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    METHOD FOR PRODUCING MONATIN USING AN L-AMINO ACID AMINOTRANSFERASE
    1.
    发明申请
    METHOD FOR PRODUCING MONATIN USING AN L-AMINO ACID AMINOTRANSFERASE 审中-公开
    使用L-氨基酸氨基转移酶生产维生素的方法

    公开(公告)号：US20140234916A1

    公开(公告)日：2014-08-21

    申请号：US14230766

    申请日：2014-03-31

    Applicant: Ajinomoto Co., Inc.

    Inventor： Yasuaki Takakura ,  Hiroomi Ogino ,  Masakazu Sugiyama ,  Kenichi Mori ,  Eri Tabuchi ,  Koki Ishikawa ,  Uno Tagami ,  Hidemi Fujii

    IPC: C12P13/04

    CPC classification number: C12P13/04 ,  C12N9/1096 ,  C12P17/10

    Abstract: The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the like. These production methods may further comprise condensing indole-3-pyruvate and pyruvate to form the 4R-IHOG, and deaminating a tryptophan to form the indole-3-pyruvate.

    Abstract translation: 本发明提供了提高2R，4R-莫纳甜产率的方法。 具体地说，本发明提供了制备2S，4R-莫纳甜或其盐的方法，包括在L-氨基酸的存在下将4R-1HOG与L-氨基酸氨基转移酶接触以形成2S，4R-莫纳甜; 一种制备2R，4R-莫纳甜或其盐的方法，包括使2S，4R-莫纳甜异构化形成2R，4R-莫纳甜; 等等。 这些制备方法还可以包括将吲哚-3-丙酮酸和丙酮酸缩合形成4R-1HOG，并使色氨酸脱氨基形成吲哚-3-丙酮酸盐。

    METHOD FOR PRODUCING PEPTIDE HYDRAZIDE, PEPTIDE AMIDE, AND PEPTIDE THIOESTER
    4.
    发明申请
    METHOD FOR PRODUCING PEPTIDE HYDRAZIDE, PEPTIDE AMIDE, AND PEPTIDE THIOESTER 审中-公开
    生产肽水解酶，肽类药物和肽类药物的方法

    公开(公告)号：US20160264626A1

    公开(公告)日：2016-09-15

    申请号：US15146589

    申请日：2016-05-04

    Applicant: AJINOMOTO CO., INC.

    Inventor： Akira OTAKA ,  Akira Shigenaga ,  Masakazu Sugiyama ,  Hidemi Fujii

    IPC: C07K7/06 ,  C07D249/00

    CPC classification number: C07K7/06 ,  C07D249/00 ,  C07K1/003 ,  C07K1/107 ,  C07K1/13

    Abstract: An object of the present invention is to provide a method for producing a peptide thioester compound, a peptide hydrazide compound, and a peptide amide compound. The present invention provides a method for producing a peptide hydrazide compound or a peptide amide compound by using a compound represented by Formula (2): wherein R1, R2, R3, and X are as defined in the specification, and using a hydrazine compound or an ammonia compound as a reaction reagent. The present invention also provides a method for producing a peptide thioester compound from the peptide hydrazide compound.

    Abstract translation: 其中R1，R2，R3和X如说明书中所定义，并且使用肼化合物或氨化合物作为反应试剂。 本发明还提供了从肽酰肼化合物制备肽硫酯化合物的方法。

    METHOD FOR PRODUCING CRYSTALS OF MUTIVALENT METAL SALT OF (2R, 4R) MONATIN
    6.
    发明申请
    METHOD FOR PRODUCING CRYSTALS OF MUTIVALENT METAL SALT OF (2R, 4R) MONATIN 审中-公开
    生产（2R，4R）维生素的金属盐的晶体的方法

    公开(公告)号：US20130164792A1

    公开(公告)日：2013-06-27

    申请号：US13678909

    申请日：2012-11-16

    Applicant: Ajinomoto Co., Inc.

    Inventor： Kenichi MORI ,  Masakazu Sugiyama ,  Mika Moriya ,  Shunichi Suzuki ,  Hidemi Fujii ,  Kyohei Fujiwara

    IPC: C07D209/20 ,  C12P17/10

    CPC classification number: C07D209/20 ,  C12P17/10 ,  C12Y206/01 ,  C12Y501/01

    Abstract: The present invention provides a method of efficiently producing a crystal of a (2R,4R)Monatin multivalent metal salt that has a good sweetness property and is excellent in storage stability. Specifically, the present invention provides the method of producing the crystal of the (2R,4R)Monatin multivalent metal salt comprising allowing an aldehyde or one or two or more enzymes capable of forming (2R,4R)Monatin from (2S,4R)Monatin to be acted on an aqueous solution containing the (2S,4R)Monatin in the presence of a multivalent metal ion to obtain the crystal of the (2R,4R)Monatin multivalent metal salt. The aldehyde may preferably be an aromatic aldehyde. The one or two or more enzyme may preferably be a racemase or one or more aminotransferases. The multivalent metal may preferably be a bivalent alkaline earth metal.

    Abstract translation: 本发明提供一种有效地制备具有良好的甜味性并且保存稳定性优异的（2R，4R）莫纳甜多金属盐晶体的方法。 具体地说，本发明提供了制备（2R，4R）莫纳甜多价金属盐晶体的方法，包括使（2，4R）莫纳甜能形成（2R，4R）莫纳甜的醛或一种或两种以上的酶 在含有（2S，4R）莫纳甜的水溶液中，在多价金属离子的存在下作用，得到（2R，4R）莫纳甜多晶金属盐的结晶。 醛可优选为芳族醛。 一种或两种或更多种酶可优选为消旋酶或一种或多种氨基转移酶。 多价金属可优选为二价碱土金属。

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