Sayaka Asari , Keita Fukui , Miku Toyazaki
CPC分类号： C12P7/42 , C12N9/1003 , C12N9/78 , C12N9/88 , C12N15/77 , C12P7/22 , C12P7/24 , C12P13/12 , C12R1/15 , C12R1/19 , C12Y201/02003 , C12Y305/0401 , C12Y403/01017
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.
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公开(公告)号：US11680279B2
公开(公告)日：2023-06-20
申请号：US16200011
申请日：2018-11-26
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Rekha Murali , Sayaka Asari , Keita Fukui , Miku Toyazaki , Keiko Noguchi
IPC分类号： C12P13/12 , C12P7/24 , C12N9/10 , C12N9/06 , C12P7/42 , C12N1/20 , C12R1/15 , C12R1/19 , C12R1/46
CPC分类号： C12P7/24 , C12N1/205 , C12N9/0012 , C12N9/1014 , C12N9/1085 , C12P7/42 , C12P13/12 , C12R2001/15 , C12R2001/19 , C12R2001/46 , C12Y105/0102 , C12Y201/02002 , C12Y205/01006
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.
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公开(公告)号：US11053519B2
公开(公告)日：2021-07-06
申请号：US16392805
申请日：2019-04-24
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Peter Kelly , Sayaka Asari , Keita Fukui , Miku Toyazaki
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of S-adenosyl-L-homocysteine hydrolase is increased.
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公开(公告)号：US20190161776A1
公开(公告)日：2019-05-30
申请号：US16200011
申请日：2018-11-26
申请人： AJINOMOTO CO., INC.
发明人： Benjamin Mijts , Christine Roche , Rekha Murali , Sayaka Asari , Keita Fukui , Miku Toyazaki , Keiko Noguchi
摘要： A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.
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