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公开(公告)号：US20180305456A1
公开(公告)日：2018-10-25
申请号：US15680187
申请日：2017-08-17
申请人： Mark White , Sandeep Kumar , Christopher Chan , Spencer Liang , Lance Stapleton , Andrew W. Drake , Yosi Gozlan , Ilan Vaknin , Shirley Sameah-Greenwald , Liat Dassa , Zohar Tiran , Gad S. Cojocaru , Maya Kotturi , Hsin-Yuan Cheng , Kyle Hansen , David Nisim Giladi , Einav Safyon , Eran Ophir , Leonard Presta , Richard Theolis , Radhika Desai , Patrick Wall
发明人： Mark White , Sandeep Kumar , Christopher Chan , Spencer Liang , Lance Stapleton , Andrew W. Drake , Yosi Gozlan , Ilan Vaknin , Shirley Sameah-Greenwald , Liat Dassa , Zohar Tiran , Gad S. Cojocaru , Maya Kotturi , Hsin-Yuan Cheng , Kyle Hansen , David Nisim Giladi , Einav Safyon , Eran Ophir , Leonard Presta , Richard Theolis , Radhika Desai , Patrick Wall
摘要： Anti-PVRIG and anti-TIGIT antibodies are provided.
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公开(公告)号：US20140065111A1
公开(公告)日：2014-03-06
申请号：US13958277
申请日：2013-08-02
申请人： Lea Eisenbach , Yosi Gozlan , Esther Tzehoval
发明人： Lea Eisenbach , Yosi Gozlan , Esther Tzehoval
IPC分类号： C07K14/705 , A61K35/14
CPC分类号： C07K14/70503 , A61K35/17 , C07K14/7051 , C12N15/102
摘要： The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.
摘要翻译： 本发明涉及通过使TCR基因体细胞超突变增加T细胞受体（TCR）与其配体的亲和力的方法和系统。 本发明还涉及使用亲和力成熟TCR产生对所选抗原具有反应性的T细胞。
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公开(公告)号：US20190315834A1
公开(公告)日：2019-10-17
申请号：US16475683
申请日：2018-01-04
IPC分类号： C07K14/705 , A61P35/00
摘要： SIRPalpha-CD70 fusion proteins are provided. Accordingly, there is provided a SIRPalpha-CD70 fusion protein comprising a single amino acid linker between the SIRPalpha and the CD70. Also there is provided a SIRPalpha-CD70 fusion protein in a form of at least a homo-trimer. Also provided are polynucleotides and nucleic acid constructs encoding the SIRPalpha-CD70 fusion protein, host-cells expressing the SIRPalpha-CD70 fusion protein and methods of use thereof.
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公开(公告)号：US20180169238A1
公开(公告)日：2018-06-21
申请号：US15795135
申请日：2017-10-26
申请人： Mark White , Sandeep Kumar , Christopher Chan , Spencer Liang , Lance Stapleton , Andrew W. Drake , Yosi Gozlan , Ilan Vaknin , Shirley Sameah-Greenwald , Liat Dassa , Zohar Tiran , Gad S. Cojocaru , Maya Kotturi , Hsin-Yuan Cheng , Kyle Hansen , David Nisim Giladi , Einav Safyon , Eran Ophir , Leonard Presta , Richard Theolis , Radhika Desai , Patrick Wall
发明人： Mark White , Sandeep Kumar , Christopher Chan , Spencer Liang , Lance Stapleton , Andrew W. Drake , Yosi Gozlan , Ilan Vaknin , Shirley Sameah-Greenwald , Liat Dassa , Zohar Tiran , Gad S. Cojocaru , Maya Kotturi , Hsin-Yuan Cheng , Kyle Hansen , David Nisim Giladi , Einav Safyon , Eran Ophir , Leonard Presta , Richard Theolis , Radhika Desai , Patrick Wall
IPC分类号： A61K39/395
CPC分类号： C07K16/2809 , A61K39/39541 , A61K39/39558 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61P35/00 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/035 , C07K2319/33
摘要： Anti-PVRIG and anti-TIGIT antibodies are provided.
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