公开(公告)号：US10053491B2

公开(公告)日：2018-08-21

申请号：US15146589

申请日：2016-05-04

Applicant: AJINOMOTO CO., INC.

Inventor： Akira Otaka ,  Akira Shigenaga ,  Masakazu Sugiyama ,  Hidemi Fujii

IPC: C07K1/107 ,  C07K7/06 ,  C07K1/13 ,  C07K1/00 ,  C07D249/00

CPC classification number: C07K7/06 ,  C07D249/00 ,  C07K1/003 ,  C07K1/107 ,  C07K1/13

Abstract: An object of the present invention is to provide a method for producing a peptide thioester compound, a peptide hydrazide compound, and a peptide amide compound. The present invention provides a method for producing a peptide hydrazide compound or a peptide amide compound by using a compound represented by Formula (2): wherein R1, R2, R3, and X are as defined in the specification, and using a hydrazine compound or an ammonia compound as a reaction reagent. The present invention also provides a method for producing a peptide thioester compound from the peptide hydrazide compound.